Xudong Xiang
Central South University
Internal medicineMolecular biologyReceptorChemistryApoptosisImmunologyAsthmaInflammationLungCytokineCHOPPathogenesisInterleukin 17Cancer researchSignal transductionMedicinePI3K/AKT/mTOR pathwayBiologyCell biologyPharmacology
Publications 66
#1Wei Cheng (CSU: Central South University)H-Index: 2
#2Yating Peng (CSU: Central South University)H-Index: 7
Last. Xucai Liao (SYU: Shaoyang University)
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BACKGROUND: Coronavirus disease (COVID-19) is a global infectious disease with a large burden of illness and high health care costs. This study aimed to compare clinical features among adult COVID-19 patients in different age groups. METHODS: Laboratory-confirmed adult COVID-19 infection cases between December 31, 2019 to March 8, 2020 obtained from Neighboring Cities. Patients were divided into five age groups. Clinical characteristics were compared among different age groups. RESULTS: Of 299 c...
#2Yu YuanH-Index: 3
Last. Libing MaH-Index: 8
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#1Aiyuan Zhou (CSU: Central South University)H-Index: 5
#2Qing Song (CSU: Central South University)
Last. Mingyan JiangH-Index: 4
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Background null Oxygen therapy (OT) is the most widely used supportive regime in patients with hypoxemic acute respiratory failure (ARF) due to severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection. The aim of this study was to identify the effect of noninvasive ventilation support on coronavirus disease 2019 (COVID-19) patients and risk factors for invasive mechanical ventilation (IMV). null Methods null We retrospectively analyzed confirmed COVID-19 subjects from nine hospitals ...
#1Binaya Wasti (CSU: Central South University)H-Index: 3
#2Shaokun Liu (CSU: Central South University)H-Index: 8
Last. Xudong Xiang (CSU: Central South University)H-Index: 18
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#1Lei Yi (CSU: Central South University)H-Index: 2
#2Kai Ai (CSU: Central South University)H-Index: 1
Last. Dongshan Zhang (CSU: Central South University)H-Index: 10
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In this study, we investigated the role of circular RNA_30032 (circRNA_30032) in renal fibrosis and the underlying mechanisms. The study was carried out using TGF-β1-induced BUMPT cells and unilateral ureteral obstruction (UUO)-induced mice, respectively, as in vitro and in vivo models. CircRNA_30032 expression was significantly increased by 9.15- and 16.6-fold on days 3 and 7, respectively, in the renal tissues of UUO model mice. In TGF-β1-treated BUMPT cells, circRNA_30032 expression was induc...
#1Yuxin Xie (CSU: Central South University)H-Index: 1
#2Bohao Liu (CSU: Central South University)H-Index: 2
Last. Dongshan Zhang (CSU: Central South University)H-Index: 10
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Abstract Our previous study demonstrated that the Methyl-CpG–binding domain protein 2 (MBD2) mediates vancomycin (VAN)-induced acute kidney injury (AKI). However, the role and regulation of MBD2 in septic AKI is unknown. Herein, MBD2 was induced by LPS in BUMPTs and mice. For both in vitro and in vivo experiments, we showed that inhibition of MBD2 by MBD2 siRNA and MBD2-KO substantially improved the survival rate, and attenuated both LPS and CLP-induced AKI, renal cell apoptosis, and inflammator...
#1Su-bo Gong (CSU: Central South University)H-Index: 7
#2Xiao-Ying Ji (SYSU: Sun Yat-sen University)H-Index: 2
Last. Shaokun Liu (CSU: Central South University)H-Index: 8
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Background and Purpose. Allergic asthma, a respiratory disease with high morbidity and mortality, is reported to be related to the airway allergic inflammation and autophagy-induced oxidative stress. Although the therapeutic effects of fermentate prebiotic (YFP) on allergic asthma have been widely claimed, the underlying mechanism is still unclear. This study is aimed at investigating the possible mechanism for the antiasthma property of YFP in a mouse model. Methods. Ovalbumin was used to induc...
#1Zihang Zeng (CSU: Central South University)H-Index: 3
#2Yiming Ma (CSU: Central South University)H-Index: 4
Last. Yan Chen (CSU: Central South University)H-Index: 17
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This retrospective, multicenter study investigated risk factors associated with intensive care unit (ICU) admission and transfer in 461 adult patients with confirmed coronavirus disease 2019 (COVID-19) hospitalized from January 22 to March 14, 2020 in Hunan Province, China. Outcomes of ICU and non-ICU patients were compared, and a simple nomogram for predicting the probability of ICU transfer after hospital admission was developed based on initial laboratory data using a Cox proportional hazards...
#1Wenjin Sun (Sichuan University)
#2Yu Yuan (CSU: Central South University)H-Index: 3
Last. Bing Xiao (CSU: Central South University)H-Index: 5
view all 10 authors...
Asthma is a heterogeneous disease, and abnormal activation of T cells is the driving link of asthma’s pathophysiological changes. Dual-positive Th2–Th17 cells, as newly discovered T-helper cells, have the functions of Th2 and Th17 cells and can coproduce Th2 and Th17 cytokines. Previous studies have shown that dual-positive Th2–Th17 cells increase the chances of asthma and correlate with asthma severity. However, the exact role of dual-positive Th2–Th17 cells in asthma is not known. Since there ...
#1Shaokun Liu (CSU: Central South University)H-Index: 8
#2Libing Ma (GLMU: Guilin Medical University)H-Index: 8
Last. Xudong Xiang (CSU: Central South University)H-Index: 18
view all 12 authors...
Objective. Allergic asthma is a chronic inflammatory disease, which seriously affects the life quality of patients, especially children. Alanylglutamine is a nutritional supplement with potential protective and anti-inflammatory effects, but its function in allergic asthma remains elusive. In this study, we focused on the investigations of the roles and functional mechanism of Alanylglutamine in asthma. Methods. Ovalbumin (OVA) induction was utilized to establish a mouse asthma model. 16S rDNA s...
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