Mohamad Alaa Terkawi
Hokkaido University
AntigenMolecular biologyNested polymerase chain reactionVirologyAntibodyComplementary DNAImmunologyIn vivoWestern blotBabesia bovisToxoplasma gondiiBabesiosisBabesiaBabesia bigeminaRecombinant DNAVeterinary medicineSerologyMedicineBiologyMicrobiologyAntiserumCell biology
77Publications
19H-index
888Citations
Publications 79
Newest
#1Shunichi Yokota (Hokkaido University)H-Index: 1
#2Gen Matsumae (Hokkaido University)H-Index: 2
Last. Masahiko Takahata (Hokkaido University)H-Index: 30
view all 13 authors...
Abstract null null A growing body of evidence suggests that immune factors that regulate osteoclast differentiation and bone resorption might be promising therapeutic agents for the treatment of osteoporosis. The expression of CLCF1, an immune cell-derived molecule, has been reported to be reduced in patients with postmenopausal osteoporosis. This suggests that it may be involved in bone remodeling. Thus, we explored the functional role of CLCF1 in osteoclastogenesis and bone loss associated wit...
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#1Hotaka Ishizu (Hokkaido University)H-Index: 1
#2Kosuke Arita (Hokkaido University)
Last. Norimasa Iwasaki (Hokkaido University)H-Index: 45
view all 5 authors...
Introduction: Osteoporosis is characterized by the fragility of bones, leading to fractures and, consequently, the deterioration of functional capacity and quality of life. Postmenopausal women, in particular, are prone to osteoporosis and often require anti-osteoporosis treatment. In the last few decades, various anti-osteoporosis drugs have been approved for clinical use. In an aging society, osteoporosis cannot be treated using a single agent; therefore, switching therapy is an important trea...
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#1Masanari Hamasaki (Hokkaido University)H-Index: 4
#2Mohamad Alaa Terkawi (Hokkaido University)H-Index: 19
Last. Norimasa Iwasaki (Hokkaido University)H-Index: 45
view all 5 authors...
ObjectiveOsteoarthritis is a progressive joint disease characterized by cartilage degradation and synovial inflammation. Presence of cartilage fragments in the joint due to degradation of cartilage...
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#1Gen Matsumae (Hokkaido University)H-Index: 2
#2Tomohiro Shimizu (Hokkaido University)H-Index: 11
Last. Norimasa Iwasaki (Hokkaido University)H-Index: 45
view all 10 authors...
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#1Taku EbataH-Index: 2
Last. Norimasa IwasakiH-Index: 45
view all 13 authors...
Summary null Synovial macrophages that are activated by cartilage fragments initiate synovitis, a condition that promotes hypertrophic changes in chondrocytes leading to cartilage degeneration in OA. In this study, we analyzed the molecular response of chondrocytes under condition of this type of stimulation to identify a molecular therapeutic target. Stimulated macrophages promoted hypertrophic changes in chondrocytes resulting in production of matrix-degrading enzymes of cartilage. Among the t...
Source
#1Gen MatsumaeH-Index: 2
#2Tomohiro ShimizuH-Index: 11
Last. Norimasa IwasakiH-Index: 45
view all 10 authors...
Source
#1Gen Matsumae (Hokkaido University)H-Index: 2
#2Tomohiro Shimizu (Hokkaido University)H-Index: 11
Last. Norimasa Iwasaki (Hokkaido University)H-Index: 45
view all 10 authors...
Background: Macrophage-derived factors are generally thought to play a key role in the pathogenesis of aseptic loosening though initiating periprosthetic inflammation and pathological bone resorption. Therefore, the aim of this study was to identify macrophage-derived factors that promote osteoclast differentiation and periprosthetic bone destruction. Methods: We examined the effects of 12 macrophage-derived factors that were identified by RNA sequencing analysis of stimulated macrophages on ost...
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#1Daisuke Takahashi (Hokkaido University)H-Index: 11
#2Yoshihiro NoyamaH-Index: 1
Last. Norimasa Iwasaki (Hokkaido University)H-Index: 45
view all 7 authors...
BACKGROUND Internal fixation is recommended for treating Vancouver B1 periprosthetic femoral fractures. Although several fixation procedures have been developed with high fixation stability and union rates, long-term weight-bearing constructs are still lacking. Therefore, the aim of the present study was to evaluate the stability of a double-plate procedure using reversed contralateral locking compression-distal femoral plates for fixation of Vancouver B1 periprosthetic femoral fractures under f...
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#1Yuan Tian (Hokkaido University)H-Index: 2
#2Tomohiro Onodera (Hokkaido University)H-Index: 17
Last. Norimasa IwasakiH-Index: 45
view all 8 authors...
Systemic injection of a nerve growth factor (NGF) antibody has been proven to have a significant relevance in relieving osteoarthritis (OA) pain, while its adverse effects remain a safety concern for patients. A local low-dose injection is thought to minimize adverse effects. In this study, OA was induced in an 8-week-old male Sprague–Dawley (SD) rat joint by monoiodoacetate (MIA) injection for 2 weeks, and the effect of weekly injections of low-dose (1, 10, and 100 µg) NGF antibody or saline (c...
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#1Yuan Tian (Hokkaido University)H-Index: 2
#2Mohamad Alaa Terkawi (Hokkaido University)H-Index: 19
Last. Norimasa Iwasaki (Hokkaido University)H-Index: 45
view all 14 authors...
Periprosthetic osteolysis induced by orthopedic implant-wear particles continues to be the leading cause of arthroplasty failure in majority of patients. Release of the wear debris results in a chronic local inflammatory response typified by the recruitment of immune cells, including macrophages. The cellular mediators derived from activated macrophages favor the osteoclast-bone resorbing activity resulting in bone loss at the site of implant and loosening of the prosthetic components. Emerging ...
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