Alfredo Mirandola
IrradiationOpticsRadiologyIonIonization chamberBeam (structure)Atomic physicsMaterials scienceMedical physicsPencil-beam scanningParticle therapyProton therapyBragg peakCarbon Ion RadiotherapyNuclear medicineRadiation therapyProtonMedicineDosimetryDetector
88Publications
15H-index
625Citations
Publications 86
Newest
#1E. MastellaH-Index: 7
#2Alfredo MirandolaH-Index: 15
Last. Mario CioccaH-Index: 27
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Abstract Purpose The robustness against setup and motion uncertainties of gated four-dimensional restricted robust optimization (4DRRO) was investigated for hypofractionated carbon ion radiotherapy (CIRT) of lung tumors. Methods CIRT plans of 9 patients were optimized using 4DRRO strategy with 3 mm setup errors, 3% density errors and 3 breathing phases related to the gate window. The prescription was 60 Gy(RBE) in 4 fractions. Standard spots (SS) were compared to big spots (BS). Plans were recal...
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#1Amelia BarcelliniH-Index: 3
#2Antonino DittoH-Index: 29
Last. Ester OrlandiH-Index: 23
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Background:The management of primary or recurrent vaginal tumours in an aging population is challenging for gynecologic and radiation oncologists. In patients unsuited for surgery and already irrad...
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#1Amelia BarcelliniH-Index: 3
#2Marianna Roccio (UNIPV: University of Pavia)H-Index: 9
Last. Angiolo Gadducci (UniPi: University of Pisa)H-Index: 57
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Background and Summary: The management of endometrial cancer, in an ever-older population with considerable comorbidity, remains a challenge for gynecological and radiation oncologists. Key Message: The present paper reviews literature data on treatment options for endometrial cancer patients unfit for surgery.
2 CitationsSource
#1Veronica Dusi (UNIPV: University of Pavia)H-Index: 6
#2Viviana VitoloH-Index: 11
Last. Roberto RordorfH-Index: 12
view all 16 authors...
1 CitationsSource
#1Barbara VischioniH-Index: 14
#2Alfredo MirandolaH-Index: 15
Last. Francesca ValvoH-Index: 15
view all 15 authors...
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#1Alberto IannalfiH-Index: 11
#2E. D’IppolitoH-Index: 4
Last. Roberto Orecchia (IEO: European Institute of Oncology)H-Index: 71
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BACKGROUND: The aim of this study is to evaluate results in terms of local control (LC), overall survival (OS) and toxicity profile and to better identify factors influencing clinical outcome of skull base chordoma treated with proton therapy (PT) and carbon ion therapy (CIRT). METHODS: We prospectively collected and analyzed data of 135 patients treated between 11/2011 and 12/2018. Total prescription dose in PT group (70 patients) and CIRT group (65 patients) was 74 Gy(RBE) delivered in 37 frac...
6 CitationsSource
#1Amelia BarcelliniH-Index: 4
#2Viviana VitoloH-Index: 11
Last. Francesca ValvoH-Index: 15
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BACKGROUND/AIM: Re-irradiation of locally recurrent rectal cancer poses challenges due to the proximity of critical organs, such as the bowel. This study aimed at evaluating the safety and efficacy of re-irradiation with Carbon Ion Radiotherapy (CIRT) in rectal cancer patients with local recurrence. PATIENTS AND METHODS: Between 2014 and 2018, 14 patients were treated at the National Center of Oncological Hadrontherapy (CNAO Foundation) with CIRT for locally recurrent rectal cancer. RESULTS: All...
3 CitationsSource
#1Barbara VischioniH-Index: 14
#2B. Dhanireddy (Albert B. Chandler Hospital)H-Index: 1
Last. Roberto Orecchia (IEO: European Institute of Oncology)H-Index: 71
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Abstract Aims To report oncologic and functional outcomes in terms of tumor control and toxicity of carbon ion radiotherapy (CIRT) in reirradiation setting for recurrent salivary gland tumors at CNAO. Methods From November 2013 to September 2016, 51 consecutive patients with inoperable recurrent salivary gland tumors were retreated with CIRT in the frame of the phase II protocol CNAO S14/2012C for recurrent head and neck tumors. Results Majority of pts (74.5%) had adenoid cystic carcinoma, mainl...
5 CitationsSource
#1Viviana VitoloH-Index: 11
#2Amelia BarcelliniH-Index: 4
Last. Francesca ValvoH-Index: 15
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In inoperable patients, the management of angiosarcoma of the scalp is challenging. Due to intrinsic, dosimetric and radiobiological properties, proton beam radiotherapy may be an effective and safe option to offer to these difficult-to-cure patients. Here, we report a case of angiosarcoma of the scalp treated successfully with proton beam radiotherapy. Angiosarcoma is a rare malignancy concerning around 2% of soft-tissue sarcomas and 5% of cutaneous soft-tissue sarcomas. Cutaneous angiosarcomas...
1 CitationsSource
#1Kyungdon ChoiH-Index: 5
#2Silvia MolinelliH-Index: 17
Last. Andrea MairaniH-Index: 22
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The clinical application of different relative biological effectiveness (RBE) models for carbon ion RBE-weighted dose calculation hinders a global consensus in defining normal tissue constraints. This work aims to update the local effect model (LEM)-based constraints for the rectum using microdosimetric kinetic model (mMKM)-defined values, relying on RBE translation and the analysis of long-term clinical outcomes. LEM-optimized plans of treated patients, having suffered from prostate adenocarcin...
2 CitationsSource