Andrea Natali
University of Pisa
Internal medicineEndocrinologyCardiologyCarbohydrate metabolismChemistryEssential hypertensionType 2 diabetesInsulin resistanceGlucose uptakeGlucose clamp techniqueInsulinPancreatic hormoneGlucose tolerance testHyperinsulinemiaPopulationObesityDiabetes mellitusMedicineBlood pressureBiology
216Publications
61H-index
10.1kCitations
Publications 252
Newest
#1Chuanyan Wu (SDU: Shandong University)H-Index: 3
#2Yan Borné (Lund University)H-Index: 19
Last. Andreas Peter (University of Tübingen)H-Index: 38
view all 42 authors...
The hepatokine follistatin is elevated in patients with type 2 diabetes (T2D) and promotes hyperglycemia in mice. Here we explore the relationship of plasma follistatin levels with incident T2D and mechanisms involved. Adjusted hazard ratio (HR) per standard deviation (SD) increase in follistatin levels for T2D is 1.24 (CI: 1.04–1.47, p < 0.05) during 19-year follow-up (n = 4060, Sweden); and 1.31 (CI: 1.09–1.58, p < 0.01) during 4-year follow-up (n = 883, Finland). High circulating follistatin ...
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#1Arturo PujiaH-Index: 34
#2Tiziana MontalciniH-Index: 25
Last. Angela A. Rivellese (University of Naples Federico II)H-Index: 53
view all 15 authors...
Abstract null null Epidemiological evidence has confirmed the potential causal relationship between specific dietary factors and non-communicable diseases. However, currently nutrition was shown to be insufficiently integrated into medical education, regardless of the country. Without an adequate nutrition education, it is reasonable to assume that future physicians, as well as other health care professionals, will be not able to provide the highest quality care to patients in preventing and tre...
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#1Annelie ShamiH-Index: 7
#2Andreas EdsfeldtH-Index: 16
Last. Isabel GonçalvesH-Index: 26
view all 9 authors...
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#1Andrea Natali (UniPi: University of Pisa)H-Index: 61
#2Lorenzo Nesti (UniPi: University of Pisa)H-Index: 8
Last. Ele FerranniniH-Index: 101
view all 4 authors...
The impressive results of recent clinical trials with glucagon-like peptide-1 receptor agonists (GLP-1Ra) and sodium glucose transporter 2 inhibitors (SGLT-2i) in terms of cardiovascular protection prompted a huge interest in these agents for heart failure (HF) prevention and treatment. While both classes show positive effects on composite cardiovascular endpoints (i.e. 3P MACE), their actions on the cardiac function and structure, as well as on volume regulation, and their impact on HF-related ...
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#1Andrea Natali (UniPi: University of Pisa)H-Index: 61
#2Lorenzo Nesti (UniPi: University of Pisa)H-Index: 8
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#1Martina Chiriacò (UniPi: University of Pisa)H-Index: 5
#2Luca Sacchetta (UniPi: University of Pisa)
Last. Domenico Tricò (UniPi: University of Pisa)H-Index: 15
view all 9 authors...
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#1Roberto BizzottoH-Index: 7
#2Domenico Tricò (UniPi: University of Pisa)H-Index: 15
Last. Andrea MariH-Index: 32
view all 9 authors...
OBJECTIVE null Endogenous insulin clearance (EIC) is physiologically reduced at increasing insulin secretion rate (ISR). Computing EIC at the prevailing ISR does not distinguish the effects of hypersecretion from those of other mechanisms of glucose homeostasis. We aimed to measure EIC in standardized ISR conditions (i.e., at fixed ISR levels) and to analyze its associations with relevant physiologic factors. null RESEARCH DESIGN AND METHODS null We estimated standardized EIC (EICISR) by mathema...
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#1Rain Yamamoto (Harvard University)H-Index: 3
#2Majken K. Jensen (UCPH: University of Copenhagen)H-Index: 57
Last. Frank M. Sacks (Harvard University)H-Index: 136
view all 11 authors...
CONTEXT HDL in humans is composed of a heterogeneous group of particles varying in protein composition as well as biological effects. OBJECTIVE We investigated the prospective associations between HDL subspecies containing and lacking apoC-III at baseline and insulin sensitivity at year 3. DESIGN, SETTING, AND PARTICIPANTS A prospective cohort study of 864 healthy volunteers drawn from the RISC study, a multi-center European clinical investigation, whose recruitment initiated in 2002 with a foll...
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#1Martina Chiriacò (UniPi: University of Pisa)H-Index: 5
#2Domenico Tricò (UniPi: University of Pisa)H-Index: 15
Last. Andrea Natali (UniPi: University of Pisa)H-Index: 61
view all 9 authors...
The pathophysiological link between adiposity and blood pressure is not completely understood, and evidence suggests an influence of sex and genetic determinants. We aimed to identify the relations...
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#1Lorenzo Nesti (UniPi: University of Pisa)H-Index: 8
#2Nicola Riccardo Pugliese (UniPi: University of Pisa)H-Index: 12
Last. Andrea Natali (UniPi: University of Pisa)H-Index: 61
view all 9 authors...
BACKGROUND Type 2 diabetes mellitus (T2D) increases the risk of incident heart failure (HF), whose earliest fingerprint is effort intolerance (i.e. impaired peak oxygen consumption, or VO2peak). In the uncomplicated T2D population, however, the prevalence of effort intolerance and the underpinning mechanistic bases are uncertain. Leveraging the multiparametric characterization allowed by imaging-cardiopulmonary exercise testing (iCPET), the aim of this study is to quantify effort intolerance in ...
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