Edward M. Schaeffer
Northwestern University
CancerInternal medicineUrologySurgeryPathologyOncologyBiopsyProstateBiochemical recurrenceMetastasisDiseaseProstatectomyMEDLINEProstate cancerProstate-specific antigenCancer researchMedicineCohortUrinary systemBiology
Publications 579
#6Marin SekosanH-Index: 17
#1Matthew T. Hudnall (NU: Northwestern University)H-Index: 2
#2Anuj S. Desai (NU: Northwestern University)H-Index: 6
Last. Shilajit Kundu (NU: Northwestern University)H-Index: 24
view all 9 authors...
BACKGROUND Despite consensus guidelines, many men with low-grade prostate cancer are not managed with active surveillance. Patient perception of the nomenclature used to describe low-grade prostate cancers may partly explain this discrepancy. METHODS A randomized online survey was administered to men without a history of prostate cancer, presenting a hypothetical clinical scenario in which they are given a new diagnosis of low-grade prostate cancer. The authors determined whether diagnosis nomen...
#1Walter RayfordH-Index: 5
#1Walter RayfordH-Index: 18
Last. Ashutosh K. Tewari (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 44
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Racial disparities in prostate cancer have not been well characterized on a genomic level. Here we show the results of a multi-institutional retrospective analysis of 1,152 patients (596 African-American men (AAM) and 556 European-American men (EAM)) who underwent radical prostatectomy. Comparative analyses between the race groups were conducted at the clinical, genomic, pathway, molecular subtype, and prognostic levels. The EAM group had increased ERG (P < 0.001) and ETS (P = 0.02) expression, ...
#1Xintao Qiu (Harvard University)H-Index: 12
#2Nadia BoufaiedH-Index: 5
Last. David P. LabbéH-Index: 21
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c-MYC (MYC) is a major driver of prostate cancer tumorigenesis and progression. Although MYC is overexpressed in both early and metastatic disease and associated with poor survival, its impact on prostate transcriptional reprogramming remains elusive. We demonstrate that MYC overexpression significantly diminishes the androgen receptor (AR) transcriptional program (the set of genes directly targeted by the AR protein) in luminal prostate cells without altering AR expression. Importantly, analyse...
#1Adam B. Weiner (NU: Northwestern University)H-Index: 14
#2Eric V. Li (NU: Northwestern University)H-Index: 2
Last. Edward M. Schaeffer (NU: Northwestern University)H-Index: 59
view all 5 authors...
BACKGROUND More than 3.6 million men in the United States harbor a diagnosis of prostate cancer (PCa). The authors sought to provide in-depth analyses of the causes of death for contemporary survivors. METHODS The authors performed a population-based cohort study in the United States (2000-2016) to assess causes of death for men diagnosed with PCa stratified by demographics and tumor stage. Using general population data, they calculated standardized mortality ratios (SMRs) as observed-to-expecte...
1 CitationsSource
#1Carissa Chu (UCSF: University of California, San Francisco)H-Index: 9
#2Mohammed Alshalalfa (UCSF: University of California, San Francisco)H-Index: 2
Last. Felix Y. Feng (UCSF: University of California, San Francisco)H-Index: 78
view all 22 authors...
Abstract 18F-Fluciclovine-based positron emission tomography (PET) imaging is recommended in the USA for biochemical recurrence (BCR) after prostate cancer treatment. However, prostate-specific membrane antigen (PSMA)-based PET imaging is more common worldwide, supported by international guidelines, and is now approved by the Food and Drug Administration in the USA for initial staging of primary prostate cancer. Little is known about the molecular profiles of lesions detected by PSMA-targeted PE...
#1Yang Yi (NU: Northwestern University)H-Index: 5
#2Yanqiang Li (Harvard University)
Last. Qi Cao (NU: Northwestern University)H-Index: 33
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Dysregulated translation is a common feature of cancer. Uncovering its governing factors and underlying mechanism are important for cancer therapy. Here, we report that enhancer of zeste homologue 2 (EZH2), previously known as a transcription repressor and lysine methyltransferase, can directly interact with fibrillarin (FBL) to exert its role in translational regulation. We demonstrate that EZH2 enhances rRNA 2′-O methylation via its direct interaction with FBL. Mechanistically, EZH2 strengthen...
1 CitationsSource
#1Spyridon P Basourakos (Cornell University)H-Index: 3
#1Spyridon P Basourakos (Cornell University)H-Index: 1
Last. Michael A Gorin (University of Pittsburgh)H-Index: 1
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New technical modifications enable transperineal prostate biopsy to be performed in the ambulatory setting under local anaesthesia. Although a variety of techniques for administration of local anaesthetic during transperineal prostate biopsy have been described, no consensus exists regarding the most effective method to use. Thus, ample opportunity exists for procedural innovation and future study on this topic.
#1Laila A. Gharzai (UM: University of Michigan)H-Index: 5
#2Ralph Jiang (UM: University of Michigan)H-Index: 1
Last. Daniel E. Spratt (UM: University of Michigan)H-Index: 50
view all 25 authors...
Summary Background The international Intermediate Clinical Endpoints in Cancer of the Prostate working group has established metastasis-free survival as a surrogate for overall survival in localised prostate cancer based on the findings of 19 predominantly radiotherapy-based trials. We sought to comprehensively assess aggregate trial-level performance of commonly reported intermediate clinical endpoints across all randomised trials in localised prostate cancer. Methods For this meta-analysis, we...
1 CitationsSource