Seiichi Kakegawa
Gunma University
GeneCancerInternal medicineRadiologySurgeryPathologyOncologyMolecular biologyCardiothoracic surgeryLung cancerCarcinomaPneumonectomyLungEpidermal growth factor receptorOncogeneAdenocarcinomaKRASMutationCancer researchMedicineBiology
60Publications
15H-index
756Citations
Publications 60
Newest
An 84-year-old man was referred to our out-patient clinic with an elongated mass localized to the retrosternal area that was incidentally identified by computed tomography. On 18F-fluorodeoxyglucose-positron emission tomography, this lesion showed intense tracer uptake. Thus, a surgical biopsy under thoracoscopy was performed. Histological examination revealed dense fibrous tissue associated with inflammatory cell infiltration. The immunoglobulin (Ig) G4/IgG plasma cell ratio was over 90%. Serum...
#1Yasuhiko OhtaH-Index: 21
#2Seiichi KakegawaH-Index: 15
Last. Atsuhiro KawashimaH-Index: 28
view all 5 authors...
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A 65-year-old woman presented with mycosis fungoides and an anterior mediastinal tumor. Stage Ⅱa mycosis fungoides was treated with bath psoralen plus ultraviolet A, topical corticosteroids, and oral bexarotene. One month later, a surgical resection was performed for the anterior mediastinal tumor, which was a stage Ⅱ thymoma with membrane invasion. Furthermore, adjuvant radiotherapy was performed for anterior mediastinum. The mycosis fungoides lesion exacerbated after 3 months;thus, chemotherap...
#1Yusuke Tanaka (Kanazawa University)H-Index: 3
#2Isao MatsumotoH-Index: 19
Last. Hirofumi TakemuraH-Index: 16
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It is often difficult to control perioperative bleeding in patients with liver cirrhosis and concurrent thrombocytopenia and coagulation factor deficiency. Partial splenic embolization (PSE), an auxiliary treatment strategy in management of liver cirrhosis and hepatocellular carcinoma, can not only increase platelets but also improve liver function. With advances in interventional radiology, PSE is a safer and more reliable procedure compared to a splenectomy. We present the case of a 69-year-ol...
#1Yusuke Tanaka (Kanazawa University)H-Index: 3
#2Isao MatsumotoH-Index: 19
Last. Hiroko IkedaH-Index: 43
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We reported a case of bronchial atresia requiring differentiation from the intralobar sequestration. A 42-year-old man was referred to our institution with suspicion of intralobar sequestration, based on a 3-dimensional computed tomography (CT) angiography that showed abnormal blood vessels from the right inferior phrenic artery flowing into the right lower lobe. CT revealed a lesion between S9 and S10 wherein there were refluxed blood vessels from A9 without an accompanying bronchus, with polyc...
#1Tomoya KawaguchiH-Index: 28
#2Yasuhiro KohH-Index: 26
Last. Akihide MatsumuraH-Index: 29
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PurposeOncogenic driver mutations are critical for lung cancer development and serve as therapeutic targets. However, their associations with environmental factors are not fully understood. We aimed to elucidate the relationship between tumor developmental biology and exposure to environmental factors.Patients and MethodsThis was a prospective, multicenter, molecular epidemiology study. Eligible patients were those with newly diagnosed stages I to IIIB non–small-cell lung cancer (NSCLC) who unde...
47 CitationsSource
#1Yasuhiro Koh (Wakayama Medical University)H-Index: 26
#2Tomoya Kawaguchi (OCU: Osaka City University)H-Index: 28
Last. Akihide MatsumuraH-Index: 29
view all 18 authors...
BACKGROUND: The epidermal growth factor receptor (EGFR) mutations have been used as a reliable predictor of response to EGFR tyrosine kinase inhibitor (TKI) treatment. Two common EGFR mutations (L858R, and exon19 deletion) and EGFR T790M mutation are clinically important for decision-making in clinical practice. Picodroplet digital PCR (ddPCR) has recently emerged as an accurate and ultra-sensitive method for tumor genotyping and have a great advantage over conventional mutation detection method...
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Abstract The case was 83-year-old man who had complete situs inversus, and was pointed out to have peripheral adenocarcinoma with the size of 1.8 cm at the left upper lobe( S3). Because of severe emphysema and other multiple comorbidities, left S3 segmentectomy with hilar lymph node sampling was performed using video-assisted thoracic surgery (VATS). Preoperatively, the simulation of operation was performed using the 3 dimension computed tomography images of pulmonary arteriovenous and bronchus ...
#1Yasuaki Enokida (Gunma University)H-Index: 5
#2Kimihiro Shimizu (Gunma University)H-Index: 33
Last. Izumi Takeyoshi (Gunma University)H-Index: 30
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The MDM2 protein plays an important role in the regulation of cell proliferation and apoptosis via ubiquitination and proteasome-mediated degradation of p53. The genetic polymorphism rs2279744 (c.309T>G) of the MDM2 gene is reportedly associated with susceptibility and/or prognosis in various cancers. In this study, we investigated the risk factors for worse survival in patients with lung adenocarcinoma (AC). We examined the association between c.309T>G and the prognosis of lung cancer by retros...
1 CitationsSource