Mitra Shojania Feizabadi
Seton Hall University
PhysicsCancerBiophysicsProcessivityCellSystems biologyMolecular motorChemistryMaterials scienceIn vitroMicrotubuleTau proteinPopulationCell kineticsNormal cellTotal cellTumor cellsMathematicsPolymerizationKinesinMicrotubule-associated proteinTubulinBiologyCell biologyPersistence length
Publications 39
#1Mitra Shojania Feizabadi (Seton Hall University)H-Index: 6
#2Ramiz S. Alejilat (Seton Hall University)
Last. Ibukunoluwa I. Akintola (Seton Hall University)H-Index: 1
view all 5 authors...
Molecular motors are microtubule-based proteins which contribute to many cell functions, such as intracellular transportation and cell division. The details of the nature of the mutual interactions between motors and microtubules still needs to be extensively explored. However, electrostatic interaction is known as one of the key factors making motor-microtubule association possible. The association rate of molecular motors to microtubules is a way to observe and evaluate the charge of the bio-m...
#1Mitra Shojania Feizabadi (Seton Hall University)H-Index: 6
#2Marcos A.V. Hernandez (Seton Hall University)H-Index: 2
Last. Ibukunoluwa I. Akintola (Seton Hall University)H-Index: 1
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Abstract Growing evidence continues to point toward the critical role of beta tubulin isotypes in regulating some intracellular functions. Changes that were observed in the microtubules’ intrinsic dynamics, the way they interact with some chemotherapeutic agents, or differences on translocation specifications of some molecular motors along microtubules, were associated to their structural uniqueness in terms of beta tubulin isotype distributions. These findings suggest that the effects of microt...
2 CitationsSource
#1Mitra Shojania Feizabadi (Seton Hall University)H-Index: 6
#2Brandon Rosario (Seton Hall University)H-Index: 2
Last. Marcos A.V. Hernandez (Seton Hall University)H-Index: 2
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Abstract Recent studies suggested a link between diversity of beta tubulin isotypes in microtubule structures and the regulatory roles that they play not only on microtubules' intrinsic dynamic, but also on the translocation characteristics of some of the molecular motors along microtubules. Remarkably, unlike porcine brain microtubules, MCF7 microtubules are structured from a different beta tubulin distribution. These types of cancer microtubules show a relatively stable and slow dynamic. In ad...
3 CitationsSource
Background Drug-induced resistance is one the major obstacles that may lead to therapeutic failure during cancer treatment. Different genetic alterations occur when tumor cells divide. Among new generations of tumor cells, some may express intrinsic resistance to a specific chemotherapeutic agent. Also, some tumor cells may carry a gene that can develop resistance induced by the therapeutic drug. The methods by which the therapeutic approaches need to be revised in the occurrence of drug induced...
11 CitationsSource