Heidi S. M. Ammerlaan
University Medical Center Utrecht
Drug resistanceInternal medicineSurgeryAntibodyRandomized controlled trialIntensive care medicineMortality rateProspective cohort studyEmergency medicineAdverse effectCohort studyImmunologyObservational studyComplete blood countHepatitis CMen who have sex with menMethicillin-resistant Staphylococcus aureusStaphylococcal infectionsSeptic shockMupirocinBacteremiaStaphylococcus aureusGuidelinePrognostic scoreHIV SeronegativityIntensive careCoronavirus disease 2019 (COVID-19)Clinical severityHospital based studyCell activationTiterCarriageIncidence (epidemiology)PharmacotherapyAntibioticsFamily medicineMedicine
20Publications
12H-index
728Citations
Publications 20
Newest
#1Valentijn A. Schweitzer (University Medical Center Utrecht)H-Index: 5
#2Inger van HeijlH-Index: 2
Last. Marc J. M. Bonten (University Medical Center Utrecht)H-Index: 99
view all 21 authors...
Summary null null Background null Adults hospitalised to a non-intensive care unit (ICU) ward with moderately severe community-acquired pneumonia are frequently treated with broad-spectrum antibiotics, despite Dutch guidelines recommending narrow-spectrum antibiotics. Therefore, we investigated whether an antibiotic stewardship intervention would reduce the use of broad-spectrum antibiotics in patients with moderately severe community-acquired pneumonia without compromising their safety. null nu...
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#1Arvind Gharbharan (EUR: Erasmus University Rotterdam)H-Index: 4
#2Carlijn C E Jordans (EUR: Erasmus University Rotterdam)H-Index: 2
Last. Adrianus KosterH-Index: 1
view all 32 authors...
In a randomized clinical trial of 86 hospitalized COVID-19 patients comparing standard care to treatment with 300mL convalescent plasma containing high titers of neutralizing SARS-CoV-2 antibodies, no overall clinical benefit was observed. Using a comprehensive translational approach, we unravel the virological and immunological responses following treatment to disentangle which COVID-19 patients may benefit and should be the focus of future studies. Convalescent plasma is safe, does not improve...
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#1J.W. Timotëus Deelen (University Medical Center Utrecht)H-Index: 1
#2Wouter C. RottierH-Index: 8
Last. C.H. van WerkhovenH-Index: 10
view all 12 authors...
Abstract Objective Short-course aminoglycosides as adjunctive empirical therapy to beta-lactams in patients with a clinical suspicion of sepsis is used to broaden antibiotic susceptibility coverage and to enhance bacterial killing. We quantified the impact of this approach on 30-day mortality in a subset of sepsis patients with a Gram-negative bloodstream infection. Methods From a prospective cohort study conducted in 7 hospitals in the Netherlands between June 2013 and November 2015, we selecte...
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#1Joachim LinssenH-Index: 2
#2Anthony ErmensH-Index: 1
Last. André J. A. M. van der Ven (Radboud University Nijmegen)H-Index: 46
view all 23 authors...
COVID-19 induces haemocytometric changes. Complete blood count changes, including new cell activation parameters, from 982 confirmed COVID-19 adult patients from 11 European hospitals were retrospectively analysed for distinctive patterns based on age, gender, clinical severity, symptom duration, and hospital days. The observed haemocytometric patterns formed the basis to develop a multi-haemocytometric-parameter prognostic score to predict, during the first three days after presentation, which ...
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#1Joachim LinssenH-Index: 2
#2Anthony ErmensH-Index: 1
Last. André J. A. M. van der Ven (Radboud University Nijmegen)H-Index: 46
view all 23 authors...
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#1Joachim LinssenH-Index: 2
#2Anthony ErmensH-Index: 1
Last. André J. A. M. van der Ven (Radboud University Nijmegen)H-Index: 46
view all 23 authors...
Abstract COVID-19 induces haemocytometric changes. Complete blood count changes, including new cell activation parameters, from 982 confirmed COVID-19 adult patients from 11 European hospitals were retrospectively analysed for distinctive patterns based on age, gender, clinical severity, symptom duration and hospital days. The observed haemocytometric patterns formed the basis to develop a multi-haemocytometric-parameter prognostic score to predict, during the first three days after presentation...
Source
#1Arvind Gharbharan (EUR: Erasmus University Rotterdam)H-Index: 4
#2Carlijn C E Jordans (EUR: Erasmus University Rotterdam)H-Index: 2
Last. Bart J. A. Rijnders (EUR: Erasmus University Rotterdam)H-Index: 39
view all 28 authors...
Background After recovery from COVID-19, most patients have anti-SARS-CoV-2 neutralizing antibodies. Their convalescent plasma could be an inexpensive and widely available treatment for COVID-19. Methods The Convalescent-plasma-for-COVID (ConCOVID) study was a randomized trial comparing convalescent plasma with standard of care therapy in patients hospitalized for COVID-19 in the Netherlands. Patients were randomized 1:1 and received 300ml of plasma with anti-SARS-CoV-2 neutralizing antibody tit...
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#1Anne Boerekamps (EUR: Erasmus University Rotterdam)H-Index: 6
#2Anja De Weggheleire (Institute of Tropical Medicine Antwerp)H-Index: 9
Last. Bart J. A. Rijnders (EUR: Erasmus University Rotterdam)H-Index: 39
view all 21 authors...
Summary Background Direct-acting antivirals effectively treat chronic hepatitis C virus (HCV) infection but there is a paucity of data on their efficacy for acute HCV, when immediate treatment could prevent onward transmission. We assessed the efficacy of grazoprevir plus elbasvir treatment in acute HCV infection and investigated whether treatment can be shortened during the acute phase of HCV infection. Methods The Dutch Acute HCV in HIV study number 2 (DAHHS2) study was a single-arm, open-labe...
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#1Anne Boerekamps (EUR: Erasmus University Rotterdam)H-Index: 6
#2Kristien WoutersH-Index: 7
Last. Bart J. A. RijndersH-Index: 39
view all 6 authors...
BACKGROUND: The evidence that HIV treatment as prevention (TasP) and HIV pre-exposure prophylaxis (PrEP) reduces the risk of HIV transmission is overwhelming. But as PrEP and TasP can lead to increased sexual mixing between HIV positive and negative men who have sex with men (MSM), sexually transmitted infections such as acute hepatitis C (HCV), which were thought to be limited to HIV-infected MSM, could become more frequent in HIV uninfected MSM as well. The objective of this study was to descr...
#1Anne Boerekamps (EUR: Erasmus University Rotterdam)H-Index: 6
#2Kristien WoutersH-Index: 7
Last. Bart J. A. Rijnders (EUR: Erasmus University Rotterdam)H-Index: 39
view all 6 authors...
The evidence that HIV treatment as prevention (TaSP) and HIV pre-exposure prophylaxis (PrEP) reduce the risk of HIV transmission is overwhelming. The logical consequence of both interventions is that sexual mixing between HIV-positive and negative men who have sex with men (MSM) will increase. Hepatitis C (HCV) can be sexually transmitted in MSM and until recently was thought to be limited to HIV-infected MSM. However, from January 2016 to July 2017, through the Dutch Acute HCV in HIV Study (a D...
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