Steffen Goerke
German Cancer Research Center
SignalNuclear Overhauser effectPhysicsInternal medicineBiomedical engineeringMagnetic resonance imagingOncologySaturation (magnetic)Aqueous solutionChemistryMaterials scienceIn vivoGlioblastomaContrast (vision)Human brainGliomaCreatineMagnetization transferAcquisition ProtocolNuclear medicineSaturation transferChemical exchangeCest mriComputer scienceNuclear magnetic resonanceProtonSpillover effectMedicineArrhenius equationActivation energy
39Publications
14H-index
665Citations
Publications 31
Newest
#1Maximilian N. Voelker (Erwin L. Hahn Institute for Magnetic Resonance Imaging)H-Index: 3
#2Oliver Kraff (Erwin L. Hahn Institute for Magnetic Resonance Imaging)H-Index: 25
Last. Harald H. Quick (University of Duisburg-Essen)H-Index: 55
view all 23 authors...
Abstract Object This study evaluates inter-site and intra-site reproducibility at ten different 7 T sites for quantitative brain imaging. Material and Methods Two subjects – termed the “traveling heads” – were imaged at ten different 7 T sites with a harmonized quantitative brain MR imaging protocol. In conjunction with the system calibration, MP2RAGE, QSM, CEST and multi-parametric mapping/relaxometry were examined. Results Quantitative measurements with MP2RAGE showed very high reproducibility...
2 CitationsSource
#1Steffen Goerke (DKFZ: German Cancer Research Center)H-Index: 14
#2Johannes Breitling (DKFZ: German Cancer Research Center)H-Index: 5
Last. P Bachert (Heidelberg University)
view all 8 authors...
PURPOSE The value of relaxation-compensated amide proton transfer (APT) and relayed nuclear Overhauser effect (rNOE) chemical exchange saturation transfer (CEST)-MRI has already been demonstrated in various neuro-oncological clinical applications. Recently, we translated the approach from 7T to a clinically relevant magnetic field strength of 3T. However, the overall acquisition time was still too long for a broad application in the clinical setting. The aim of this study was to establish a shor...
1 CitationsSource
#1Lisa Loi (DKFZ: German Cancer Research Center)H-Index: 3
#2Ferdinand Zimmermann (Heidelberg University)H-Index: 3
Last. Daniel Paech (DKFZ: German Cancer Research Center)H-Index: 20
view all 13 authors...
Abstract Purpose To investigate whether fat-corrected and relaxation-compensated amide proton transfer (APT) and guanidyl CEST-MRI enables the detection of signal intensity differences between breast tumors and normal-appearing fibroglandular tissue in patients with newly-diagnosed breast cancer. Method Ten patients with newly-diagnosed breast cancer and seven healthy volunteers were included in this prospective IRB-approved study. CEST-MRI was performed on a 7 T-whole-body scanner followed by a...
6 CitationsSource
#1Dennis Kleimaier (Heidelberg University)H-Index: 3
#2Steffen Goerke (DKFZ: German Cancer Research Center)H-Index: 14
Last. Lothar R. Schad (Heidelberg University)H-Index: 66
view all 9 authors...
CEST-MRI of the rNOE signal has been demonstrated in vitro to be closely linked to the protein conformational state. As the detectability of denaturation and aggregation processes on a physiologically relevant scale in living organisms has yet to be verified, the aim of this study was to perform heat-shock experiments with living cells to monitor the cellular heat-shock response of the rNOE CEST signal. Cancer cells (HepG2) were dynamically investigated after a mild, non-lethal heat-shock of 42 ...
6 CitationsSource
#1Philip S. Boyd (DKFZ: German Cancer Research Center)H-Index: 3
#2Johannes Breitling (DKFZ: German Cancer Research Center)H-Index: 5
Last. Steffen Goerke (DKFZ: German Cancer Research Center)H-Index: 14
view all 12 authors...
PURPOSE: Dynamic glucose-enhanced (DGE)-MRI based on chemical exchange-sensitive MRI, that is, glucoCEST and gluco-chemical exchange-sensitive spin-lock (glucoCESL), is intrinsically prone to motion-induced artifacts because the final DGE contrast relies on the difference of images, which were acquired with a time gap of several mins. In this study, identification of different types of motion-induced artifacts led to the development of a 3D acquisition protocol for DGE examinations in the human ...
5 CitationsSource
#1Johannes BreitlingH-Index: 5
#2Jan Eric Meissner (DKFZ: German Cancer Research Center)H-Index: 10
Last. Steffen Goerke (DKFZ: German Cancer Research Center)H-Index: 14
view all 7 authors...
: Dual-frequency irradiation chemical exchange saturation transfer (dualCEST) allows imaging of endogenous bulk mobile proteins by selectively measuring the intramolecular spin diffusion. The resulting specificity to changes in the concentration, molecular size, and folding state of mobile proteins is of particular interest as a marker for neurodegenerative diseases and cancer. Until now, application of dualCEST in clinical trials was prevented by the inherently small signal-to-noise ratio and t...
1 CitationsSource
#1Andreas Korzowski (DKFZ: German Cancer Research Center)H-Index: 7
#2Nina Weinfurtner (DKFZ: German Cancer Research Center)H-Index: 2
Last. P Bachert (Heidelberg University)
view all 9 authors...
PURPOSE: In vivo (31) P MRSI enables noninvasive mapping of absolute pH values via the pH-dependent chemical shifts of inorganic phosphates (Pi ). A particular challenge is the quantification of extracellular Pi with low SNR in vivo. The purpose of this study was to demonstrate feasibility of assessing both intra- and extracellular pH across the whole human brain via volumetric (31) P MRSI at 7T. METHODS: 3D (31) P MRSI data sets of the brain were acquired from three healthy volunteers and three...
7 CitationsSource
#1Ferdinand Zimmermann (Heidelberg University)H-Index: 3
#2Andreas Korzowski (DKFZ: German Cancer Research Center)H-Index: 7
Last. Steffen Goerke (DKFZ: German Cancer Research Center)H-Index: 14
view all 14 authors...
PURPOSE: The application of amide proton transfer (APT) CEST MRI for diagnosis of breast cancer is of emerging interest. However, APT imaging in the human breast is affected by the ubiquitous fat signal preventing a straightforward application of existing acquisition protocols. Although the spectral region of the APT signal does not coincide with fat resonances, the fat signal leads to an incorrect normalization of the Z-spectrum, and therefore to distorted APT effects. In this study, we propose...
9 CitationsSource
#1Jan Eric Meissner (DKFZ: German Cancer Research Center)H-Index: 10
#2Andreas Korzowski (DKFZ: German Cancer Research Center)H-Index: 7
Last. Daniel Paech (DKFZ: German Cancer Research Center)H-Index: 20
view all 12 authors...
BACKGROUND: Patients with newly diagnosed inoperable glioma receive chemoradiotherapy (CRT). Standard Response Assessment in Neuro-Oncology (RANO) takes a minimum of 4 weeks after the end of treatment. PURPOSE/HYPOTHESIS: To investigate whether chemical exchange saturation transfer (CEST) MRI enables earlier assessment of response to CRT in glioma patients. STUDY TYPE: Longitudinal prospective study. POPULATION: Twelve brain tumor patients who underwent definitive CRT were included in this study...
22 CitationsSource
#1Moritz Zaiss (MPG: Max Planck Society)H-Index: 28
#2Annasofia Anemone (UNITO: University of Turin)H-Index: 6
Last. Klaus SchefflerH-Index: 76
view all 11 authors...
AIMS: To determine individual glucose hydroxyl exchange rates at physiological conditions and use this information for numerical optimization of glucoCEST/CESL preparation. To give guidelines for in vivo glucoCEST/CESL measurement parameters at clinical and ultra-high field strengths. METHODS: Five glucose solution samples at different pH values were measured at 14.1 T at various B1 power levels. Multi-B1 -Z-spectra Bloch-McConnell fits at physiological pH were further improved by the fitting of...
28 CitationsSource