Kazuo Kubota
Tohoku University
CancerRadiologyPET-CTEndocrinologyPathologyTomographyChemistryPositronIn vivoPositron emission tomographyLung cancerFluorodeoxyglucoseLungDifferential diagnosisMethionineNuclear medicineCancer researchRadiation therapyBiochemistryMedicine
Publications 386
#1Kazuo KubotaH-Index: 43
#2Noriko TanakaH-Index: 5
Last. Masao Kobayakawa (Fukushima Medical University)H-Index: 1
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Objective The aim of this multicenter prospective study was to compare the sensitivity of 18F-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) with that of 67Ga single photon emission computed tomography (SPECT) for the identification of the site of greatest importance for the final diagnosis of the cause of fever of unknown origin (FUO). Methods The study participants consisted of patients with an axillary temperature ≥ 38.0 °C on ≥ 2 occasions within 1 week, w...
#1Motoyuki Takaki (Fukushima Medical University)H-Index: 2
#2Nobuyuki Takenaka (Fukushima Medical University)H-Index: 2
Last. Takashi Matsushita (Fukushima Medical University)H-Index: 21
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ABSTRACT Objective There are currently no robust methods for accurately localizing the infection focus of osteomyelitis. Accumulation of fluorodeoxyglucose (FDG) is nonspecific, and it is well-known that it can indicate inflammatory cells and sites of inflammation, and its effectiveness in detecting osteomyelitis has been reported recently. However, the optimal cut-off value for the Standardized Uptake Value (SUV) in detecting the focus of osteomyelitis through 18F-FDG-PET/CT is not known. We in...
#1Kazuo KubotaH-Index: 43
#2Motoki Takeuchi (Fujita Health University)H-Index: 2
Last. Yuji Nakamoto (Kyoto University)H-Index: 47
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Fever of unknown origin (FUO) is a syndrome of fever without obvious cause, and it is regarded as a difficult diagnostic challenge. Inflammation of unknown origin (IUO) is similar to FUO, except that it is not associated with elevated body temperature. FDG-PET/CT may cover the diagnosis of a wide spectrum of diseases causing FUO/IUO, namely tumors and inflammation, under the conditions that the disease is active (consuming a lot of glucose), and the lesion is focal and of a size that is sufficie...
#1Junichi Tsuchiya (Tokyo Medical and Dental University)H-Index: 2
#2Ukihide Tateishi (Tokyo Medical and Dental University)H-Index: 40
Last. Kazuo KubotaH-Index: 1
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Patients with large-vessel vasculitis (LVV) may present with nonspecific clinical symptoms and increased inflammatory markers, including C-reactive protein and erythrocyte sedimentation rate. Due to these nonspecific characteristics, routine diagnostic tests may be inconclusive for such patients. FDG-PET/CT is a functional imaging modality that can be a useful tool for diagnosis in inflammatory diseases, as well as in oncology assessments. Functional FDG-PET, when combined with anatomical CT, ma...
#1Toru Awaya (Toho University)H-Index: 3
#2Ryogo MinamimotoH-Index: 2
Last. Masao Moroi (Toho University)H-Index: 23
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#1Kazuya Koyama (Tokyo Metropolitan University)H-Index: 1
#2Takuya MitsumotoH-Index: 6
Last. Masahiro Fukushi (Tokyo Metropolitan University)H-Index: 12
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We aimed to determine the difference in tumor volume associated with the reconstruction model in positron-emission tomography (PET). To reduce the influence of the reconstruction model, we suggested a method to measure the tumor volume using the relative threshold method with a fixed threshold based on peak standardized uptake value (SUVpeak). The efficacy of our method was verified using 18F-2-fluoro-2-deoxy-d-glucose PET/computed tomography images of 20 patients with lung cancer. The tumor vol...
1 CitationsSource
#1Kazuo KubotaH-Index: 43
#2Hiroyuki YamashitaH-Index: 31
Last. Akio MimoriH-Index: 27
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FDG is a tracer for visualizing glucose metabolism. PET/CT using FDG is widely used for the diagnosis of cancer, because glycolysis is elevated in cancer cells. Similarly, active inflammatory tissue also exhibits elevated glucose metabolism because of glycolysis in activated macrophages and proliferating fibroblasts. Elevated FDG uptake by active inflammatory tissues, such as those affected by arthritis, vasculitis, lymphadenitis, and chondritis, has enabled the diagnosis of inflammatory disease...
30 CitationsSource
#1Toshihiko Wakabayashi (Nagoya University)H-Index: 41
#2Toshihiko IuchiH-Index: 18
Last. Kan KubomuraH-Index: 1
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Objective(s): The study objective was to assess the diagnostic performance of positron emission tomography (PET) for gliomas using the novel tracer 18F-fluciclovine (anti-18FFACBC) and to evaluate the safety of this tracer in patients with clinically suspected gliomas.Methods: Anti-18FFACBC was administered to 40 patients with clinically suspected high- or low-grade gliomas, followed by PET imaging. T1-weighted, contrast-enhanced T1-weighted, and fluid-attenuated inversion recovery (or T2-weight...
15 CitationsSource
Recently, the co-occurrence of myelodysplastic syndrome (MDS) and Behcet's disease (BD) has been reported in association with trisomy 8 and HLA 51, with the pathology varying from vasculitis to acute neutrophilic inflammation. We report for the first time about imaging findings of F-fluorodeoxyglucose (FDG) positron emission/computed tomography (PET/CT) in 2 cases having MDS accompanied by BD. In these cases, 18 F-FDG PET/CT images clearly revealed high uptake by bone marrow in MDS and by genita...
3 CitationsSource
#1Tetsuro TsujimotoH-Index: 15
#2Takehiro SugiyamaH-Index: 12
Last. Mitsuhiko NodaH-Index: 49
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: Glycemic control alone does not reduce cardiovascular events in patients with type 2 diabetes (T2D), and routine screening of all T2D patients for asymptomatic coronary artery disease (CAD) is not effective for preventing acute cardiac events. We examined the effectiveness of an aggressive screening protocol for asymptomatic CAD in T2D patients with advanced vascular complications.We designed a 3-year cohort study investigating the effectiveness of the aggressive coronary screening for T2D pat...
3 CitationsSource