Arunakaran Jagadeesan
University of Madras
Colloidal goldOffspringCancerInternal medicineEndocrinologyCYP17A1OncologyGene expressionCytotoxic T cellAlkaline phosphataseAndrologyNanotechnologyDNMT1Poly ADP ribose polymeraseChemistryApoptosisDNA methylationMaterials scienceIn uteroHormone receptorBlood–testis barrierSuperoxide dismutaseOccludinOxidative stressAromataseLactationAndrogen-binding proteinDAPIAnogenital distanceLeydig cellAntioxidantCorn oilGlutathione peroxidaseDNA methyltransferaseProstate cancerOvarian cancerLipid peroxidationEndocrine disruptorPhthalateSertoli cellQuercetinPopulationCytochrome cCell cycleProgrammed cell deathMethylationAryl hydrocarbon receptorEpigeneticsDNA fragmentationReactive oxygen speciesCancer researchClaudinViability assayGlutathioneTestosteroneBiochemistryAndrogen receptorCell growthHistoneFas ligandBone resorptionProtein kinase BCholesterol side-chain cleavage enzymeOvariectomized ratEstrogen receptorTranscription factorBiologyMethyltransferasePharmacology
10Publications
6H-index
373Citations
Publications 10
Newest
#1Sathish Kumar Thangavelu (University of Madras)H-Index: 1
#2Manju Mohan (University of Madras)H-Index: 1
Last. Arunakaran Jagadeesan (University of Madras)H-Index: 6
view all 4 authors...
The present study was designed to establish the epigenetic mechanisms by which lactational exposure to PCBs affects the Leydig cell function in progeny rats. The lactating dams were oral gavaged with different doses of PCBs [1, 2 and 5 mg/kg or corn oil ] and Leydig cells were isolated from the testes of progeny rats at postnatal day (PND) 60. We assessed the expression of transcription factors regulating steroidogenic machinery and the promoter methylation of LHR and AR in the Leydig cells. Our...
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#1Dhanaraj Teekaraman (University of Madras)H-Index: 2
#2Sugantha Priya Elayapillai (University of Madras)H-Index: 2
Last. Arunakaran Jagadeesan (University of Madras)H-Index: 6
view all 4 authors...
Abstract Ovarian cancer is the leading cause of gynaecology related cancer death worldwide. It is often diagnosed with an advanced stage. Apoptosis is a process of programmed cell death controlled by cell cycle machinery and several signaling pathways. Plant-derived compounds have received an increased interest in the treatment of cancer. Quercetin is a flavonoid present in fruits and vegetables which possess anticancer properties. Several studies have been demonstrated that quercetin induces ap...
20 CitationsSource
#1Sathish Kumar Thangavelu (University of Madras)H-Index: 1
#2Sugantha Priya Elaiyapillai (University of Madras)H-Index: 1
Last. Arunakaran Jagadeesan (University of Madras)H-Index: 6
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Abstract The present study was aimed to determine the effects of lactational exposure of PCBs (Aroclor 1254) on Leydig cellular steroidogenesis in F 1 progeny rats. Lactating dams were orally treated by gavage with different doses of PCBs (1, 2 and 5 mg/kg b.wt./day). Male progenies were sacrificed on PND60. Our results demonstrated that exposure to PCBs decreased the body weight, testis weight and anogenital distance (AGD) index in the F 1 progeny rats. Importantly, PCBs exposure reduced the se...
4 CitationsSource
#1Sugantha Priya Elayapillai (University of Madras)H-Index: 2
#2Dhanaraj Teekaraman (University of Madras)H-Index: 2
Last. Arunakaran Jagadeesan (University of Madras)H-Index: 6
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Abstract The study was conducted to investigate the protective role of α-tocopherol against polychlorinated biphenyls (PCBs) induced effect in Sertoli cell function of F 1 prepuberal rats. Dams were grouped into six; each group consists of six animals. Group 1–control treated with corn oil as vehicle, group II- 0.5 mgPCBs/kg bw/day, group III- 0.5mgPCBs/kg bw/day with α-tocopherol (50 mg α-tocopherol/kg bw/day), group IV- 1mgPCBs/kg bwt/day, group V- 1mgPCBs/kg bw/day with α-tocopherol (50 mg α-...
4 CitationsSource
#1S. Balakrishnan (University of Madras)H-Index: 8
#2Firdous Ahmad Bhat (University of Madras)H-Index: 8
Last. Arunakaran Jagadeesan (University of Madras)H-Index: 6
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7 CitationsSource
Phthalates are the largest group of environmental pollutants and are considered toxicant to the endocrine system. The present study was aimed to test the effect of in utero exposure of di(2-ethylhexyl)phthalate (DEHP) on Leydig cell steroidogenesis in F1 male offspring's. Pregnant dams were oral gavaged with different doses (1, 10, and 100 mg/kg/day) of DEHP or olive oil during gestational Day 9–21. Serum testosterone (T) and estradiol (E2) levels were significantly reduced in male offspring at ...
43 CitationsSource
#1S Sekaran (University of Madras)H-Index: 1
#2P Balaganapathy (University of Madras)H-Index: 1
Last. Arunakaran Jagadeesan (University of Madras)H-Index: 6
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Di(2-ethylhexyl) phthalate (DEHP) is a ubiquitous environmental contaminant and a well-known endocrine disruptor (ED) that interferes with the reproductive function in both humans and animals. This study aimed to find out the impact of lactational exposure of DEHP in testes of first filial generation (F1) progeny male rat postnatal day (PND)-60. Lactating dams were orally treated with DEHP (0, 1, 10 and 100 mg/kg body weight/day, respectively) from the PND-1 to PND-21. Rats were killed at PND 60...
17 CitationsSource
#1Suganya Sekaran (University of Madras)H-Index: 2
#2Selvakumar Kandaswamy (University of Madras)H-Index: 1
Last. Arunakaran Jagadeesan (University of Madras)H-Index: 6
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The present study aims to investigate the protective effect of quercetin against Aroclor-1254–induced hepatotoxicity in rats. Male Wistar rats were grouped into Group I control received vehicle (corn oil; 1 mL/kg bwt); Group II quercetin alone (50 mg/kg bwt/day orally); Group III Aroclor-1254 (2 mg/kg bwt/day intraperitoneally); Group IV Aroclor-1254 + quercetin treated for 30 days. The Aroclor-1254 treatment caused significant alteration in the biochemical parameters (hydrogen peroxide, lipid p...
22 CitationsSource
#1Kavitha Venkatesh (University of Madras)H-Index: 1
#2Sharmila Govindaraj (University of Madras)H-Index: 1
Last. Arunakaran JagadeesanH-Index: 6
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: Prostate cancer is the most common malignancy and the second leading cause of cancer death in the male population in developing countries. Ukrain is a reaction product of different alkaloids from Chelidoniummajus L. (celandine) conjugated with thiophosphoric acid, which has cytotoxic effects on various malignant cells. In the present study, cell viability was assessed using the dimethyl thiazolyl tetrazolium bromide (MTT)method in PC-3 cells after treatment with Ukrain. The IC(50) value was ob...
6 CitationsSource
#1Sridhar Muthusami (University of Madras)H-Index: 9
#2Ilangovan Ramachandran (University of Madras)H-Index: 11
Last. Srinivasan Narasimhan (University of Madras)H-Index: 3
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Abstract Background There is increasing evidence suggesting the role of free radicals in bone resorption and bone loss. Ovariectomized rats have been used as the animal model for the study of osteoporosis. Oxidative stress due to reactive oxygen species (ROS) can cause oxidative damage to cells. Cells have a number of defense mechanisms to protect themselves from the toxicity of ROS. Even though, there are studies portraying the role of free radicals in bone loss, the defense mechanism adapted b...
252 CitationsSource