Usama A. Fahmy
King Abdulaziz University
CytotoxicityPharmacokineticsCytotoxic T cellSolubilityBioavailabilityChemistryParticle sizeApoptosisTransdermalIn vivoSimvastatinPolyethylene glycolIC50Drug deliveryDrugChromatographyPermeationZeta potentialAnnexinPharmacology
67Publications
12H-index
400Citations
Publications 65
Newest
#1Shaimaa M. Badr-Eldin (Cairo University)H-Index: 11
#2Hibah M. Aldawsari (KAU: King Abdulaziz University)H-Index: 12
Last. Usama A. Fahmy (KAU: King Abdulaziz University)H-Index: 12
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Abstract Raloxifene hydrochloride (RLX) is a selective estrogen receptor modulator used for treatment and protection against postmenopausal osteoporosis. The drug has been used for protection against breast cancer and more recently, for management of the disease by virtue of its estrogen antagonist action. However, the drug has reduced bioavailability related to low water solubility and first pass metabolism. To surmount these pitfalls, this study aimed at developing and optimizing RLX-loaded se...
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#1Nabil A. AlhakamyH-Index: 12
#2Osama A. A. AhmedH-Index: 9
Last. ShadabH-Index: 22
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#1Mohammed W. Al-Rabia (KAU: King Abdulaziz University)H-Index: 4
#2Nabil A. Alhakamy (KAU: King Abdulaziz University)H-Index: 12
Last. Usama A. Fahmy (KAU: King Abdulaziz University)H-Index: 12
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The outbreak of the COVID-19 pandemic in China has become an urgent health and economic challenge. The objective of the current work was to evaluate the efficacy of the combined complex of Sitagliptin (SIT) with melittin (MEL) against SARS-CoV-2 virus. SIT-MEL nano-conjugates were optimized by a full three-factor bi-level (23) factorial design. In addition, SIT concentration (mM, X1), MEL concentration (mM, X2), and pH (X3) were selected as the critical factors. Particle size (nm, Y1) and zeta p...
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#1Nabil A. AlhakamyH-Index: 12
#2Osama A. A. AhmedH-Index: 9
Last. Giuseppe CarusoH-Index: 27
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The outbreak of the COVID-19 pandemic in China has become an urgent health and economic challenge. There is a current race for developing strategies to treat and/or prevent COVID-19 worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the strain of coronavirus that causes COVID-19. The aim of the present work was to evaluate the efficacy of the combined complex (nano-conjugates) of two FDA-approved drugs, sitagliptin (SIT) and glatiramer acetate (GA), against a human isolat...
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#2Nabil A. AlhakamyH-Index: 12
Last. Giuseppe CarusoH-Index: 27
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Fluvastatin (FLV) is a hydroxymethylglutaryl coenzyme A (HMG‐CoA) reductase inhibitor often used to lower total and low-density lipoprotein (LDL) cholesterol and for the prevention of adverse cardiovascular events. This drug as well as melittin (MEL), the major component of honeybee venom (Apis mellifera), have shown antineoplastic activity, then representing promising approaches for cancer therapy. However, adverse effects related to the use of FLV and MEL have been reported and very few studie...
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Euryops arabicus Steud (E. arabicus) belongs to the family Asteraceae. It has several uses in folk medicine in the Arabian Peninsula. The current study aimed at evaluating the wound healing properties of the E. arabicus extract in rats. Primarily, E. arabicus successfully accelerated cell migration in vitro and it also showed no signs of dermal toxicity. Topical application of E. arabicus extract (5% or 20%) expedited healing of excised skin in rats. Histological examinations indicated that E. a...
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#1Usama A. Fahmy (KAU: King Abdulaziz University)H-Index: 12
#2Omar Fahmy (UPM: Universiti Putra Malaysia)H-Index: 10
Last. Nabil A. Alhakamy (KAU: King Abdulaziz University)H-Index: 12
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Clinical application of icariin (ICA) is limited, despite its activity against cancer growth, because of the low solubility of ICA in an aqueous environment. Therefore, the present study attempted to develop and optimize ICA-loaded cubosome delivery and to explore its efficacy and possible mechanism of action against ovarian cancer. The optimization of the cubosome formulation was performed using the Box‒Behnken statistical design; during the characterization, the particle sizes were in the rang...
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