Nazlee Sharmin
University of Alberta
Heterologous expressionTransmembrane domainPhysicsBiophysicsHelixEndogenyDomain (software engineering)Membrane potentialChemistrySensitivity (control systems)Electronic engineeringDisinhibitionLoop (topology)LinkerAmino acid transporterVoltage sensingVoltage-gated ion channelComputer scienceProtein structureMultimediaIon channelMolecular dynamicsCrystallographyPotassium channel
13Publications
3H-index
25Citations
Publications 13
Newest
#1Ava K. Chow (U of A: University of Alberta)H-Index: 9
#2Nazlee Sharmin (U of A: University of Alberta)H-Index: 3
Objectives null The knowledge of anatomy is an integral part of dental and medical education that builds the foundations of pathology, physiology, and other related disciplines. Traditional three-dimensional (3D) models used to teach anatomy cannot represent dynamic physiological processes and lack structural detail in the oral regions relevant for dental education. We developed an interactive computer program to teach oral anatomy, pathology, and microbiology in an integrated manner to improve ...
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#1Nazlee Sharmin (U of A: University of Alberta)H-Index: 3
#2Ava K. Chow (U of A: University of Alberta)H-Index: 9
Last. Nadine C. Milos (U of A: University of Alberta)H-Index: 12
view all 4 authors...
OBJECTIVES Histology, the study of tissue structure under a microscope, is one of the most essential yet least engaging topics for health professional students. Understanding tissue microanatomy is crucial for students to be able to recognize cellular structures and follow disease pathogenesis. Traditional histology teaching labs rely on light microscopes and a limited array of slides, which inhibits simultaneous observation by multiple learners, and prevents in-class discussions. We have develo...
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#1Shawn M. Lamothe (U of A: University of Alberta)H-Index: 8
#2Nazlee Sharmin (U of A: University of Alberta)H-Index: 3
Last. Harley T. Kurata (U of A: University of Alberta)H-Index: 21
view all 8 authors...
Many voltage-dependent ion channels are regulated by accessory proteins. We recently reported powerful regulation of Kv1.2 potassium channels by the amino acid transporter Slc7a5. In this study, we report that Kv1.1 channels are also regulated by Slc7a5, albeit with different functional outcomes. In heterologous expression systems, Kv1.1 exhibits prominent current enhancement ('disinhibition') with holding potentials more negative than -120 mV. Knockdown of endogenous Slc7a5 leads to larger Kv1....
Source
#1Nazlee Sharmin (U of A: University of Alberta)H-Index: 3
#2Ava K. Chow (U of A: University of Alberta)H-Index: 9
Objective Flashcards are one of the most popular and optimized ways to learn factual knowledge and improve memory performance. Students of modern age, who use smart technology and mobile devices in their daily lives, often lack the time and motivation to create and use flashcards effectively. We aim to use the inseparable relationship between university students and their smartphones to create new options for higher education, converting their cellphones into flashcards. We have used this new te...
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#1Shawn M. Lamothe (U of A: University of Alberta)H-Index: 8
#2Nazlee Sharmin (U of A: University of Alberta)H-Index: 3
Last. Harley T. Kurata (U of A: University of Alberta)H-Index: 21
view all 8 authors...
Source
#1Shawn M. LamotheH-Index: 8
#2Nazlee SharminH-Index: 3
Last. Harley T. KurataH-Index: 21
view all 6 authors...
Source
#1Nazlee Sharmin (U of A: University of Alberta)H-Index: 3
#2Shawn M. Lamothe (U of A: University of Alberta)H-Index: 8
Last. Harley T. Kurata (U of A: University of Alberta)H-Index: 21
view all 6 authors...
Many voltage-dependent ion channels are regulated by accessory proteins, although the underlying mechanisms and consequences are often poorly understood. We recently reported a novel function of the amino acid transporter Slc7a5 as a powerful regulator of Kv1.2 voltage-dependent activation. In this study, we report that Kv1.1 channels are also regulated by Slc7a5, albeit with different functional outcomes. In heterologous expression systems, Kv1.1 exhibits prominent current enhancement (9disinhi...
Source
#1Alice W. Wang (U of A: University of Alberta)H-Index: 3
#2Michael C. Yau (UCPH: University of Copenhagen)H-Index: 3
Last. Harley T. Kurata (U of A: University of Alberta)H-Index: 21
view all 7 authors...
KCNQ2-5 (Kv7.2–Kv7.5) channels are strongly influenced by an emerging class of small-molecule channel activators. Retigabine is the prototypical KCNQ activator that is thought to bind within the pore. It requires the presence of a Trp side chain that is conserved among retigabine-sensitive channels but absent in the retigabine-insensitive KCNQ1 subtype. Recent work has demonstrated that certain KCNQ openers are insensitive to mutations of this conserved Trp, and that their effects are instead ab...
Source
#1Nazlee Sharmin (U of A: University of Alberta)H-Index: 3
#2Warren J. Gallin (U of A: University of Alberta)H-Index: 25
ABSTRACT Voltage-gated potassium ion (Kv) channel proteins respond to changes in membrane potential by changing the probability of K+ flux through an ion-selective pore. Kv channels from different paralogous and orthologous families have widely varying V50 values. The voltage-sensing transmembrane helices (S4) of different channels contain four to seven basic residues that are responsible for transducing changes in transmembrane potential into the energy required to shift the equilibrium between...
Source
#1Nazlee Sharmin (U of A: University of Alberta)H-Index: 3
#2Matthias Ostermaier (U of A: University of Alberta)
Last. Warren J. Gallin (U of A: University of Alberta)H-Index: 25
view all 3 authors...
Voltage gated potassium ion (Kv) channels are trans-membrane proteins that open and close their ion selective pore in response to changes in membrane voltage. Three negatively charged residues in the S2 and S3 helices are conserved in most Kv channels and form an electrostatic interaction network with positively charged residues of the S4, voltage sensing, helix. Previous studies with mouse Kv1.2 have shown that the length and composition of the S3-S4 linker are important in shaping the voltage ...
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