Yoshihiko Kanno
Tokyo Medical University
Internal medicineUrologyEndocrinologySurgeryRenal functionCardiologyIntensive care medicineMaterials scienceHemodialysisKidney diseaseDiabetic nephropathyDialysisKidneyCreatinineNephropathyAngiotensin IIIn patientNephrologyMedicineBlood pressure
Publications 219
#1Takahiro Ito (Keio: Keio University)H-Index: 4
#2Takashi Ota (Keio: Keio University)H-Index: 1
Last. Norihisa Miki (Keio: Keio University)H-Index: 24
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Hemofiltration removes water and small molecules from the blood via nanoporous filtering membranes. This paper discusses a pump-free hemofiltration device driven by the pressure difference between the artery and the vein. In the design of the filtering device, oncotic pressure needs to be taken into consideration. Transmembrane pressure (TMP) determines the amount and direction of hemofiltration, which is calculated by subtracting the oncotic pressure from the blood pressure. Blood pressure decr...
#1Yasuhiko Ito (Aichi Medical University)H-Index: 28
#2Munekazu RyuzakiH-Index: 15
Last. Noritomo ItamiH-Index: 21
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Approximately 10 years have passed since the Peritoneal Dialysis Guidelines were formulated in 2009. Much evidence has been reported during the succeeding years, which were not taken into consideration in the previous guidelines, e.g., the next peritoneal dialysis PD trial of encapsulating peritoneal sclerosis (EPS) in Japan, the significance of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), the effects of icodextrin solution, new developments in perit...
#1Yoshihiko KannoH-Index: 34
#2Eiichiro KandaH-Index: 16
Last. Akihiko KatoH-Index: 29
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Patients receiving dialysis therapy often have frailty, protein energy wasting, and sarcopenia. However, medical staff in Japan, except for registered dietitians, do not receive training in nutritional management at school or on the job. Moreover, registered dietitians work separately from patients and medical staff even inside a hospital, and there are many medical institutions that do not have registered dietitians. In such institutions, medical staff are required to manage patients’ nutrition...
2 CitationsSource
#1Yoshitaka Miyaoka (TMU: Tokyo Medical University)H-Index: 3
#2Tomonari Okada (TMU: Tokyo Medical University)
Last. Yoshihiko Kanno (TMU: Tokyo Medical University)H-Index: 34
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Although central hemodynamics are known to be closely associated with microvascular damage, their association with lesions in the small renal arteries has not yet been fully clarified. We focused on arterioles in renal biopsy specimens and analyzed whether their structural changes were associated with noninvasive vascular function parameters, including central blood pressure (BP) and brachial-ankle pulse wave velocity (baPWV). Forty-four nondiabetic patients (18-50 years of age) with preserved r...
#1Yukio MaruyamaH-Index: 18
#2Keitaro YokoyamaH-Index: 2
Last. Tatsuo HosoyaH-Index: 2
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#1Ayumi YoshifujiH-Index: 7
Last. Munekazu RyuzakiH-Index: 15
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A 65-year-old man with valvular disorder presented to his physician because of widespread purpura in both lower extremities. Blood tests showed elevated serum creatinine levels and proteinase 3-anti-neutrophil cytoplasmic antibody (ANCA) with hematuria, suggesting ANCA-related rapidly progressive glomerulonephritis (RPGN). Although multiple blood cultures were negative, transthoracic echocardiography revealed warts in the valves, and a renal biopsy also showed findings of glomerular infiltration...
#1Yoshihiko Kanno (TMU: Tokyo Medical University)H-Index: 34
Hypertension is the most common complication of kidney disease, diabetes, and other cardiovascular diseases. In addition, it is a critical factor in the progression of these diseases, and hence, blood pressure management is highly recommended worldwide, in accordance with the major guidelines. However, there are two blind spots in the management system: one concerns patients with cancer, and the other concerns patients receiving renal replacement therapy. End-stage renal failure is the final sta...
2 CitationsSource
Last. Yoshihiko Kanno (TMU: Tokyo Medical University)H-Index: 34
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BACKGROUND AND OBJECTIVES Topiroxostat, a selective xanthine oxidoreductase inhibitor, is used for the management of hyperuricemic patients with or without gout in Japan. Accumulating evidence has demonstrated the efficacy of topiroxostat for the treatment of hyperuricemia with or without gout. However, the safety and efficacy of topiroxostat in the clinical setting remain unclear, and there is little large-scale clinical evidence. We conducted a post-marketing observational study over 54 weeks....
#1Shinya Morita (Keio: Keio University)H-Index: 14
#2Kazunobu Shinoda (Toho University)H-Index: 8
Last. Mototsugu Oya (Keio: Keio University)H-Index: 56
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Cyclosporine A (CsA) is an essential immunosuppressant in organ transplantation. However, its chronic nephrotoxicity is an obstacle to long allograft survival that has not been overcome. Nuclear factor-κB (NF-κB) is activated in the renal tissue in CsA nephropathy. In this study, we aimed to investigate the effect of the specific NF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), in a rat model of CsA nephrotoxicity. We administered CsA (15 mg/kg) daily for 28 days to Sprague-Dawley rats t...
1 CitationsSource