Jørgen Vestbo
University of Manchester
Internal medicineSurgeryCardiologyRandomized controlled trialIntensive care medicinePhysical therapyProspective cohort studyImmunologyAsthmaRespiratory diseaseCOPDExacerbationObstructive lung diseaseLungSpirometryPopulationPulmonary diseaseMedicineCohortGastroenterology
Publications 776
#1James P. Allinson (NIH: National Institutes of Health)H-Index: 10
#2Shoaib Afzal (Copenhagen University Hospital)H-Index: 31
Last. Guy Brusselle (Ghent University Hospital)H-Index: 88
view all 29 authors...
Background null During the past century, socioeconomic and scientific advances have resulted in changes in the health and physique of European populations. Accompanying improvements in lung function, if unrecognised, could result in the misclassification of lung function measurements and misdiagnosis of lung diseases. We therefore investigated changes in population lung function with birth year across the past century, accounting for increasing population height, and examined how such changes mi...
#1Alexander G. Mathioudakis (University of Manchester)H-Index: 15
#2Fekri AbrougH-Index: 40
Last. Guy Brusselle (EUR: Erasmus University Rotterdam)H-Index: 88
view all 49 authors...
Clinical trials evaluating the management of acute exacerbations of COPD assess heterogeneous outcomes, often omitting those that are clinically relevant or more important to patients. We have developed a core outcome set, a consensus-based minimum set of important outcomes that we recommend are evaluated in all future clinical trials on exacerbations management, to improve their quality and comparability. COPD exacerbations outcomes were identified through methodological systematic reviews and ...
#1Jacob Louis Marott (Frederiksberg Hospital)H-Index: 32
#2Truls Sylvan Ingebrigtsen (Copenhagen University Hospital)H-Index: 14
Last. Peter Lange (UCPH: University of Copenhagen)H-Index: 86
view all 5 authors...
Rationale: Natural history of Preserved Ratio Impaired Spirometry (PRISm), often defined as FEV1/FVC≥lower limit of normal and FEV1<80% of predicted value, is not well-described. Objective: To inve...
1 CitationsSource
#1Signe Vedel-Krogh (UCPH: University of Copenhagen)H-Index: 9
#2Sune F. Nielsen (Copenhagen University Hospital)H-Index: 34
Last. Jørgen Vestbo (MAHSC: Manchester Academic Health Science Centre)H-Index: 120
view all 5 authors...
Abstract null null Background null Asthma and COPD diagnoses are used to classify chronic airway diseases; however, both diseases are related to phenotypic traits like allergy, obesity, cough, sputum production, low-grade inflammation, smoking, elevated blood eosinophil count, comorbidities, and occupational exposures. Whether such traits can replace asthma and COPD diagnoses when assessing risk of exacerbation is unclear. null We tested the hypothesis that individuals with either asthma or COPD...
#1Gideon Katzenberg (University of Manchester)
#2Andrew Deacon (University of Manchester)
Last. Jørgen Vestbo (University of Manchester)H-Index: 120
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Chronic obstructive pulmonary disease is a prevalent condition in the UK, associated with high morbidity and mortality. Hospital physicians manage a significant portion of acute chronic obstructive pulmonary disease admissions to hospital and readmissions after discharge. Optimal management of exacerbations requires controlled oxygen therapy and ventilatory support where necessary, and careful administration of bronchodilators, steroids and antibiotics. Holistic care for these patients includes ...
#1Emily P. Brigham (Johns Hopkins University)H-Index: 13
#2Julie A. Anderson (GSK: GlaxoSmithKline)H-Index: 28
Last. Meredith C. McCormack (Johns Hopkins University)H-Index: 28
view all 15 authors...
Populations with COPD demonstrate higher survival in overweight and obese compared with normal weight; the “obesity paradox.” Relationships in less severe COPD are unclear, as is the impact of cardiovascular risk, and few studies include individuals at extremes of obesity. null We examined the relationship between body mass index (BMI, defined as underweight: null null Consistent with the paradox, underweight individuals demonstrated higher mortality (HR 1.31 (95%CI 1.04–1.64)), with lower morta...
1 CitationsSource
#1Fahad Alahmadi (Taibah University)H-Index: 1
#2Andrew J. Simpson (University of Hull)H-Index: 5
Last. Stephen J. Fowler (MAHSC: Manchester Academic Health Science Centre)H-Index: 35
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ABSTRACT Background Whilst estimates of sub-optimal adherence to oral corticosteroids in asthma range from 30 to 50%, no ideal method for measurement exists; the impact of poor adherence in severe asthma is likely to be particularly high. Research Questions 1. What is the prevalence of suboptimal adherence detected using self-reporting and direct measures? 2. Is suboptimal adherence associated with disease activity? Study Design and Methods Data were included from individuals with severe asthma ...
2 CitationsSource
#1Alexander G. Mathioudakis (MAHSC: Manchester Academic Health Science Centre)H-Index: 15
#2Sachin Ananth (University of Hertfordshire)H-Index: 1
Last. Jørgen Vestbo (MAHSC: Manchester Academic Health Science Centre)H-Index: 120
view all 3 authors...
#1Pradeesh Sivapalan (UCPH: University of Copenhagen)H-Index: 7
#2Andras Bikov (University of Manchester)H-Index: 17
Last. Jens-Ulrik Stæhr Jensen (UCPH: University of Copenhagen)H-Index: 20
view all 10 authors...
The CORTICO-COP trial showed that eosinophil-guided corticosteroid-sparing treatment for acute exacerbation of chronic obstructive pulmonary disease was non-inferior to standard of care and decreased the accumulated dose of systemic corticosteroids that patients were exposed to by approximately 60%. Smoking status has been shown to affect corticosteroid responsiveness. This post hoc analysis investigated whether eosinophil-guided treatment is non-inferior to conventional treatment in current smo...
#1Yunus Çolak (Copenhagen University Hospital)H-Index: 15
#2Børge G. Nordestgaard (Copenhagen University Hospital)H-Index: 158
Last. Shoaib Afzal (Copenhagen University Hospital)H-Index: 31
view all 5 authors...
Abstract null null Background null Investigation of the natural history of chronic obstructive pulmonary disease (COPD) has led to the recognition that individuals with higher than normal lung function may have lower risk of developing COPD. We tested the hypothesis that individuals with supernormal lung function have lower risk of COPD. null null null Methods null We followed 108,246 adults from the Copenhagen General Population Study recruited between 2003 and 2015 for clinical COPD outcomes u...