Roberto Bortolotti
Internal medicineOdds ratioDermatologyRetrospective cohort studyRandomized controlled trialAdverse effectRheumatologyImmunologyVasculitisRheumatoid factorPsoriatic arthritisLymphoproliferative disordersArthritisAnkylosing spondylitisInterstitial lung diseaseRheumatoid arthritisMicroscopic polyangiitisDiseaseAdalimumabRituximabGranulomatosis with polyangiitisRisk factorMedicineCohortGastroenterology
Publications 31
#2Antonio VitaleH-Index: 30
Last. Micol FrassiH-Index: 20
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#1Alvise Berti (Mayo Clinic)H-Index: 17
#2Roberto BortolottiH-Index: 7
Last. Antonello VecciaH-Index: 14
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INTRODUCTION The introduction in clinical practice of the immune checkpoint inhibitors (ICIs) radically changed the treatment algorithm of lung cancers. To characterize the toxicity of ICIs (atezolizumab, durvalumab, nivolumab, pembrolizumab) is important for personalizing treatment. PATIENTS AND METHODS We performed a systematic review and meta-analysis of phase III randomized controlled trials assessing ICIs, from inception until April 23rd, 2020. We extracted the data from the ICI arm of each...
#1Sara MontiH-Index: 28
#2Lorenzo Dagna (UniSR: Vita-Salute San Raffaele University)H-Index: 37
Last. Carlomaurizio MontecuccoH-Index: 74
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Background: Giant cell arteritis (GCA) is the most frequent systemic vasculitis after the age of 50 years old. Recent interest in the processes of immune and vascular aging have been proposed as a disease risk factor. Data on the impact of age at diagnosis of GCA on the clinical course of the disease are scarce Objectives: To assess the role of age at diagnosis of GCA on the risk and time to relapse Methods: Centres participating in the Italian Society of Rheumatology Vasculitis Study Group retr...
#1Alarico ArianiH-Index: 10
#2E. BraviH-Index: 7
Last. Carlo Alberto Scirè (University of Ferrara)H-Index: 32
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Background: Interstitial lung disease (ILD) is the main cause of death in Systemic Sclerosis (SSc). Chest CT is the gold standard in detecting ILD although it is not easy to understand its prognostic value. ILD qualitative assessment is almost worthless. Goh et al. semi quantitative score of ILD extent is related to mortality risk but it is burdened by relevant inter/intra-readers variability. An operator independent algorithm based on voxel-wise analysis proved to identify SSc patients with an ...
Background: The prospective, US-based, observational Corrona PsA/SpA Registry collects real-world data on patients (pts) with PsA provided by pts and their providers. Objectives: To examine trends in characteristics of pts initiating apremilast (APR) from 2014-2019 and compare characteristics of treatment-naive pts initiating APR or methotrexate (MTX). Methods: PsA pts aged ≥18 yrs enrolled in the registry who initiated APR, MTX, and/or biologics for PsA from January 2014-August 2019 were includ...
#1Alvise BertiH-Index: 17
#2Milena BondH-Index: 6
Last. Giuseppe PaolazziH-Index: 20
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Primary systemic vasculitides are rare diseases affecting blood vessel walls. The type and patterns of distribution of the organs affected usually reflect the size of the vessels predominantly involved, and the patterns of clinical manifestations are generally useful to reach a specific diagnosis. However, presenting symptoms may lack adequate specificity for a prompt diagnosis, leading to a diagnostic (and therapeutic) delay, often causing irreversible damage to the affected organs. Due to thei...
1 CitationsSource
#1Alvise Berti (University of Trento)H-Index: 17
#2Mara Felicetti (UNIPD: University of Padua)H-Index: 11
Last. Giuseppe PaolazziH-Index: 20
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Abstract Objective Aging may be a risk factor for morbidity in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We compared the rate and better characterized the type of disease- and treatment-related complications affecting young and elderly patients with AAV. Methods All new cases of granulomatosis with polyangiitis or microscopic polyangiitis diagnosed in three referral centers between 2000-2016 were included. Patients were stratified by age into young or elderly ( Res...
4 CitationsSource
#1Luca QuartuccioH-Index: 39
#2Milena BondH-Index: 6
Last. Salvatore De VitaH-Index: 24
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Abstract Introduction Alveolar haemorrhage (AH) is considered an important cause of morbidity and early mortality in anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitides (AAV). Objectives The aim of this study was to identify predictors of outcome in patients with AH-AAV and to evaluate outcome and causes of death in this subset. Materials and methods A multicenter retrospective study was conducted in 29 Italian Centers. Clinicians were asked to recruit all patients diagnosed wi...
7 CitationsSource
OBJECTIVES: The aim of this study was to develop a Delphi consensus statement between rheumatologists and radiologists for the diagnosis and monitoring of axial spondyloarthritis (axial-SpA). METHODS: Following an extensive literature search to identify unmet needs and potential goals for a multidisciplinary approach, a scientific board comprising 28 Italian hospital-based rheumatologists (n=19) and radiologists (n=9) identified 8 "starting points", resulting in the development of 23 consensus s...
5 Citations
#1Alvise BertiH-Index: 17
#2Mara FelicettiH-Index: 11
Last. Giuseppe PaolazziH-Index: 20
view all 11 authors...
Background: Advancing age may be a risk factor for morbidity in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Objectives: We aimed to compare the rates and better characterize the type of disease- and treatment-related complications affecting young and elderly patients with AAV. Methods: All new cases of granulomatosis with polyangiits or microscopic polyangiitis diagnosed between 2000 and 2016 in three referral centers in Northern Italy were included. Patients were st...