Nabil A. Alhakamy
King Abdulaziz University
CytotoxicityPharmacokineticsBiophysicsGene deliveryCellCytotoxic T cellBioavailabilityChemistryApoptosisIn vivoChitosanDrug deliveryDrugChromatographyCancer researchTransfectionMedicineNasal administrationZeta potentialPharmacology
108Publications
12H-index
521Citations
Publications 105
Newest
#1Sima Singh (Chandigarh University)
#1Sima Singh (Chandigarh University)H-Index: 11
Last. Prashant Kesharwani (Jamia Hamdard)H-Index: 38
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Triple-negative breast cancers (TNBCs) form a heterogeneous group of breast carcinomas that lack expression of estrogen receptor, progesterone receptor and epidermal growth factor receptor 2. In the past decade, immune checkpoint inhibitors (ICIs) have revolutionized the arena of cancer immunotherapy. Early results are now accumulating from trials involving the treatment of TNBCs with radical ICIs therapies, including combinational therapies that include ICI technologies. In this review, we prov...
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#1ShadabH-Index: 22
#2Nabil A. AlhakamyH-Index: 12
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Plumbagin (PLM) is a phytochemical which has shown cytotoxicity against of cancer cells both in vitro and in vivo. However, the clinical application of PLM has been hindered due to poor aqueous solubility and low bioavailability. The aim of the present study was to develop, optimize and evaluate PLM-loaded glycerosome (GM) gel and compare with conventional liposome (CL) for therapeutic efficacy against skin cancer. The GM formulations were optimized by employing design expert software by 3-level...
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#1Shaimaa M. Badr-Eldin (Cairo University)H-Index: 11
#2Hibah M. Aldawsari (KAU: King Abdulaziz University)H-Index: 12
Last. Usama A. Fahmy (KAU: King Abdulaziz University)H-Index: 12
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Abstract Raloxifene hydrochloride (RLX) is a selective estrogen receptor modulator used for treatment and protection against postmenopausal osteoporosis. The drug has been used for protection against breast cancer and more recently, for management of the disease by virtue of its estrogen antagonist action. However, the drug has reduced bioavailability related to low water solubility and first pass metabolism. To surmount these pitfalls, this study aimed at developing and optimizing RLX-loaded se...
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#1Nabil A. AlhakamyH-Index: 12
#2Osama A. A. AhmedH-Index: 9
Last. ShadabH-Index: 22
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#1Nadeem Ali (KAU: King Abdulaziz University)H-Index: 26
#2Syed Ali Musstjab Akber Shah Eqani (CUI: COMSATS Institute of Information Technology)H-Index: 24
Last. Hussain Mohammed Salem Ali Albar (KAU: King Abdulaziz University)H-Index: 5
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1 CitationsSource
#1Mohammed W. Al-Rabia (KAU: King Abdulaziz University)H-Index: 4
#2Nabil A. Alhakamy (KAU: King Abdulaziz University)H-Index: 12
Last. Usama A. Fahmy (KAU: King Abdulaziz University)H-Index: 12
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The outbreak of the COVID-19 pandemic in China has become an urgent health and economic challenge. The objective of the current work was to evaluate the efficacy of the combined complex of Sitagliptin (SIT) with melittin (MEL) against SARS-CoV-2 virus. SIT-MEL nano-conjugates were optimized by a full three-factor bi-level (23) factorial design. In addition, SIT concentration (mM, X1), MEL concentration (mM, X2), and pH (X3) were selected as the critical factors. Particle size (nm, Y1) and zeta p...
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#1Nabil A. AlhakamyH-Index: 12
#2Osama A. A. AhmedH-Index: 9
Last. Giuseppe CarusoH-Index: 27
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The outbreak of the COVID-19 pandemic in China has become an urgent health and economic challenge. There is a current race for developing strategies to treat and/or prevent COVID-19 worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the strain of coronavirus that causes COVID-19. The aim of the present work was to evaluate the efficacy of the combined complex (nano-conjugates) of two FDA-approved drugs, sitagliptin (SIT) and glatiramer acetate (GA), against a human isolat...
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#1Ameeduzzafar ZafarH-Index: 3
#2Nabil K. AlruwailiH-Index: 6
Last. Mohamed F. Ibrahim (Al-Azhar University)H-Index: 1
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Abstract Aim Diabetic (type-2) is a metabolic disease characterized by increased blood glucose level from the normal level. In the present study, apigenin (AG) loaded lipid vesicles (bilosomes: BIL) was prepared, optimized and evaluated for the oral therapeutic efficacy. Experimental AG-BIL was prepared by a thin-film evaporation method using cholesterol, span 60 and sodium deoxycholate. The prepared formulation was optimized by 3-factor and 3-level Box-Behnken design using particle size, entrap...
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In this study, we measured the occurrence of organophosphate esters (OPEs) and phthalates in the settled dust (floor and air conditioner filter dust) and in suspended particulate matter (PM10) from different microenvironments (households (n = 20), offices (n = 10) and hotels (n = 10)) of Jeddah, Saudi Arabia. Bis (2-Ethylhexyl) phthalate (DEHP) was the major pollutant (contributing > 85% of total chemicals burden) in all types of indoor dust with a concentration up to 3,901,500 ng g−1. While dib...
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#1Naveed AhmadH-Index: 11
Last. Mohammed H. ElkomyH-Index: 11
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Wound infections are one of the major reasons for the delay in the healing of chronic wounds and can be overcome by developing effective wound dressings capable of absorbing exudate, providing local antibiotic release, and improving patient comfort. Arabinoxylan (AX) is a major hemicellulose present in psyllium seed husk (PSH) and exhibits promising characteristics for developing film dressings. Herein, AX-gelatin (GL) films were prepared by blending AX, gelatin (GL), glycerol, and gentamicin (a...
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