Siba P. Raychaudhuri
United States Department of Veterans Affairs
Internal medicinePathologyDermatologyTumor necrosis factor alphaPhysical therapyImmunologyT cellPsoriatic arthritisSynovial fluidInflammatory arthritisInflammationArthritisRheumatoid arthritisNerve growth factorCytokineDiseasePsoriasisPathogenesisCancer researchMedicineBiology
160Publications
47H-index
5,101Citations
Publications 158
Newest
#1Archana Maniar (UC Davis: University of California, Davis)H-Index: 4
Last. Siba P. RaychaudhuriH-Index: 47
view all 4 authors...
Source
#1Suravi Raychaudhuri (Stanford University)H-Index: 2
#1Suravi Raychaudhuri (VA: United States Department of Veterans Affairs)
Last. Siba P. RaychaudhuriH-Index: 47
view all 4 authors...
PURPOSE OF REVIEW The Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling proteins represent a group of intracellular kinase molecules that play a central role in the signaling pathways induced by cytokines, chemokines, and certain growth factors associated with systemic and local inflammation of autoimmune diseases including in Spondyloarthritis (SpA). Here, we will discuss (i) the functional significance of the JAK-STAT kinase cascades in the inflammatory-proli...
Source
#1Zhenrui Shi (SYSU: Sun Yat-sen University)H-Index: 9
#2Emma Garcia-Melchor (Glas.: University of Glasgow)H-Index: 4
Last. Samuel T Hwang (UC Davis: University of California, Davis)H-Index: 49
view all 16 authors...
OBJECTIVES To assess the involvement of the CCR6/CCL20 axis in psoriatic arthritis (PsA) and psoriasis (PsO) and to evaluate its potential as a therapeutic target. METHODS First, we quantified CCL20 levels in peripheral blood and synovial fluid of PsA patients and the presence of CCR6+ cells in synovial and tendon tissue. Utilizing an IL-23 minicircle DNA (MC) mouse model exhibiting key features of both PsO and PsA, we investigated CCR6 and CCL20 expression and the preventive and therapeutical e...
1 CitationsSource
#1Arthur KavanaughH-Index: 85
#2A. IshchenkoH-Index: 1
Last. Samuel T HwangH-Index: 49
view all 7 authors...
A summary of the research conducted by the recipients of the 2019 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) Research Awards is presented. Dr. Alla Ishchenko's project was "Role of Metabolomics in Diagnosis, Disease Severity, and Progression in Psoriasis and Psoriatic Arthritis: A 2-year Prospective Pilot Study" and Dr. Zhenrui Shi's project was "Preclinical Analysis of CCR6 and CCL20 in Mouse and Human Joints, Respectively, as Targets of Therapeutic Interven...
1 CitationsSource
#1Philip J. Mease (UW: University of Washington)H-Index: 103
#2Saima ChohanH-Index: 2
Last. Alice B. Gottlieb (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 111
view all 10 authors...
OBJECTIVES To evaluate efficacy and safety of the anti-interleukin-23p19 monoclonal antibody tildrakizumab in patients with psoriatic arthritis (PsA). METHODS In this randomised, double-blind, placebo-controlled, phase IIb study, patients with active PsA were randomised 1:1:1:1:1 to tildrakizumab 200 mg every 4 weeks (Q4W); tildrakizumab 200, 100 or 20 mg Q12W; or placebo Q4W. Patients receiving tildrakizumab 20 mg or placebo switched to tildrakizumab 200 mg Q12W at W24; treatment continued to W...
1 CitationsSource
#1Yasser Abdelhafez (UC Davis: University of California, Davis)H-Index: 5
#2Heather Hunt (UC Davis: University of California, Davis)H-Index: 1
Last. Abhijit J. Chaudhari (UC Davis: University of California, Davis)H-Index: 18
view all 10 authors...
1697 Purpose: Total-body PET/CT scanners offer the unique ability to evaluate the systemic inflammatory burden of autoimmune inflammatory arthritic (AIA) conditions using ultra-low dose protocols. However, AIA patients are unable to tolerate long scan times. We prospectively evaluated the influence of shortening the scan time on image quality in participants with AIA and non-AIA controls using a total-body PET/CT scanner. Methods: Participants with an established AIA condition (Rheumatoid Arthri...
#1Zhenrui Shi (UC Davis: University of California, Davis)H-Index: 9
#2Emma Garcia-Melchor (Glas.: University of Glasgow)H-Index: 4
Last. Samuel T Hwang (UC Davis: University of California, Davis)H-Index: 49
view all 11 authors...
Abstract CC chemokine receptor 6 (CCR6) is important for the trafficking of IL-17A-producing γδ T cells and required for the development of psoriasiform dermatitis (PsD) in an IL-23 intradermal injection model. The role of CCR6, however, in IL-23-mediated joint inflammation is unclear. We herein hydrodynamically delivered IL-23 minicircle DNA into wild-type (WT) and CCR6-deficient (CCR6-KO) mice to induce overexpression of IL-23 systemically. After IL-23 gene transfer, WT mice exhibited concurre...
3 CitationsSource
#1Atrin Toussi (UC Davis: University of California, Davis)H-Index: 5
#2Natalia Maverakis (NYU: New York University)H-Index: 2
Last. Siba P. Raychaudhuri (UC Davis: University of California, Davis)H-Index: 47
view all 6 authors...
Abstract Psoriatic arthritis (PsA) is a large volume of our clinical practice and its management can be challenging. Traditional DMARDs have been used over last six decades and observational studies have substantiated an effective use of many of these drugs. However, in last two decades use of anti-TNF agents has brought a new dimension in treatment of PsA and may other autoimmune diseases. Regulatory role of the Th17 cells and its cytokines in the pathogenesis of PsA has successfully paved the ...
5 CitationsSource
#1Stephanie T. Le (UC Davis: University of California, Davis)H-Index: 5
#2Atrin Toussi (UC Davis: University of California, Davis)H-Index: 5
Last. Emanual Michael Maverakis (UC Davis: University of California, Davis)H-Index: 35
view all 9 authors...
Psoriasis (PsO) and psoriatic arthritis (PsA) are chronic immune-mediated inflammatory diseases of multifactorial etiology. In addition to genetic and environmental factors, evidence supports involvement of a dysregulated human microbiome in the pathogenesis of psoriatic disease. In particular, alterations in the composition of the microbiome, termed dysbiosis, can result in downstream proinflammatory effects in the gut, skin, and joints. Both the cutaneous and intestinal microbial populations a...
1 CitationsSource
#1Priya Duggal (UC Davis: University of California, Davis)
#2Swati Shripad Patki (UC Davis: University of California, Davis)
Last. Siba P. Raychaudhuri (UC Davis: University of California, Davis)H-Index: 47
view all 5 authors...
Source