L Bancalari
University of Pisa
AirwayInternal medicineEndocrinologyImmunologyAllergyPlaceboLung volumesAsthmaRespiratory diseaseBronchial hyperresponsivenessSputumInhalationOccupational asthmaAllergenBronchoconstrictionBronchodilatorMethacholineHypertonic salineDelayed hypersensitivityAnesthesiaChemotaxisMedicineGastroenterology
17Publications
10H-index
421Citations
Publications 17
Newest
#1L Bancalari (UniPi: University of Pisa)H-Index: 10
#2Ilaria Conti (UniPi: University of Pisa)H-Index: 5
Last. Pierluigi Paggiaro (UniPi: University of Pisa)H-Index: 55
view all 7 authors...
Background: Urinary leukotriene E4 (LTE4) excretion is a good marker of the rate of total body production of sulfidopeptide leukotrienes released during allergen challenge. Methods: Twenty-three subjects with allergic asthma were challenged with inhaled allergen, and the urinary excretion of LTE4 was determined by immunoenzymatic assay (associated with HPLC separation) at various intervals after challenge. Results: Allergen challenge caused an early airway response (EAR) with a drop in FEV1 of 4...
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#1M Taccola (UniPi: University of Pisa)H-Index: 13
#2L BancalariH-Index: 10
Last. Pier Luigi PaggiaroH-Index: 1
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: A 1-yr multicentre two-tailed randomized open study was conducted in 15 centres in Italy, with the aim of comparing the clinical efficacy (over 3 months) and tolerability (over 1 yr) of salmeterol with those of oral theophylline in patients with reversible chronic obstructive pulmonary disease (COPD). Patients with reversible COPD (forced expiratory volume in one second (FEV1) 50-80%, FEV1 after bronchodilator > 12%, n = 138) were randomized to receive salmeterol powder (50 micrograms b.i.d. w...
#1Fl Dente (UniPi: University of Pisa)H-Index: 19
#2L BancalariH-Index: 10
Last. Pierluigi PaggiaroH-Index: 55
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BACKGROUND—The long acting β2 agonist salmeterol is very effective in preventing asthmatic responses to specific stimuli, and this effect could theoretically be due to some anti-inflammatory property in addition to bronchodilator property. METHODS—The protective effect of a single dose of salmeterol (50 µg) on allergen induced early and late responses and on the associated airway inflammation was investigated in a double blind, placebo controlled, crossover study in 11 atopic asthmatic subjects....
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#1D GianniniH-Index: 22
#2Pierluigi PaggiaroH-Index: 55
Last. Carlo GiuntiniH-Index: 46
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To evaluate the sensitivity of peak expiratory flow (PEF), obtained by portable peak flow meter, in detecting mild changes in airway caliber as assessed by forced expiratory volume in 1 sec (FEV1), we studied 184 subjects who underwent different bronchial challenge tests for suspected bronchial asthma. We measured FEV1 and PEF during bronchoconstriction induced by different stimuli: allergen, methacholine, toluene diisocyanate vapors, exercise, or distilled water inhalation; a total of 186 tests...
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#1Fl Dente (UniPi: University of Pisa)H-Index: 19
#2S Carnevali (UniPi: University of Pisa)H-Index: 18
Last. Carlo Giuntini (UniPi: University of Pisa)H-Index: 46
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In order to evaluate the relationship between allergen-induced heat-stable neutrophil chemotactic activity (HS-NCA) release during early asthmatic reaction (EAR) and the presence of a late asthmatic r
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#1L BancalariH-Index: 10
#2Fl DenteH-Index: 19
Last. Pierluigi PaggiaroH-Index: 55
view all 12 authors...
We evaluated the relationship between blood markers of mast-cell (plasma histamine and serum level of heat-stable neutrophil chemotactic activity [NCA]) and eosinophil (serum eosinophil cationic protein [ECP]) activation during early airway response (EAR) and late airway response (LAR) to allergen inhalation in 24 asthmatic subjects. After EAR, 14 subjects showed significant LAR (FEV1 fall: 25%), while 10 subjects showed equivocal LAR (FEV1 fall: 15–20%). A significant increase from baseline val...
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#1Elena Bacci (UniPi: University of Pisa)H-Index: 27
#2Silvana Cianchetti (UniPi: University of Pisa)H-Index: 23
Last. Carlo Giuntini (UniPi: University of Pisa)H-Index: 46
view all 10 authors...
Summary Background Hypertonic saline-indueed sputum has recently been used for the evaluation of airway inflammation in asthma. Objective To assess the effect of hypertonicity on airway inflammation. Methods We compared the inflammatory cell composition of hypertonic saline-induced sputum with that of isotonic saline-induced sputum in 21 asthmatic subjects and, at baseline and 30min after each sputum induction, we measured bronchial hyper-responsiveness to methacholine as an indirect marker to d...
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: Leukotrienes have been demonstrated to play an important role as mediators of many pathophysiologic alterations of asthma. Pharmaceutical companies have thus promode many efforts to synthesize new drugs with inhibitory activity on 5-lypoxygenase or with functional antagonism on cystenyl leukotriene receptors. Several compounds have been studied in humans, and some of them should soon be on the market. One of these compounds, ICI 204,219 ("accolate"), a receptor antagonist active by the oral ro...
The aim of this study was to assess the effects of short-term exposure to low levels of nitrogen dioxide (NO2) on airway inflammation. We studied seven normal, eight mild asthmatic and seven chronic obstructive pulmonary disease (COPD) subjects. All subjects were exposed to air or to 0.3 parts per million (ppm) NO2 for 1 h, with moderate intermittent exercise, on different days and in random order. Before and 2 h after exposure, symptom score and results of pulmonary function tests (PFTs) were a...
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In 21 asthmatic subjects, several functions of isolated peripheral neutrophils (chemokinesis and chemotaxis toward 10% E. coli; superoxide anion generation after PMA; leukotriene B4 (LTB4) release from whole blood and isolated neutrophtls, before and after different stimuli) were evaluated during an acute exacerbation of asthma, and after 14 – 54 days of treatment with systemic glucocorticosteroids (GCS). During acute exacerbation, superoxide anion generation was higher in asthmatics than in ele...
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