Erik Kaestner
University of California, San Diego
Verbal memoryNeuropsychologyDiffusion MRIPsychologyNeuroscienceCognitionCognitive psychologyElectrophysiologyPrecentral gyrusEpilepsyDiseaseDementiaElectrocorticographyTemporal lobeWhite matterTemporal cortexMemory impairmentConnectomeElectroencephalographyAudiologyMedicineFractional anisotropy
26Publications
10H-index
355Citations
Publications 28
Newest
#1Bruce P. Hermann (UW: University of Wisconsin-Madison)H-Index: 104
#2Aaron F. Struck (VA: United States Department of Veterans Affairs)H-Index: 13
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 38
view all 6 authors...
Cognitive and behavioural comorbidities are prevalent in childhood and adult epilepsies and impose a substantial human and economic burden. Over the past century, the classic approach to understanding the aetiology and course of these comorbidities has been through the prism of the medical taxonomy of epilepsy, including its causes, course, characteristics and syndromes. Although this ‘lesion model’ has long served as the organizing paradigm for the field, substantial challenges to this model ha...
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#1Erik Kaestner (UCSD: University of California, San Diego)H-Index: 10
#2Thomas Thesen (Comprehensive Epilepsy Center)H-Index: 33
Last. Eric Halgren (UCSD: University of California, San Diego)H-Index: 87
view all 6 authors...
Models of reading emphasize that visual (orthographic) processing provides input to phonological as well as lexical-semantic processing. Neurobiological models of reading have mapped these processes to distributed regions across occipital-temporal, temporal-parietal, and frontal cortices. However, the role of the precentral gyrus in these models is ambiguous. Articulatory phonemic representations in the precentral gyrus are obviously involved in reading aloud, but it is unclear if the precentral...
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#1Erik Kaestner (UCSD: University of California, San Diego)H-Index: 10
Last. Eric Halgren (UCSD: University of California, San Diego)H-Index: 87
view all 9 authors...
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#1Sanam J. Lalani (UCSF: University of California, San Francisco)H-Index: 3
#2Anny Reyes (UCSD: University of California, San Diego)H-Index: 10
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 38
view all 11 authors...
OBJECTIVE Episodic memory impairment and hippocampal pathology are hallmark features of both temporal lobe epilepsy (TLE) and amnestic mild cognitive impairment (aMCI). Pattern separation (PS), which enables the distinction between similar but unique experiences, is thought to contribute to successful encoding and retrieval of episodic memories. Impaired PS has been proposed as a potential mechanism underling episodic memory impairment in aMCI, but this association is less established in TLE. In...
1 CitationsSource
#1Erik Kaestner (UCSD: University of California, San Diego)H-Index: 10
#2Anny Reyes (UCSD: University of California, San Diego)H-Index: 10
view all 15 authors...
Epilepsy incidence and prevalence peaks in older adults yet systematic studies of brain ageing and cognition in older adults with epilepsy remain limited. Here, we characterize patterns of cortical atrophy and cognitive impairment in 73 older adults with temporal lobe epilepsy (>55 years) and compare these patterns to those observed in 70 healthy controls and 79 patients with amnestic mild cognitive impairment, the prodromal stage of Alzheimer's disease. Patients with temporal lobe epilepsy were...
2 CitationsSource
#1Anny Reyes (UCSD: University of California, San Diego)H-Index: 10
#2Erik Kaestner (UCSD: University of California, San Diego)H-Index: 10
view all 11 authors...
Objective To characterize the nature and prevalence of cognitive disorders in older adults with temporal lobe epilepsy (TLE) and compare their cognitive profiles to patients with amnestic mild cognitive impairment (ie, aMCI). Methods Seventy-one older patients with TLE, 77 aMCI, and 69 normal aging controls (NACs), all 55-80 years of age, completed neuropsychological measures of memory, language, executive function, and processing speed. An actuarial neuropsychological method designed to diagnos...
3 CitationsSource
#1Erik Kaestner (UCSD: University of California, San Diego)H-Index: 10
#2Anny Reyes (SDSU: San Diego State University)H-Index: 10
view all 9 authors...
Epilepsy incidence and prevalence peaks in older adults, yet systematic studies of brain aging and epilepsy remain limited. We investigated topological network disruption in older adults with temporal lobe epilepsy (TLE; age > 55 years). Additionally, we examined the potential network disruption overlap between TLE and amnestic mild cognitive impairment (aMCI), the prodromal stage of Alzheimer disease. Measures of network integration ("global path efficiency") and segregation ("transitivity" and...
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#1Anny Reyes (UCSD: University of California, San Diego)H-Index: 10
#2Erik Kaestner (UCSD: University of California, San Diego)H-Index: 10
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 38
view all 10 authors...
Objective: To characterize the nature and prevalence of cognitive disorders in older adults with temporal lobe epilepsy (TLE) and compare their cognitive profiles to non-epileptic patients with mild cognitive impairment (i.e., classic MCI; cMCI). Methods: Seventy-eight older patients with TLE, 77 cMCI, and 69 normal aging controls (NAC), all 55-80 years, completed neuropsychological measures of memory, language, executive function and processing speed. An actuarial neuropsychological method desi...
Source
#1Ezequiel Gleichgerrcht (MUSC: Medical University of South Carolina)H-Index: 31
#2Simon S. Keller (University of Liverpool)H-Index: 30
Last. Leonardo Bonilha (MUSC: Medical University of South Carolina)H-Index: 55
view all 13 authors...
Objective Medial temporal lobe epilepsy (TLE) is the most common form of medication-resistant focal epilepsy in adults. Despite removal of medial temporal structures, over a third of patients continue to have disabling seizures post-operatively. Seizure refractoriness implies that extra-medial regions are capable of influencing the brain network and generating seizures. We tested whether abnormalities of structural network integration could be associated with surgical outcomes. Methods Presurgic...
9 CitationsSource
#1Erik Kaestner (UCSD: University of California, San Diego)H-Index: 10
#2Adam Milton Morgan (UCSD: University of California, San Diego)H-Index: 4
Last. Eric Halgren (UCSD: University of California, San Diego)H-Index: 87
view all 9 authors...
ABSTRACTIntracranial electrophysiology (iEEG) studies using cognitive tasks contribute to the understanding of the neural basis of language. However, though iEEG is recorded continuously during clinical treatment, due to patient considerations task time is limited. To increase the usefulness of iEEG recordings for language study we provided patients with a tablet pre-loaded with media filled with natural language, wirelessly synchronised to clinical iEEG. This iEEG data collected and time-locked...
1 CitationsSource