K. Wiltshire
Peter MacCallum Cancer Centre
CancerInternal medicineRadiologyUrologySurgeryOncologyRandomized controlled trialFiducial markerMedical physicsProstateAdjuvantProstatectomyProstate cancerSalvage therapyRectumProstate-specific antigenNuclear medicinePost prostatectomy radiotherapyRadiation therapyColorectal cancerClinical trialGeneral surgeryMedicine
Publications 38
#1Belinda A. Campbell (Peter MacCallum Cancer Centre)H-Index: 16
#2A. Lasocki (Peter MacCallum Cancer Centre)
Last. Greg Wheeler (Peter MacCallum Cancer Centre)H-Index: 14
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Abstract Aims Radiation-induced cavernomas (RIC) are common late toxicities in long-term survivors of malignancy following cerebral irradiation. However, the natural history of RIC is poorly described. We report the first series of long-term surveillance of RIC using modern magnetic resonance imaging (MRI) including highly sensitive susceptibility-weighted imaging (SWI). The aims of this research were to better characterise the natural history of RIC and investigate the utility of MRI-SWI for sc...
#1Andrew Kneebone (USYD: University of Sydney)H-Index: 29
Last. Maria PearseH-Index: 9
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Summary Background Adjuvant radiotherapy has been shown to halve the risk of biochemical progression for patients with high-risk disease after radical prostatectomy. Early salvage radiotherapy could result in similar biochemical control with lower treatment toxicity. We aimed to compare biochemical progression between patients given adjuvant radiotherapy and those given salvage radiotherapy. Methods We did a phase 3, randomised, controlled, non-inferiority trial across 32 oncology centres in Aus...
48 CitationsSource
#1Laura Murphy (Westmead Hospital)
#2Jessica Cantwell (Westmead Hospital)
Last. Verity Ahern (USYD: University of Sydney)H-Index: 11
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INTRODUCTION Around 300 children in Australia and New Zealand (ANZ) undergo a course of radiation treatment (RT) each year. A fortnightly videoconference for radiation oncologists managing children started in 2013. We conducted an audit of the videoconference to assess its influence on the care of children who receive RT in ANZ. METHODS De-identified data from minutes (August 2013-December 2019) were analysed retrospectively using three categories: meeting participation, case presentations and m...
29 CitationsSource
#1K. Cloak (UNSW: University of New South Wales)H-Index: 3
#2Michael G Jameson (UNSW: University of New South Wales)H-Index: 9
Last. Annette Haworth (USYD: University of Sydney)H-Index: 23
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INTRODUCTION: Variation in target volume delineation from clinical trial protocols has been shown to contribute to poorer patient outcomes. A clinical trial quality assurance framework can support compliance with trial protocol. Results of the TROG 08.03 RAVES benchmarking exercise considering variation from protocol, inter-observer variability and impact on dosimetry are reported in this paper. METHODS: Clinicians were required to contour and plan a benchmarking case according to trial protocol...
4 CitationsSource
#1Hester Lieng (Gosford Hospital)H-Index: 1
#2Amy Hayden (Westmead Hospital)H-Index: 6
Last. Andrew KneeboneH-Index: 29
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The management of patients with biochemical, local, nodal, or oligometastatic relapsed prostate cancer has become more challenging and controversial. Novel imaging modalities designed to detect recurrence are increasingly used, particularly PSMA-PET scans in Australia, New Zealand and some European countries. Imaging techniques such as MRI and PET scans using other prostate cancer-specific tracers are also being utilised across the world. The optimal timing for commencing salvage treatment, and ...
28 CitationsSource
Purpose To explore site- and clinician-level factors associated with protocol violations requiring real-time-review (RTR) resubmission in a multicenter clinical trial to help tailor future quality assurance (QA) protocols. Methods and Materials RAVES (Radiation Therapy–Adjuvant vs Early Salvage) (Trans-Tasman Radiation Oncology Group 08.03) is a randomized trial comparing adjuvant with early salvage radiation therapy in men with positive surgical margins or pT3 disease after prostatectomy. Quali...
7 CitationsSource
#1Yuvnik TradaH-Index: 2
Last. Jarad MartinH-Index: 26
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#1Maria Pearse (Auckland City Hospital)H-Index: 9
#2Carol Fraser-Browne (Auckland City Hospital)H-Index: 7
Last. Andrew KneeboneH-Index: 29
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Objectives To test the hypothesis that observation with early salvage radiotherapy (SRT) is not inferior to ‘standard’ treatment with adjuvant RT (ART) with respect to biochemical failure in patients with pT3 disease and/or positive surgical margins (SMs) after radical prostatectomy (RP). To compare the following secondary endpoints between the two arms: patient-reported outcomes, adverse events, biochemical failure-free survival, overall survival, disease-specific survival, time to distant fail...
91 CitationsSource
#1Andrew KneeboneH-Index: 29
Last. Maria PearseH-Index: 9
view all 20 authors...