Tomoo Kosuge
University of Tokyo
CancerInternal medicineRadiologySurgeryPathologyOncologySurvival ratePancreatic diseaseHepatectomyCarcinomaHepatocellular carcinomaPancreasPancreaticoduodenectomyMetastasisPancreatic cancerAdenocarcinomaGeneral surgeryMedicineBiologyGastroenterology
Publications 321
#1Itaru EndoH-Index: 66
#2Norimichi Hirahara (UTokyo: University of Tokyo)H-Index: 10
Last. Masaru MiyazakiH-Index: 79
view all 20 authors...
BACKGROUND The high operative mortality rate after hepatopancreatoduodenectomy (HPD) is still a major issue. The present study explored why the operative mortality differs significantly by hospital volume. METHOD Surgical case data were extracted from the National Clinical Database (NCD) in Japan from 2011 to 2014. Surgical procedures were categorized as major (≥2 sections) and minor (<2 sections) hepatectomy. Hospitals were categorized according to the certification system by the Japanese Socie...
#1Yasuro Futagawa (Jikei University School of Medicine)H-Index: 12
#2Katsuhiko Yanaga (Jikei University School of Medicine)H-Index: 63
Last. Hiroki Yamaue (Wakayama Medical University)H-Index: 69
view all 9 authors...
BACKGROUND: Since there is no reliable evidence on the safety of pancreaticoduodenectomy (PD) in chronic hepatic dysfunction (CHD) including liver cirrhosis (LC), the effects of CHD on patients undergoing PD were investigated. METHODS: This multi-institutional retrospective study analyzed 529 patients with CHD, including 105 patients diagnosed with LC, who underwent PD at 82 high-volume institutions between 2004 and 2013. RESULTS: The in-hospital mortality rate was 5.9%. The incidence of postope...
#1Sohei Satoi (Kansai Medical University)H-Index: 33
#2Michiaki Unno (Tohoku University)H-Index: 69
Last. Tomoo KosugeH-Index: 86
view all 15 authors...
4126Background: Despite recent progress of adjuvant chemotherapy for resected pancreatic ductal adenocarcinoma (PDAC), its survival remains limited. We conducted a randomized controlled trial to co...
#1Fuyuhiko Motoi (Tohoku University)H-Index: 41
#2Tomoo KosugeH-Index: 86
Last. Michiaki Unno (Tohoku University)H-Index: 69
view all 12 authors...
: A randomized, controlled trial has begun to compare neoadjuvant chemotherapy using gemcitabine and S-1 with upfront surgery for patients planned resection of pancreatic cancer. Patients were enrolled after the diagnosis of resectable or borderline resectable by portal vein involvement pancreatic cancer with histological confirmation. They were randomly assigned to either neoadjuvant chemotherapy or upfront surgery. Adjuvant chemotherapy using S-1 was administered for 6 months to patients with ...
#1Yoshihiko MaeharaH-Index: 108
#2Ken Shirabe (Kyushu University)H-Index: 77
Last. Mototsugu ShimokawaH-Index: 22
view all 29 authors...
#1Yuichi Hirata (Kobe University)H-Index: 3
#2Takashi Kobayashi (Kobe University)H-Index: 15
Last. Masaru Yoshida (Kobe University)H-Index: 63
view all 25 authors...
Abstract Background To improve prognosis of pancreatic cancer (PC) patients, the discovery of more reliable biomarkers for the early detection is desired. Methods Blood samples were collected by 2 independent groups. The 1st set was included 55 early PC and 58 healthy volunteers (HV), and the 2nd set was included 16 PC and 16 HV. The 16 targeted metabolites were quantitatively analyzed by gas chromatography/tandem mass spectrometry together with their corresponding stable isotopes. In the 1st se...
#1Yoshihiko Maehara (Kyushu University)H-Index: 108
#2Ken Shirabe (Kyushu University)H-Index: 77
Last. Mototsugu ShimokawaH-Index: 22
view all 29 authors...
Background The use of absorbable sutures in wound closure has been shown to reduce the incidence of surgical site infection (SSI); however, there is no evidence that the intra-abdominal use of absorbable rather than silk sutures reduces the incidence of SSI after gastrointestinal surgery. We report the findings of a phase II trial, designed to evaluate the impact of the intra-abdominal use of absorbable sutures on the incidence of SSI.
#4Seiji Oguro (National Cancer Research Institute)H-Index: 6
As macroscopic appearance represents tumor microenvironment, it may also reflect the biological and clinicopathological characteristics of a cancer. The aim of the study was to evaluate the clinicopathological significance of the gross appearance of pancreatic ductal adenocarcinoma (PDA). We investigated fresh macroscopic features in 352 cases of PDA and their clinicopathological significance. Three unique gross features were found: a honeycomb-like appearance (diffusely distributed microcysts a...
#1Toshihiro Yoneyama (Tohoku University)H-Index: 4
#2Sumio Ohtsuki (Kumamoto University)H-Index: 70
Last. Tetsuya Terasaki (Tohoku University)H-Index: 89
view all 23 authors...
Pancreatic cancer is one of the most lethal tumors, and reliable detection of early-stage pancreatic cancer and risk diseases for pancreatic cancer is essential to improve the prognosis. As 260 genes were previously reported to be upregulated in invasive ductal adenocarcinoma of pancreas (IDACP) cells, quantification of the corresponding proteins in plasma might be useful for IDACP diagnosis. Therefore, the purpose of the present study was to identify plasma biomarkers for early detection of IDA...
#1Nobuyuki TakemuraH-Index: 10
#2Hideaki MitaH-Index: 1
Last. Tomoo KosugeH-Index: 86
view all 5 authors...
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