Roberta Giordo
College of Health Sciences, Bahrain
Internal medicineDownregulation and upregulationEndocrinologyPathologyChemistryApoptosisIn vivoOxidative stressResveratrolAntioxidantHuman serum albuminDiseaseVascular smooth muscleCell damageMitochondrionProgrammed cell deathReactive oxygen speciesCancer researchBiochemistryOxidative phosphorylationCell growthPolyphenolMedicineIntracellularBiologyCell biology
31Publications
13H-index
860Citations
Publications 29
Newest
#1Roberta Giordo (College of Health Sciences, Bahrain)H-Index: 13
#2Yusra M. A. Ahmed (College of Health Sciences, Bahrain)
Last. Gianfranco Pintus (University of Sassari)H-Index: 32
view all 8 authors...
Diabetes-associated complications, such as retinopathy, nephropathy, cardiomyopathy, and atherosclerosis, the main consequences of long-term hyperglycemia, often lead to organ dysfunction, disability, and increased mortality. A common denominator of these complications is the myofibroblast-driven excessive deposition of extracellular matrix proteins. Although fibroblast appears to be the primary source of myofibroblasts, other cells, including endothelial cells, can generate myofibroblasts throu...
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#1Anna Maria PosadinoH-Index: 19
#2A CossuH-Index: 14
Last. Gianfranco PintusH-Index: 32
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This work aims to analyze the chemical and biological evaluation of two extracts obtained by olive mill wastewater (OMW), an olive oil processing byproduct. The exploitation of OMW is becoming an important aspect of development of the sustainable olive oil industry. Here we chemically and biologically evaluated one liquid (L) and one solid (S) extract obtained by liquid-liquid extraction followed by acidic hydrolysis (LLAC). Chemical characterization of the two extracts indicated that S has high...
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#1Lara Perrotta (University of Sassari)H-Index: 4
#2Roberta Giordo (University of Sassari)H-Index: 13
Last. Diego Albani (University of Sassari)H-Index: 10
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E2F transcription factors are key components of the RB/E2F pathway that, through the action of cyclin-dependent kinases, regulates cell cycle progression in both plants and animals. Moreover, plant and animal E2Fs have also been shown to regulate other cellular functions in addition to cell proliferation. Based on structural and functional features, they can be divided into different classes that have been shown to act as activators or repressors of E2F-dependent genes. Among the first plant E2F...
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#2Panagiotis Paliogiannis (University of Sassari)H-Index: 18
Last. Gianfranco Pintus (University of Sassari)H-Index: 32
view all 9 authors...
Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an abnormal fibrotic response involving vast areas of the lungs. Given the poor knowledge of the mechanisms underpinning IPF onset and progression, a better understanding of the cellular processes and molecular pathways involved is essential for the development of effective therapies, currently lacking. Besides a number of e...
1 CitationsSource
#1Roberta Giordo (College of Health Sciences, Bahrain)H-Index: 13
#2Panagiotis Paliogiannis (University of Sassari)H-Index: 18
Last. Gianfranco Pintus (University of Sassari)H-Index: 32
view all 4 authors...
SARS-CoV-2 is the agent responsible for the coronavirus disease (COVID-19), which has been declared a pandemic by the World Health Organization. The clinical evolution of COVID-19 ranges from asymptomatic infection to death. Older people and patients with underlying medical conditions, particularly diabetes, cardiovascular and chronic respiratory diseases are more susceptible to develop severe forms of COVID-19. Significant endothelial damage has been reported in COVID-19 and growing evidence su...
2 CitationsSource
#1Roberta Giordo (College of Health Sciences, Bahrain)H-Index: 13
#2Angelo Zinellu (University of Sassari)H-Index: 31
Last. Gianfranco Pintus (College of Health Sciences, Bahrain)H-Index: 32
view all 4 authors...
Coagulation disorders, endotheliopathy and inflammation are the most common hallmarks in SARS-CoV-2 infection, largely determining COVID-19’s outcome and severity. Dysfunctions of endothelial cells and platelets are tightly linked in contributing to the systemic inflammatory response that appears to be both a cause and a consequence of COVID-19-associated coagulation disorders and thrombotic events. Indeed, elevated levels of circulating inflammatory cytokines are often associated with abnormal ...
1 CitationsSource
#1Roberta Giordo (College of Health Sciences, Bahrain)H-Index: 13
#2Gheyath K. Nasrallah (College of Health Sciences, Bahrain)H-Index: 26
Last. Gianfranco Pintus (College of Health Sciences, Bahrain)H-Index: 32
view all 7 authors...
Diabetes-associated long-term hyperglycaemia leads to oxidative stress-mediated fibrosis in different tissues and organs. Endothelial-to-mesenchymal-transition (EndMT) appears to play a role in diabetes-associated fibrotic conditions. Here, we investigate whether EndMT is implicated in the diabetic retinopathy fibrotic process and evaluate the possibility that resveratrol could counteract EndMT by inhibiting high glucose (HG)-induced increases in ROS. Primary Human Retinal Endothelial Cells (HRE...
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#1Roberta Giordo (Qatar University)H-Index: 13
#2Gheyath K. Nasrallah (Qatar University)H-Index: 26
Last. Gianfranco Pintus (College of Health Sciences, Bahrain)H-Index: 32
view all 5 authors...
Despite their wide industrial use, Zinc oxide (ZnO) nanoparticles (NPs) exhibit a high toxic potential while concerns of their health-related risks are still present, urging additional in vivo clarification studies. Oxidative stress is recognized as the primary trigger of NP-associated toxicity, suggesting antioxidants as a promising counteractive approach. Here, we investigated the protective effect of the natural antioxidant resveratrol against ZnO NP-induced toxicity in vivo using the zebrafi...
7 CitationsSource
#1Anna Maria Posadino (University of Sassari)H-Index: 19
#2Roberta Giordo (Qatar University)H-Index: 13
Last. Gianfranco Pintus (Qatar University)H-Index: 32
view all 8 authors...
Background: Dietary intake of natural antioxidants is thought to impart protection against oxidative-associated cardiovascular diseases. Despite many in vivo studies and clinical trials, this issue has not been conclusively resolved. Resveratrol (RES) is one of the most extensively studied dietary polyphenolic antioxidants. Paradoxically, we have previously demonstrated that high RES concentrations exert a pro-oxidant effect eventually elevating ROS levels leading to cell death. Here, we further...
11 CitationsSource
#1Alessandro Fois (University of Sassari)H-Index: 17
#2Anna Maria Posadino (University of Sassari)H-Index: 19
Last. Gianfranco Pintus (Qatar University)H-Index: 32
view all 10 authors...
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by an exacerbated fibrotic response. Although molecular and cellular determinants involved in the onset and progression of this devastating disease are largely unknown, an aberrant remodeling of the pulmonary vasculature appears to have implications in IPF pathogenesis. Here, we demonstrated for the first time that an increase of reactive oxygen species (ROS) generation induced by sera from IPF patients drives both colla...
15 CitationsSource