Barry I Joffe
University of the Witwatersrand
Internal medicineEndocrinologySurgeryCardiologyImmunologyArthritisType 2 diabetesInsulin resistanceRheumatoid arthritisBasal (medicine)CholesterolGlucagonTriglycerideDiseaseInsulinBody mass indexPathogenesisRisk factorObesityDiabetes mellitusHormoneMedicineBiologyGastroenterology
Publications 165
Clinicians should be cognizant of the close relationship that exists between two of the most common endocrine disorders, primary hypothyroidism and diabetes mellitus. This applies to patients with both type 1 and type 2 diabetes mellitus (T1DM and T2DM respectively). However, the association is greater in T1DM, probably because of the shared autoimmune predisposition. In patients with T2DM, the relationship is somewhat weaker and the explanation less clear-cut. Factors such as dietary iodine def...
12 CitationsSource
#1Patrick H Dessein (University of the Witwatersrand)H-Index: 24
#2Gavin R. Norton (University of the Witwatersrand)H-Index: 31
Last. Ahmed Solomon (University of the Witwatersrand)H-Index: 14
view all 7 authors...
Background The metabolic syndrome (MetS) and its components are associated with atherosclerosis in patients with rheumatoid arthritis (RA) that belong to developed populations [1-2]. Whereas approximately 80% of ACVD now occurs in developing countries [3], the impact of metabolic risk factors on atherosclerotic cardiovascular disease (ACVD) in patients with RA from developing populations is currently unknown. Objectives To compare the metabolic cardiovascular risk burden and the relationships of...
#1W. John Kalk (University of the Witwatersrand)H-Index: 8
#2Barry I JoffeH-Index: 34
Last. Anne E. SumnerH-Index: 33
view all 3 authors...
Abstract Background: Central obesity measured by waist circumference is a cardiovascular disease (CVD) risk factor; however, the waist circumference of risk in populations of African descent has not been identified. The International Diabetes Federation currently suggests that cutoffs established in men of European descent be applied to sub-Saharan men—a waist circumference ≥94 cm. Subjects and Methods: Participants were 203 South African black men with type 2 diabetes mellitus (T2DM). They were...
20 CitationsSource
#1Barry I JoffeH-Index: 34
#2Larry A. DistillerH-Index: 11
Last. Anna KlisiewiczH-Index: 1
view all 5 authors...
Most cases of Type 1 diabetes mellitus (T1DM) are thought to result from selective autoimmune destruction of pancreatic beta cells. In keeping with the autoimmune aetiology, other autoimmune diseases occur with increased frequency. The purpose of this study was to determine the frequency of hypothyroidism, adrenocortical insufficiency, pernicious anaemia, coeliac disease, vitiligo and systemic autoimmune disorders in 504 patients with longstanding T1DM. The prevalence of documented hypothyroidis...
14 CitationsSource
#1W.J. Kalk (University of the Witwatersrand)H-Index: 1
#1W. J. Kalk (University of the Witwatersrand)H-Index: 3
Last. Barry I Joffe (University of the Witwatersrand)H-Index: 34
view all 3 authors...
Abstract Background Type 1 diabetes (T1DM) in sub-Saharan Africans is rare and is associated with high mortality from nephropathy. We studied the prevalence and potential risk factors for microalbuminuria (MA) in African and in age-of-onset matched white patients with T1DM. Risk factors for MA were evaluated prospectively in an African cohort. Materials and Methods 68 African and 134 white patients, age at diagnosis 10–40 years, duration of diabetes > 2 years, were evaluated for MA; 48 Africans ...
8 CitationsSource
#1L. A. DistillerH-Index: 1
#2M. A. BrownH-Index: 1
Last. B. D. KramerH-Index: 1
view all 4 authors...
Diabet. Med. 27, 197–202 (2010) Abstract Aims In 1994 the Centre for Diabetes and Endocrinology (CDE) based in Johannesburg, South Africa established a novel community-based capitation and risk-sharing model for diabetes management. We here describe the model and present a recent survey of the performance/outcomes of this unique diabetes care programme. Methods Data on 17 043 patients managed by the CDE Diabetes Management Programme at its Centre and its 262 affiliated Centres were analysed from...
28 CitationsSource
Having read the article by Goedecke et al. (1) with interest, a number of discrepancies inherent in their conclusions deserve comment. Many of the initial studies reporting reduced insulin secretion in black South Africans were performed several decades ago (2). Since then, considerable lifestyle changes have occurred in this segment of the …
2 CitationsSource
#1Patrick H DesseinH-Index: 18
Last. Ahmed SolomonH-Index: 5
view all 6 authors...
The metabolic syndrome is a cluster of cardiovascular risk factors that are of metabolic origin and include atherogenic dyslipidemia, hypertension and hyperglycemia. This syndrome is generally considered to develop as a consequence of excess adiposity- mediated insulin resistance. In rheumatoid arthritis (RA), apart from excess adiposity, high-grade inflammation, routine glucocorticoid use and subclinical hypothyroidism are further implicated in insulin resistance. Several more recently uncovere...
1 CitationsSource
#1Vanessa R. Panz (University of the Witwatersrand)H-Index: 15
#2Mary-Anne Kedda (University of the Witwatersrand)H-Index: 6
Last. Barry I Joffe (University of the Witwatersrand)H-Index: 34
view all 3 authors...
#1Barry I JoffeH-Index: 34
#2Irving M. SpitzH-Index: 51
Last. Seftel HcH-Index: 17
view all 6 authors...
: The present investigation defined the pattern of pancreatic, pituitary and adrenal responses after insulin-induced hypoglycemia in chronic calcific pancreatitis (CCP) related to alcohol abuse, and assessed the role of some of these hormones in the counterregulation of blood glucose. We studied 6 Black men with recently diagnosed CCP, all showing radiological evidence of pancreatic calcification and normal glucose tolerance, as well as 7 matched nonobese male controls. After a standard iv insul...
1 CitationsSource