Aldo Scarpa
University of Verona
GeneCancerInternal medicinePathologyOncologyMolecular biologyImmunologyImmunohistochemistryPancreatic diseaseCarcinomaPancreasNeuroendocrine tumorsPancreatic cancerAdenocarcinomaKRASCancer researchCarcinogenesisMedicineBiologyGastroenterology
Publications 746
#1Massimiliano Tuveri (University of Verona)H-Index: 17
#2Eleonora Milani (University of Milan)
Last. Claudio Bassi (University of Verona)H-Index: 110
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BACKGROUND We designed a retrospective computational study to evaluate the effects of hemodynamics on portal confluence remodeling in real models of patients with malignancies of the pancreatic head. METHODS Patient-specific models were created according to computed tomography data. Fluid dynamics was simulated by using finite-element methods. Computational results were compared to morphological findings. RESULTS Five patients underwent total pancreatectomy, one had duodenopancreatectomy. Vein r...
#1Raffaella Casolino (Glas.: University of Glasgow)H-Index: 2
#2Andrew V. Biankin (Glas.: University of Glasgow)H-Index: 73
Last. David K. Chang (Glasgow Royal Infirmary)H-Index: 48
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#1Antonio Marchetti (University of Chieti-Pescara)H-Index: 23
#2Mattia BarbareschiH-Index: 60
Last. Giancarlo PruneriH-Index: 76
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Next Generation Sequencing (NGS) is increasingly used in diagnostic centers for the assessment of genomic alterations to select patients for precision oncology. The Italian Society of Anatomic Pathology and Diagnostic Cytopathology (SIAPEC) through the Molecular Pathology and Predictive Medicine Study Group (PMMP) has been following the progressive development of centers that have adopted NGS technology in diagnostics over time. In July 2017, a study network on massive parallel sequencing was ac...
#1Claudio LuchiniH-Index: 31
#2Rita T. LawlorH-Index: 31
Last. Aldo ScarpaH-Index: 99
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PURPOSE OF REVIEW Alternative lengthening of telomeres (ALT) is a telomerase-independent mechanism used by some types of malignancies, including pancreatic neuroendocrine tumors, to overcome the issue of telomere shortening, thus supporting tumor growth and cell proliferation. This review is focused on the most important achievements and opportunities deriving from ALT assessment in PanNET onco-pathology, highlighting the most promising fields in which such biomarker could be implemented in clin...
#1Stephan DreyerH-Index: 11
Last. Anubhav MittalH-Index: 23
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Background: The long-term outcomes following surgical resection for pancreatic ductal adenocarcinoma (PDAC) remains poor, with only 20% of patients surviving 5 years after pancreatectomy. Patient selection for surgery remains sub-optimal largely due to the absence of consideration of aggressive tumor biology. Objective: The aim of this study was to evaluate traditional staging criteria for PDAC in the setting of molecular subtypes. Methods: Clinicopathological data were obtained for 5 independen...
#1Raffaella Casolino (Glas.: University of Glasgow)H-Index: 2
#2Salvatore PaiellaH-Index: 23
Last. Fieke E.M. Froeling (Glas.: University of Glasgow)H-Index: 15
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PURPOSETo analyze the prevalence of homologous recombination deficiency (HRD) in patients with pancreatic ductal adenocarcinoma (PDAC).MATERIALS AND METHODSWe conducted a systematic review and meta...
#1Michelle R. Goulart (QMUL: Queen Mary University of London)H-Index: 6
#2Jennifer Watt (QMUL: Queen Mary University of London)H-Index: 5
Last. Catrin Cox (Cardiff University)H-Index: 1
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Pancreatic ductal adenocarcinoma (PDAC), characterized by dense desmoplastic stroma laid down by pancreatic stellate cells (PSC), has no reliable diagnostic biomarkers for timely detection. A multi-center cohort of PDAC patients and controls (chronic pancreatitis, intra-ductal papillary neoplasms, gallstones and otherwise healthy) donated serum in an ethically approved manner. Serum PTX3 above 4.34 ng/mL has a higher sensitivity (86%, 95% confidence interval (CI): 65-97%) and specificity (86%, 9...
#1Serena Ammendola (University of Verona)H-Index: 3
#2Nicolò Caldonazzi (University of Brescia)
Last. Aldo Scarpa (University of Verona)H-Index: 99
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Oligodendroglioma is defined by IDH mutation and 1p/19q codeletion. The latter is mutually exclusive to ATRX immunohistochemical loss and has been recently associated with the loss of H3K27me3 immunostaining. We aimed to assess the diagnostic and prognostic value of H3K27me3 immuno-expression in diffuse gliomas with oligodendroglial or mixed oligoastrocytic morphology. H3K27me3 immunostaining was performed in 69 diffuse gliomas with oligodendroglial (n = 62) or oligoastrocytic (n = 7) morphology...
#1Rita T. LawlorH-Index: 31
#2Paola MattioloH-Index: 3
Last. Roberto SalviaH-Index: 52
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Tumor mutational burden (TMB) is a numeric index that expresses the number of mutations per megabase (muts/Mb) harbored by tumor cells in a neoplasm. TMB can be determined using different approaches based on next-generation sequencing. In the case of high values, it indicates a potential response to immunotherapy. In this systematic review, we assessed the potential predictive role of high-TMB in pancreatic ductal adenocarcinoma (PDAC), as well as the histo-molecular features of high-TMB PDAC. H...
#2Roberto Di MitriH-Index: 11
Last. Gloria Fernández-Esparrach (University of Barcelona)H-Index: 33
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ABSTRACT null null Background and aims null Benefit of rapid on-site evaluation (ROSE) on diagnostic accuracy of endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) has never been evaluated in a randomized study. This trial aimed to test the hypothesis that in solid pancreatic lesions (SPLs), diagnostic accuracy of EUS-FNB without ROSE was not inferior to that of EUS-FNB with ROSE. null null null Methods null Non-inferiority study (non-inferiority margin 5%) conducted at 14 centers in eigh...
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