Fergus V. Gleeson
University of Oxford
CancerInternal medicineRadiologyPET-CTSurgeryPathologyMagnetic resonance imagingUltrasoundOncologyArtificial intelligencePositron emission tomographyBiopsyRespiratory diseaseLung cancerPleural diseaseLungDiseaseMalignancyNuclear medicineComputed tomographyMedicine
Publications 376
#1Paul C. Lyon (University of Oxford)H-Index: 8
#2Christophoros Mannaris (University of Oxford)H-Index: 11
Last. Constantin C. Coussios (University of Oxford)H-Index: 41
view all 8 authors...
Abstract Lyso-thermosensitive liposomes (LTSLs) are specifically designed to release chemotherapy agents under conditions of mild hyperthermia. Preclinical studies have indicated that magnetic resonance (MR)-guided focused ultrasound (FUS) systems can generate well-controlled volumetric hyperthermia using real-time thermometry. However, high-throughput clinical translation of these approaches for drug delivery is challenging, not least because of the significant cost overhead of MR guidance and ...
1 CitationsSource
#1Andrew White (PHE: Public Health England)H-Index: 11
#2Laura Sibley (PHE: Public Health England)H-Index: 8
Last. Alessandro Sette (La Jolla Institute for Allergy and Immunology)H-Index: 165
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A single intradermal vaccination with MTBVAC given to adult rhesus macaques was well tolerated and conferred a significant improvement in outcome following aerosol exposure to M. tuberculosis compared to that provided by a single BCG vaccination. Vaccination with MTBVAC resulted in a significant reduction in M. tuberculosis infection-induced disease pathology measured using in vivo medical imaging, in gross pathology lesion counts and pathology scores recorded at necropsy, the frequency and seve...
3 CitationsSource
#1Susanne RauchH-Index: 5
#1Susanne RauchH-Index: 3
Last. Miles W. Carroll (PHE: Public Health England)H-Index: 32
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The ongoing severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic necessitates the fast development of vaccines to meet a worldwide need. mRNA-based vaccines are the most promising technology for rapid and safe SARS-CoV-2 vaccine development and production. We have designed CVnCoV, a lipid-nanoparticle (LNP) encapsulated, sequence optimised mRNA-based SARS-CoV-2 vaccine that encodes for full length, pre-fusion stabilised Spike protein. Unlike other mRNA-based approaches, CVnCoV e...
7 CitationsSource
#1Kevin R. Bewley (PHE: Public Health England)H-Index: 17
#2Karen E. Gooch (PHE: Public Health England)H-Index: 9
Last. Miles W. Carroll (University of Oxford)H-Index: 32
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There is an urgent requirement for safe and effective vaccines to prevent novel coronavirus disease (COVID-19) caused by SARS-CoV-2. A concern for the development of new viral vaccines is the potential to induce vaccine-enhanced disease (VED). This was reported in several preclinical studies with both SARS-CoV-1 and MERS vaccines but has not been reported with SARS-CoV-2 vaccines. We have used ferret and rhesus macaques challenged with SARS-CoV-2 to assess the potential for VED in animals vaccin...
#1Francisco J. Salguero (PHE: Public Health England)H-Index: 34
#2Andrew White (PHE: Public Health England)H-Index: 11
Last. Miles W. Carroll (PHE: Public Health England)H-Index: 32
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ABSTRACT A novel coronavirus, SARS-CoV-2, has been identified as the causative agent of the current COVID-19 pandemic. Animal models, and in particular non-human primates, are essential to understand the pathogenesis of emerging diseases and to the safety and efficacy of novel vaccines and therapeutics. Here, we show that SARS-CoV-2 replicates in the upper and lower respiratory tract and causes pulmonary lesions in both rhesus and cynomolgus macaques, resembling the mild clinical cases of COVID-...
2 CitationsSource
#1Maria Tsakok (John Radcliffe Hospital)H-Index: 7
#1Maria Tsakok (John Radcliffe Hospital)H-Index: 2
Last. Fergus Gleeson (John Radcliffe Hospital)H-Index: 6
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Objective:The chest radiograph (CXR) is the predominant imaging investigation being used to triage patients prior to either performing a SARS-CoV-2 polymerase chain reaction (PCR) test or a diagnos...
#1K. Fatania (Leeds Teaching Hospitals NHS Trust)
#2P.J. Brown (Leeds Teaching Hospitals NHS Trust)H-Index: 2
Last. Andrew Scarsbrook (University of Leeds)H-Index: 8
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AIM To compare the interobserver reliability and diagnostic accuracy of the British Thoracic Society (BTS) scale and other visual assessment criteria in the context of 2-[18F]-fluoro-2-deoxy- d- glucose (FDG) positron-emission tomography (PET)-computed tomography (CT) evaluation of solid pulmonary nodules (SPNs). MATERIALS AND METHODS Fifty patients who underwent FDG PET-CT for assessment of a SPN were identified. Seven reporters with varied experience at four centres graded FDG uptake visually ...
#1Pierre P. Massion (Vandy: Vanderbilt University)H-Index: 65
#2Sanja L. Antic (Vandy: Vanderbilt University)H-Index: 4
Last. Fergus V. Gleeson (University of Oxford)H-Index: 58
view all 20 authors...
Rationale: The management indeterminate pulmonary nodules (IPNs) remains challenging, resulting in invasive procedures and delays in diagnosis and treatment. Strategies to decrease the rate of unne...
15 CitationsSource