Vellareddy Anantharam
Iowa State University
DopaminergicMolecular biologyNeuroscienceChemistryApoptosisNeuroprotectionOxidative stressNeurodegenerationNeurotoxicityParkinson's diseaseMitochondrionDopaminergic CellProgrammed cell deathBiochemistryMedicineBiologyNeuroinflammationCell biologyProtein kinase APharmacology
137Publications
57H-index
9,094Citations
Publications 135
Newest
#1Minhong Huang (Iowa State University)H-Index: 1
#2Dan Lou (Johns Hopkins University)H-Index: 6
Last. Anumantha G. Kanthasamy (Iowa State University)H-Index: 65
view all 10 authors...
Mitochondrial dysfunction is a major pathophysiological contributor to the progression of Parkinson's disease (PD); however, whether it contributes to epigenetic dysregulation remains unknown. Here, we show that both chemically and genetically driven mitochondrial dysfunctions share a common mechanism of epigenetic dysregulation. Under both scenarios, lysine 27 acetylation of likely variant H3.3 (H3.3K27ac) increased in dopaminergic neuronal models of PD, thereby opening that region to active en...
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#1Shivani Ghaisas (Iowa State University)H-Index: 13
#2Dilshan S. Harischandra (Iowa State University)H-Index: 19
Last. Vellareddy Anantharam (Iowa State University)H-Index: 57
view all 0 authors...
Background: Chronic environmental exposure to manganese (Mn) can cause debilitating damage to the central nervous system. However, its potential toxic effects on the enteric nervous system (ENS) ha...
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#1Benjamin W. Schlichtmann (Iowa State University)H-Index: 3
#2Balaraman Kalyanaraman (MCW: Medical College of Wisconsin)H-Index: 112
Last. Balaji Narasimhan (Iowa State University)H-Index: 50
view all 8 authors...
Parkinson's disease (PD) is a devastating neurodegenerative disease affecting a large proportion of older adults. Exposure to pesticides like rotenone is a leading cause for PD. To reduce disease progression and prolong life expectancy, it is important to target disease mechanisms that contribute to dopaminergic neuronal atrophy, including mitochondrial dysfunction. Achieving targeted mitochondrial delivery is difficult for many therapeutics by themselves, necessitating higher therapeutic doses ...
1 CitationsSource
Oxidative stress, neuroinflammation and apoptosis are some of the key etiological factors responsible for dopamin(DA)ergic degeneration during Parkinson’s disease (PD), yet the downstream molecular mechanisms underlying neurodegeneration are largely unknown. Recently, a genome-wide association study (GWAS) revealed the FYN gene to be associated with PD, suggesting that Fyn kinase could be a pharmacological target for PD. In this study, we report that Fyn-mediated PKCδ tyrosine (Y311) phosphoryla...
1 CitationsSource
#1Monica R. Langley (Iowa State University)H-Index: 12
#2Shivani Ghaisas (Iowa State University)H-Index: 13
Last. Anumantha G. Kanthasamy (Iowa State University)H-Index: 65
view all 8 authors...
Abstract Mitochondrial dysfunction has been implicated as a key player in the pathogenesis of Parkinson's disease (PD). The MitoPark mouse, a transgenic mitochondrial impairment model developed by specific inactivation of TFAM in dopaminergic neurons, spontaneously exhibits progressive motor deficits and neurodegeneration, recapitulating several features of PD. Since nonmotor symptoms are now recognized as important features of the prodromal stage of PD, we comprehensively assessed the clinicall...
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#1Benjamin W. Schlichtmann (Iowa State University)H-Index: 3
#2Monica Hepker (Iowa State University)H-Index: 1
Last. Surya K. Mallapragada (Iowa State University)H-Index: 42
view all 8 authors...
Synucleinopathies are a subset of debilitating neurodegenerative disorders for which clinically approved therapeutic options to either halt or retard disease progression are currently unavailable. Multiple synergistic pathological mechanisms in combination with the characteristic misfolding of proteins are attributable to disease pathogenesis and progression. This complex interplay, as well as the difficult and multiscale nature of therapeutic delivery into the central nervous system, make findi...
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#1Manikandan Samidurai (Iowa State University)H-Index: 5
#2Bharathi N. Palanisamy (Iowa State University)H-Index: 5
Last. Anumantha G. Kanthasamy (Iowa State University)H-Index: 65
view all 11 authors...
A classical hallmark of Parkinson's disease (PD) pathogenesis is the accumulation of misfolded alpha-synuclein (αSyn) within Lewy bodies and Lewy neurites, although its role in microglial dysfunction and resultant dopaminergic (DAergic) neurotoxicity is still elusive. Previously, we identified that protein kinase C delta (PKCδ) is activated in post mortem PD brains and experimental Parkinsonism and that it participates in reactive microgliosis; however, the relationship between PKCδ activation, ...
1 CitationsSource
#1Sireesha Manne (Iowa State University)H-Index: 10
#2Naveen Kondru (Iowa State University)H-Index: 11
Last. Anumantha G. Kanthasamy (Iowa State University)H-Index: 65
view all 9 authors...
Background An unmet clinical need in Parkinson's disease (PD) is to identify biomarkers for diagnosis, preferably in peripherally accessible tissues such as skin. Immunohistochemical studies have detected pathological α-synuclein (αSyn) in skin biopsies from PD patients albeit sensitivity needs to be improved. Objective Our study provides the ultrasensitive detection of pathological αSyn present in the skin of PD patients, and thus, pathological αSyn in skin could be a potential biomarker for PD...
20 CitationsSource
#1Benjamin W. Schlichtmann (Iowa State University)H-Index: 3
#2Naveen Kondru (Iowa State University)H-Index: 11
Last. Balaji Narasimhan (Iowa State University)H-Index: 50
view all 9 authors...
An assay for accurately diagnosing early stage Parkinson's Disease (PD) is currently unavailable, and therefore, there is an urgent and unmet need. Such a diagnostic assay will enable prompt institution of appropriate supportive management measures to prevent rapid deterioration of disease and improve both quality of life and life expectancy of PD patients. A reliable assay platform will also be of great benefit to drug discovery and drug development in the area of PD. To this end, we describe t...
1 CitationsSource
#1Manikandan Samidurai (Iowa State University)H-Index: 5
#2Prashant Tarale (Iowa State University)
Last. Arthi Kanthasamy (Iowa State University)H-Index: 54
view all 10 authors...
Astrocytic dysfunction has been implicated in Parkinson’s disease (PD) pathogenesis. While the Tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/Fn14 signaling axis is known to play a role in PD-like neuropathology, the molecular mechanisms that govern this process remain poorly understood. Herein, we show that TWEAK levels are elevated in PD serum compared to controls. Moreover, using both U373 human astrocyte cells and primary mouse astrocytes, we demonstrate that TWEAK induces mito...
1 CitationsSource