Francesco Casanova
University of Exeter
VasodilationInternal medicineBiomedical engineeringPathologyUltrasoundCardiologyHemodynamicsPhysical therapyMaterials scienceEchogenicityArterial stiffnessEndotheliumType 2 diabetesRheumatoid arthritisBrachial arteryCachexiaPulse wave velocityBone tissueDiseasePopulationCarotid arteriesReservoir pressureStep testOlder populationAnesthesiaNear-infrared spectroscopyWeight lossDiabetes mellitusMedicineCohortBlood pressureBiology
48Publications
11H-index
495Citations
Publications 47
Newest
#1Jessica O'Loughlin (University of Exeter)
#2Francesco Casanova (University of Exeter)H-Index: 11
Last. Sean W. Cain (Monash University, Clayton campus)H-Index: 23
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Late diurnal preference has been linked to poorer mental health outcomes, but the understanding of the causal role of diurnal preference on mental health and wellbeing is currently limited. Late diurnal preference is often associated with circadian misalignment (a mismatch between the timing of the endogenous circadian system and behavioural rhythms), so that evening people live more frequently against their internal clock. This study aims to quantify the causal contribution of diurnal preferenc...
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#1Manuela Cresswell (RD&E: Royal Devon and Exeter Hospital)
#2Francesco CasanovaH-Index: 11
Last. Jess TyrrellH-Index: 7
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OBJECTIVES To investigate the causal role of established risk factors and associated conditions to tinnitus and tinnitus severity in the UK Biobank. DESIGN The prospective cohort study with large dataset of >500,000 individuals. The analytical sample of 129,731 individuals in the UK Biobank of European descent. Participants were recruited from National Health Service registries, baseline age range between 37 and 73 years, response rate to baseline survey 6%. Participants were asked subjective qu...
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#1Kunihiko Aizawa (University of Exeter)H-Index: 9
#2Francesco Casanova (University of Exeter)H-Index: 11
Last. Alun D. Hughes (UCL: University College London)H-Index: 82
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The parameters derived from reservoir-excess pressure analysis have prognostic utility in several populations. However, evidence in type 2 diabetes (T2DM) remains scarce. We determined if these parameters were associated with T2DM and whether they would predict cardiovascular events in individuals with T2DM. We studied 306 people with T2DM with cardiovascular disease (CVD; DMCVD, 70.4±7.8 years), 348 people with T2DM but without CVD (diabetes mellitus, 67.7±8.4 years), and 178 people without T2D...
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#1Kunihiko AizawaH-Index: 9
#2Francesco CasanovaH-Index: 11
Last. Alun D. HughesH-Index: 82
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#1Francesco Casanova (RD&E: Royal Devon and Exeter Hospital)H-Index: 11
#2Kim M. Gooding (RD&E: Royal Devon and Exeter Hospital)H-Index: 1
Last. W David Strain (RD&E: Royal Devon and Exeter Hospital)
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Although cardiovascular disease is the biggest cause of death in people with diabetes, microvascular complications have a significant impact on quality of life and financial burden of the disease. Little is known about the progression of microvascular dysfunction in the early stages of type 2 diabetes before the occurrence of clinically apparent complications. We aimed to explore the determinants of endothelial-dependent and -independent microvascular function progression over a 3 year period, i...
1 CitationsSource
#1Kunihiko AizawaH-Index: 9
#2Francesco CasanovaH-Index: 11
Last. Angela C. ShoreH-Index: 58
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#1Francesco Casanova (University of Exeter)H-Index: 11
#2Andrew R. Wood (University of Exeter)H-Index: 76
Last. Jessica Tyrrell (University of Exeter)H-Index: 34
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Urinary albumin-creatinine ratio is a marker of diabetic nephropathy and microvascular damage. Metabolic-related traits are observationally associated with ACR but their causal role is uncertain. Here, we confirmed ACR as a marker of microvascular damage and tested whether metabolic-related traits have causal relationships with ACR. The association between ACR and microvascular function (responses to acetylcholine and sodium nitroprusside) were tested in the SUMMIT study. Two sample Mendelian ra...
3 CitationsSource
#1Francesco Casanova (University of Exeter)H-Index: 11
#2Jessica Tyrrell (University of Exeter)H-Index: 34
Last. Andrew R. Wood (University of Exeter)H-Index: 76
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Raised albumin-creatinine ratio (ACR) is an indicator of microvascular damage and renal disease. We aimed to identify genetic variants associated with raised ACR and study the implications of carrying multiple ACR-raising alleles with metabolic and vascular-related disease. We performed a genome-wide association study of ACR using 437 027 individuals from the UK Biobank in the discovery phase, 54 527 more than previous studies, and followed up our findings in independent studies. We identified 6...
5 CitationsSource
#1Kunihiko Aizawa (University of Exeter)H-Index: 9
#2Alessandro Ramalli (UniFI: University of Florence)H-Index: 18
Last. Carlo Palombo (UniPi: University of Pisa)H-Index: 37
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KEY POINTS: The vasodilatory response to reactive hyperaemia is impaired with advancing age, but it is unclear whether this is because of an altered wall shear rate (WSR) stimulus or an altered flow-mediated dilatation (FMD) response. Using new technology that allows detailed WSR measurement, we assessed the WSR-FMD response in healthy older people. Our data show that older people have a markedly altered and diminished WSR response to reactive hyperaemia compared to young people, but reduced WSR...
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