Jennifer E. Gains
University College Hospital
Quality assuranceInternal medicineRadiologySurgeryPathologyOncologyRandomized controlled trialIntensive care medicinePediatricsMedical physicsAdverse effectPositron emission tomographyExternal beam radiotherapyNeuroblastomaBrachytherapyCommon Terminology Criteria for Adverse EventsDiseaseRhabdomyosarcomaPaediatric oncologyMeta iodobenzylguanidineNuclear medicineRadionuclide therapyHigh risk neuroblastomaRefractoryRadiation therapyClinical trialMedicineDosimetrySomatostatin receptor
23Publications
9H-index
323Citations
Publications 20
Newest
#1P.S. Lim (UCL: University College London)H-Index: 1
#2V. Rompokos (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 2
Last. Jennifer E. Gains (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 9
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Abstract Aims Pencil beam scanning (PBS) proton therapy is an increasingly used radiation modality for childhood malignancies due to its ability to minimise dose to surrounding organs. However, the dosimetry is extremely sensitive to anatomical and density changes. The aims of this study were to investigate if there is a dosimetric benefit or detriment with PBS for paediatric abdominal neuroblastoma, assess gastrointestinal air variability and its dosimetric consequences, plus identify if there ...
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#1Myra Bluebond-Langner (UCL: University College London)H-Index: 21
#2Nicolas Hall (UCL: University College London)H-Index: 1
Last. Darren Hargrave (UCL: University College London)H-Index: 42
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Background Previous studies have found that parents of children with cancer desire more prognostic information than is often given even when prognosis is poor. We explored in audio-recorded consultations the kinds of information they seek. Methods Ethnographic study including observation and audio recording of consultations at diagnosis. Consultations were transcribed and analyzed using an interactionist perspective including tools drawn from conversation and discourse analysis. Results Enrolled...
2 CitationsSource
#1Matthew D. Aldridge (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 5
#2Connie Peet (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 1
Last. Mark N. Gaze (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 28
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The common contemporary indications for paediatric molecular radiotherapy (pMRT) are differentiated thyroid cancer and neuroblastoma. It may also have value in neuroendocrine cancers, and it is being investigated in clinical trials for other diseases. pMRT is the prototypical biomarker-driven, precision therapy, with a unique mode of delivery and mechanism of action. It is safe and well tolerated, compared with other treatments. However, its full potential has not yet been achieved, and its wide...
1 CitationsSource
#1Niruthiga Arunagiri (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 1
#2S. Kelly (European Organisation for Research and Treatment of Cancer)H-Index: 2
Last. Mark N. Gaze (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 28
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Abstract Background Radiation may cause long-term splenic dysfunction, risking potentially fatal late sepsis. We aimed to review this complication's magnitude in paediatric radiotherapy and gauge the level of awareness of the spleen as an organ at risk. Methods Clinical trial protocols and radiotherapy guidelines, patient/parent information sheets, and professional guidance documents were reviewed to assess the perceived risk of radiotherapy-related splenic dysfunction. Paediatric oncologists an...
2 CitationsSource
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#1Jennifer E. GainsH-Index: 9
#2Matthew D. Aldridge (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 5
Last. Mark N. GazeH-Index: 28
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PURPOSE Iodine-131-labelled meta-iodobenzylguanidine (I-mIBG) and lutetium-177-labelled DOTATATE (Lu-DOTATATE) are used for molecular radiotherapy of metastatic neuroblastoma. These are taken up by the noradrenaline transporter (NAT) and the somatostatin receptor subtype 2 (SSTR-2), respectively. Scintigraphy of iodine-123-labelled meta-iodobenzylguanidine (I-mIBG) and gallium-68 DOTATATE (Ga-DOTATATE) PET are used to select patients for therapy. These demonstrate the extent and location of tumo...
3 CitationsSource
#2Tom BoterbergH-Index: 31
Last. Henry MandevilleH-Index: 14
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#2April-Louise Smith (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 1
Last. Mark N. GazeH-Index: 28
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Molecular radiotherapy, or targeted radionuclide therapy, uses systemically administered drugs bearing a suitable radioactive isotope, typically a beta emitter. These are delivered via metabolic or other physiological pathways to cancer cells in greater concentrations than to normal tissues. The absorbed radiation dose in tumour deposits causes chromosomal damage and cell death. A partner radiopharmaceutical, most commonly the same vector labelled with a different radioactive atom, with emission...
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#1Jennifer E. Gains (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 9
#2Veronica Moroz (University of Birmingham)H-Index: 9
Last. Mark N. Gaze (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 28
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PURPOSE: The objective of this phase IIa, open-label, single-centre, single-arm, two-stage clinical trial was to evaluate the safety and activity of 177-lutetium DOTATATE (LuDO) molecular radiotherapy in neuroblastoma. METHODS: Children with relapsed or refractory metastatic high-risk neuroblastoma were treated with up to four courses of LuDO. The administered activity was 75 to 100 MBq kg(-1) per course, spaced at 8- to 12-week intervals. Outcomes were assessed by the International Neuroblastom...
6 CitationsSource
#1S Arumugam (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 1
#2NJ Manning-Cork (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 1
Last. Mark N. Gaze (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 28
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Abstract Aims External beam radiotherapy is widely used in various ways in the management of neuroblastoma. Despite extensive clinical experience, the precise role of radiotherapy in neuroblastoma remains unclear. The purpose of this systematic review was to survey the published literature to identify, without bias, the evidence for the clinical effectiveness of external beam radiotherapy as part of the initial multimodality treatment of high-risk neuroblastoma. We considered four areas: treatme...
8 CitationsSource