Matthew Borzage
University of Southern California
Internal medicinePathologyMagnetic resonance imagingCellDiffusion MRIPsychologyCerebral blood flowBlood flowCardiologyNeuroscienceCerebral arteriesHemodynamicsComplete blood countHeart rateGrey matterHemoglobin electrophoresisHydrocephalusAnemiaSickle cell anemiaHemoglobinDiseaseHematocritWhite matterDeoxygenated HemoglobinNuclear medicineAnesthesiaStrokeBrain sizeOxygenationMedicineStroke volume
Publications 44
#1Matthew BorzageH-Index: 10
Last. Kevin S. King (Barrow Neurological Institute)H-Index: 17
view all 6 authors...
BACKGROUND AND PURPOSE: null Many patients with dementia may have comorbid or misdiagnosed normal pressure hydrocephalus, a treatable neurologic disorder. The callosal angle is a validated biomarker for normal pressure hydrocephalus with 93% diagnostic accuracy. Our purpose was to develop and evaluate an algorithm for automatically computing callosal angles from MR images of the brain. null MATERIALS AND METHODS: null This article reports the results of analyzing callosal angles from 1856 subjec...
#1Stephanie Sincomb (UCSD: University of California, San Diego)H-Index: 1
#2Wilfried Coenen (Charles III University of Madrid)H-Index: 11
Last. Juan C. Lasheras (UCSD: University of California, San Diego)H-Index: 40
view all 9 authors...
BACKGROUND AND PURPOSE: null Measuring transmantle pressure, the instantaneous pressure difference between the lateral ventricles and the cranial subarachnoid space, by intracranial pressure sensors has limitations. The aim of this study was to compute transmantle pressure noninvasively with a novel nondimensional fluid mechanics model in volunteers and to identify differences related to age and aqueductal dimensions. null MATERIALS AND METHODS: null Brain MR images including cardiac-gated 2D ph...
#1Richard A.I. Bethlehem (University of Cambridge)H-Index: 16
#2Jakob Seidlitz (UPenn: University of Pennsylvania)H-Index: 20
Last. Areces-Gonzalez A (University of Electronic Science and Technology of China)H-Index: 1
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Over the past 25 years, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, there are no reference standards against which to anchor measures of individual differences in brain morphology, in contrast to growth charts for traits such as height and weight. Here, we built an interactive online resource ( to quantify individual differences in brain structure from any current or future magnetic resonance imaging (MRI) study,...
#1Chau Vu (SC: University of Southern California)H-Index: 4
#2Adam Bush (SC: University of Southern California)H-Index: 12
Last. John C. Wood (SC: University of Southern California)H-Index: 64
view all 8 authors...
Anemia is the most common blood disorder in the world. In patients with chronic anemia, such as sickle cell disease or major thalassemia, cerebral blood flow increases to compensate for decreased oxygen content. However, the effects of chronic anemia on oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2 ) are less well understood. In this study, we examined 47 sickle-cell anemia subjects (age 21.7±7.1, female 45%), 27 non-sickle anemic subjects (age 25.0±10.4, female 5...
#1Nhu N. Tran (SC: University of Southern California)H-Index: 1
#2Jodie K. Votava-Smith (SC: University of Southern California)H-Index: 13
Last. Bradley S. Peterson (SC: University of Southern California)H-Index: 99
view all 12 authors...
Objective Infants with Congenital Heart Disease (CHD) are at risk for developmental delays, though the mechanisms of brain injury that impair development are unknown. Potential causes could include cerebral hypoxia and cerebrovascular instability. We hypothesized that we would detect significantly reduced cerebral oxygen saturation and greater cerebrovascular instability in CHD infants compared to the healthy controls. Methods We performed a secondary analysis on a sample of 43 term infants (28 ...
#1Silvie Suriany (Children's Hospital Los Angeles)H-Index: 3
#2Iris Xu (Children's Hospital Los Angeles)
Last. Jon A Detterich (SC: University of Southern California)H-Index: 16
view all 12 authors...
Abstract Sickle cell anemia (SCA) is characterized by decreased red blood cell (RBC) deformability due to polymerization of deoxygenated hemoglobin, leading to abnormal mechanical properties of RBC, increased cellular adhesion, and microcirculatory obstruction. Prior work has demonstrated that NO• influences RBC hydration and deformability and is produced at a basal rate that increases under shear stress in normal RBC. Nevertheless, the origin and physiological relevance of nitric oxide (NO•) pr...
#1Adam Bush (SC: University of Southern California)H-Index: 12
#2Chau Vu (SC: University of Southern California)H-Index: 4
Last. John C. Wood (SC: University of Southern California)H-Index: 64
view all 10 authors...
PURPOSE Cerebral T2 oximetry is a non-invasive imaging method to measure blood T2 and cerebral venous oxygenation. Measured T2 values are converted to oximetry estimates using carefully validated and potentially disease-specific calibrations. In sickle cell disease, red blood cells have abnormal cell shape and membrane properties that alter T2 oximetry calibration relationships in clinically meaningful ways. Previous in vitro works by two independent groups established potentially competing cali...
#1Alexander Saunders (SC: University of Southern California)
#2Kevin S. King (Huntington Medical Research Institutes)H-Index: 17
Last. Matthew Borzage (SC: University of Southern California)H-Index: 10
view all 5 authors...
Purpose: To evaluate six cerebral arterial segmentation algorithms in a set of patients with a wide range of hemodynamic characteristics to determine real-world performance. Approach: Time-of-flight magnetic resonance angiograms were acquired from 33 subjects: normal controls (N = 11), sickle cell disease (N = 11), and non-sickle anemia (N = 11) using a 3 Tesla Philips Achieva scanner. Six segmentation algorithms were tested: (1) Otsu’s method, (2) K-means, (3) region growing, (4) active contour...
#1Ke Wei (Huntington Medical Research Institutes)H-Index: 2
#2Thao Tran (Huntington Medical Research Institutes)H-Index: 14
Last. Kevin S. King (Huntington Medical Research Institutes)H-Index: 17
view all 10 authors...
BACKGROUND AND PURPOSE Cirrhosis is associated with diffuse brain manganese deposition, which results in increased signal intensity (SI) in the brain on T1-weighted images, most often visualized in the globus pallidus. The purpose of this study was to determine if automated image intensity measurements can detect SI differences in the basal ganglia and other regions reported to have manganese deposition in patients with cirrhosis compared with controls. METHODS T1 FSPGR images were acquired on 2...
#1Chau Vu (SC: University of Southern California)H-Index: 4
#2Yaqiong Chai (SC: University of Southern California)H-Index: 5
Last. John C. Wood (SC: University of Southern California)H-Index: 64
view all 7 authors...
Purpose: Gadolinium-based dynamic susceptibility contrast (DSC) is commonly used to characterize blood flow in patients with stroke and brain tumors. Unfortunately, gadolinium contrast administration has been associated with adverse reactions and long-term accumulation in tissues. In this work, we propose an alternative deoxygenation-based DSC (dDSC) method that uses a transient hypoxia gas paradigm to deliver a bolus of paramagnetic deoxygenated hemoglobin to the cerebral vasculature for perfus...
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