Michael C. Babin
Battelle Memorial Institute
PathologyGene expressionMedian lethal doseChemistryImmunologyAtropineOxonInflammationInhalationCyanideOrganophosphate poisoningOximeInhalation exposureObidoximeSulfur mustardEdemaToxicityAnesthesiaMedicineBiologyPharmacology
35Publications
12H-index
681Citations
Publications 35
Newest
#1Andrea DeSantis-Rodrigues (RU: Rutgers University)H-Index: 2
#2Rita A. Hahn (RU: Rutgers University)H-Index: 8
Last. Marion K. Gordon (RU: Rutgers University)H-Index: 21
view all 8 authors...
Amino-Plex (SM1997) is a spray or liquid cosmeceutical that has been used for skin dryness, aging, or sun exposure. Its formulation includes electrolytes, trace minerals, amino acids, peptides, nucleosides and nucleotides, all substances that are less than 10 kDa. It is designed to increase oxygen levels in cells, improve glucose transport, stimulate ATP synthesis, and stimulate collagen formation, actions that can help facilitate repair of damaged cells. It also supports collagen synthesis and ...
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#1Jillian M. Staugler (Battelle Memorial Institute)H-Index: 1
#2Michael C. Babin (Battelle Memorial Institute)H-Index: 12
Last. Mark R. Perry (Battelle Memorial Institute)H-Index: 4
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AbstractObjective: Cyanide is a highly toxic chemical, and acute exposure depletes cells and tissue of oxygen, depressing the respiratory, cardiovascular and neurological systems and potentially leading to death. Cyanide has been used as a weapon since ancient Rome and continues to pose a potential threat today. A well-characterized animal model is necessary for the development of novel methods of rapid detection and treatment. This manuscript describes the development of an inhalation exposure ...
5 CitationsSource
#1Christina M. Wilhelm (Battelle Memorial Institute)H-Index: 3
#2Thomas H. Snider (Battelle Memorial Institute)H-Index: 6
Last. David T. Yeung (NIH: National Institutes of Health)H-Index: 6
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Abstract Organophosphorus (OP) compounds, including pesticides and chemical warfare nerve agents (CWNA), are threats to the general population as possible weapons of terrorism or by accidental exposure whether through inadvertent release from manufacturing facilities or during transport. To mitigate the toxicities posed by these threats, a therapeutic regimen that is quick-acting and efficacious against a broad spectrum of OPs is highly desired. The work described herein sought to assess the pro...
7 CitationsSource
#1Robert A. Moyer (Battelle Memorial Institute)H-Index: 3
#2Kevin G. McGarry (Battelle Memorial Institute)H-Index: 4
Last. David T. Yeung (NIH: National Institutes of Health)H-Index: 6
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Abstract Phorate is a highly toxic agricultural pesticide currently in use throughout the world. Like many other organophosphorus (OP) pesticides, the primary mechanism of the acute toxicity of phorate is acetylcholinesterase (AChE) inhibition mediated by its bioactivated oxon metabolite. AChE reactivation is a critical aspect in the treatment of acute OP intoxication. Unfortunately, very little is currently known about the capacity of various oximes to rescue phorate oxon (PHO)-inhibited AChE. ...
6 CitationsSource
#1Dinelia Rivera-Burgos (Battelle Memorial Institute)H-Index: 5
#2Michael C. Babin (Battelle Memorial Institute)H-Index: 12
Last. Mark R. Perry (Battelle Memorial Institute)H-Index: 4
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AbstractCyanides are highly toxic compounds that have been used as weapons of terrorism throughout history. Cyanide (CN) is acutely toxic by all routes of administration; however, inhalation is the...
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#1Vikhyat S. Bebarta (University of Colorado Denver)H-Index: 25
#2Matthew K. Brittain (Battelle Memorial Institute)H-Index: 4
Last. Gerry R. Boss (UCSD: University of California, San Diego)H-Index: 56
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Study objective The 2 antidotes for acute cyanide poisoning in the United States must be administered by intravenous injection. In the out-of-hospital setting, intravenous injection is not practical, particularly for mass casualties, and intramuscular injection would be preferred. The purpose of this study is to determine whether sodium nitrite and sodium thiosulfate are effective cyanide antidotes when administered by intramuscular injection. Methods We used a randomized, nonblinded, parallel-g...
30 CitationsSource
#1Michael C. BabinH-Index: 12
#2Frances M ReidH-Index: 1
Last. David T. YeungH-Index: 6
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Abstract : Cyanide (CN) is ubiquitous in many living organisms, commonly used in manufacturing processes (dyes, pigments, chelating agents, various nitriles, monomers, resins, fibers, case hardening, electroplating, extraction of precious metals, and fumigation), observed in accidental poisonings from natural or manmade products (smoke inhalation, cyanogens in apple seeds, peach pits, cherry pits, etc.) and as a possible terror threat agent. A higher priority has been placed on CN treatment and ...
2 Citations
#1Frances M ReidH-Index: 1
#2David A. JettH-Index: 19
Last. Michael C. BabinH-Index: 12
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Abstract : Cyanide (CN) is ubiquitous in many living organisms, commonly used in manufacturing processes (dyes, pigments, chelating agents, various nitriles, monomers, resins, fibers, case hardening, electroplating, extraction of precious metals, and fumigation), observed in accidental poisonings from natural or manmade products (smoke inhalation, cyanogens in apple seeds, peach pits, cherry pits, etc.) and as a possible terror threat agent. A higher priority has been placed on CN treatment and ...
#1Thomas H. Snider (Battelle Memorial Institute)H-Index: 6
#2Michael C. Babin (Battelle Memorial Institute)H-Index: 12
Last. David T. Yeung (NIH: National Institutes of Health)H-Index: 6
view all 5 authors...
Anticholinesterases, such as organophosphorus pesticides and warfare nerve agents, present a significant health threat. Onset of symptoms after exposure can be rapid, requiring quick-acting, efficacious therapy to mitigate the effects. The goal of the current study was to identify the safest antidote with the highest therapeutic index (TI = oxime 24-hr LD50/oxime ED50) from a panel of four oximes deemed most efficacious in a previous study. The oximes tested were pralidoxime chloride (2-PAM Cl),...
10 CitationsSource
#1Matthew K. Brittain (Battelle Memorial Institute)H-Index: 4
#2Kevin G. McGarry (Battelle Memorial Institute)H-Index: 4
Last. David T. Yeung (NIH: National Institutes of Health)H-Index: 6
view all 7 authors...
Purpose:Aldicarb and methomyl are carbamate pesticides commonly implicated in human poisonings. The primary toxic mechanism of action for carbamate poisoning is cholinesterase (ChE) inhibition. As such, it is logical to assume that the currently accepted therapies for organophosphate poisoning (muscarinic antagonist atropine and the oxime acetylcholinesterase reactivator pralidoxime chloride [2-PAM Cl]) could afford therapeutic protection. However, oximes have been shown to be contraindicated fo...
5 CitationsSource