Kishio Toma
Okayama University
Dopamine receptor D1Internal medicineDownregulation and upregulationEndocrinologySomatostatin receptor 2DermatologyEndogenyReceptorChemistryOrexin-ASomatostatinOocyteMelatoninGonadotropin-releasing hormoneProlactinPasireotideLuzindoleBone morphogenetic proteinSomatostatin receptor 3MAPK/ERK pathwaySomatostatin receptor 1MedicineSomatostatin receptorCholesterol side-chain cleavage enzymeBiology
15Publications
8H-index
138Citations
Publications 15
Newest
#1Natsumi Matsuoka (Okayama University)H-Index: 1
#2Kenji Tsuji (Okayama University)H-Index: 8
Last. Jun Wada (Okayama University)H-Index: 63
view all 10 authors...
BACKGROUND: The advent of immune checkpoint inhibitors (ICIs) has significantly improved the prognosis of patients with advanced malignancies. On the other hand, these drugs might cause immune-related adverse events (irAEs) including endocrinopathies and nephropathies. Thyroid dysfunction is one of the most common irAEs. For ICIs-induced nephropathies, most cases are due to tubulointerstitial nephritis, which might require steroid treatment. Here, we report a patient with non-small cell lung can...
2 CitationsSource
#1Tomoyo Mifune-Morioka (Okayama University)
#2Haruhito A. Uchida (Okayama University)H-Index: 15
Last. Jun WadaH-Index: 63
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Eight years prior to her present admission, a 61-year-old Japanese woman was diagnosed with autoimmune hepatitis, slowly progressive insulin-dependent diabetes mellitus, and chronic thyroiditis; she had been treated with oral prednisolone (PSL). After she suddenly discontinued PSL, she newly developed systemic lupus erythematosus. A combination therapy of oral PSL and intravenous cyclophosphamide resulted in remission. She was finally diagnosed with autoimmune polyglandular syndrome (APS) type 3...
Source
#1Satoshi Fujisawa (Okayama University)H-Index: 3
#2Motoshi Komatsubara (Okayama University)H-Index: 5
Last. Fumio Otsuka (Okayama University)H-Index: 35
view all 8 authors...
Abstract The impact of orexins on anterior pituitary function has yet to be clarified. We studied the effects of orexin A and its interaction with the bone morphogenetic protein (BMP) system on the regulatory role of prolactin synthesis using rat lactotrope GH3 cells expressing BMP-4. Orexin type 1 receptor (OX1R), but not type 2 receptor (OX2R), was predominantly expressed in GH3 cells. Orexin A suppressed forskolin-induced, but not basal, prolactin mRNA expression without reducing cAMP levels....
2 CitationsSource
#1Satoshi Fujisawa (Okayama University)H-Index: 3
#2Motoshi Komatsubara (Okayama University)H-Index: 5
Last. Fumio Otsuka (Okayama University)H-Index: 35
view all 9 authors...
Source
#1Motoshi Komatsubara (Okayama University)H-Index: 5
#2Takayuki Hara (Okayama University)H-Index: 4
Last. Fumio Otsuka (Okayama University)H-Index: 35
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Abstract Melatonin is functionally involved in the control of circadian rhythm and hormonal secretion. In the present study, we investigated the roles of melatonin in the interaction of catecholamine synthesis with adrenocortical steroids by focusing on bone morphogenetic protein (BMP)-4 expressed in the adrenal medulla using rat pheochromocytoma PC12 cells. Melatonin treatment significantly reduced the mRNA expression of catecholamine synthases, including the rate-limiting enzyme tyrosine hydro...
10 CitationsSource
#1Kishio Toma (Okayama University)H-Index: 8
#2Fumio Otsuka (Okayama University)H-Index: 35
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 8 authors...
The effects of somatostatin analogs and roles of BMP-6 in the regulation of luteinizing hormone (LH) secretion were investigated using mouse gonadotrope LβT2 cells. LH mRNA expression and LH secretion induced by GnRH were suppressed by treatments with somatostatin analogs, including octreotide and pasireotide, in LβT2 cells. Of note, the inhibitory effects of somatostatin analogs on LH secretion were enhanced by the action of BMP-6. BMP-6 increased the expression levels of somatostatin receptor ...
6 CitationsSource
#1Takeshi Hosoya (Okayama University)H-Index: 6
#2Fumio Otsuka (Okayama University)H-Index: 35
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 10 authors...
Abstract BMPs expressed in the ovary differentially regulate steroidogenesis by granulosa cells. BMP-9, a circulating BMP, is associated with cell proliferation, apoptosis and differentiation in various tissues. However, the effects of BMP-9 on ovarian function have yet to be elucidated. Here we investigated BMP-9 actions on steroidogenesis using rat primary granulosa cells. BMP-9 potently suppressed FSH-induced progesterone production, whereas it did not affect FSH-induced estradiol production ...
16 CitationsSource
#1Eri Nakamura (Okayama University)H-Index: 13
#2Fumio Otsuka (Okayama University)H-Index: 35
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 8 authors...
Abstract The ovarian bone morphogenetic protein (BMP) system is a physiological inhibitor of luteinization in growing ovarian follicles. BMP-6, which is expressed in oocytes and granulosa cells of healthy follicles, specifically inhibits FSH actions by suppressing adenylate cyclase activity. In the present study, we studied the role of melatonin in ovarian steroidogenesis using rat primary granulosa cells of immature female rat ovaries by focusing on the interaction with BMP-6 activity. Treatmen...
16 CitationsSource
#1Takayuki Katsuyama (Okayama University)H-Index: 10
#2Haruhito A. Uchida (Okayama University)H-Index: 15
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 8 authors...
A 71-year-old woman presented with a high-grade fever, neck pain, anemia and thrombocytopenia. After performing further examinations, we concluded that she had simultaneously developed large vessel vasculitis and myelodysplastic syndrome (MDS). Although glucocorticoid administration improved her clinical symptoms, the MDS transformed into acute myeloid leukemia and she died one year after receiving the diagnosis. The occurrence of immune-mediated disorders in patients with MDS is a well-known ph...
8 CitationsSource
#1Tomohiro Terasaka (Okayama University)H-Index: 10
#2Fumio Otsuka (Okayama University)H-Index: 35
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 10 authors...
Reproduction is integrated by interaction of neural and hormonal signals converging on hypothalamic neurons for controlling gonadotropin-releasing hormone (GnRH). Kisspeptin, the peptide product of the kiss1 gene and the endogenous agonist for the GRP54 receptor, plays a key role in the regulation of GnRH secretion. In the present study, we investigated the interaction between kisspeptin, estrogen and BMPs in the regulation of GnRH production by using mouse hypothalamic GT1-7 cells. Treatment wi...
29 CitationsSource