Raja Marrakchi
Tunis University
GeneCancerInternal medicineEndocrinologyGenotypePathologyOncologyCase-control studyImmunologyBladder cancerPopulationGynecologyMethylenetetrahydrofolate reductaseCancer researchRisk factorThyroidColorectal cancerBreast cancerGeneticsMedicineBiologyGastroenterology
72Publications
18H-index
692Citations
Publications 72
Newest
Last. Pham Quang ThangH-Index: 1
view all 38 authors...
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Systemic sclerosis (SSc) is an autoimmune disorder characterized by vascular damage, excessive fibrosis and abnormal T cells immune-regulation. CD146 is an adhesion molecule essentially expressed in the vascular system, but also on TH17 lymphocytes. In view of the recently described role of CD146 in SSc, we hypothesized an involvement of CD146 positive TH17 cells in this disease. Compared to healthy controls, we showed that both soluble form of CD146 (sCD146), and IL17A levels were increased in ...
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#1Kaouther Nasri (Carthage University)H-Index: 4
#2Fatma MidaniH-Index: 3
Last. Raja MarrakchiH-Index: 18
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OBJECTIVE: This study aims to investigate the association of 5,10-methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) and methionine synthase reductase (MTRR A66G) gene polymorphisms with neural tube defects (NTDs) in a Tunisian population. METHODS: Genotyping was performed by polymerase chain reaction with restriction fragment length polymorphisms (PCR-RFLPs) using the restriction enzymes. Allele and genotype frequencies were compared between mothers and fathers of fetuses with NTDs wi...
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#1Ines Bini Dhouib (Tunis University)H-Index: 9
#2Alya Annabi (Tunis University)H-Index: 14
Last. Asma Gati (Tunis University)H-Index: 3
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Curcumin is a molecule found in turmeric root that has anti-inflammatory, antioxidant, and anti-tumor properties and has been widely used as both an herbal drug and a food additive to treat or prevent neurodegenerative diseases. This study aimed to investigate the effect of curcumin on neurobehavioral and neuropathological alterations induced by acetamiprid on male rats. Three groups of ten male Wistar rats each were used for the study: the first was a control group (CTR) that did not consume ac...
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#1Meriem El Aloui (Carthage University)H-Index: 3
#2Kaouther Nasri (Carthage University)H-Index: 4
Last. Raja Marrakchi (Tunis University)H-Index: 18
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Abstract Background For Down syndrome (DS), traditional epidemiological studies to determine the prevalence, cause, and clinical significance of the syndrome have been conducted over the last 100 years. In Tunisia, the current work is the first in-depth study in epidemiology of DS from fetopathological data. Aim of the study The aim of this epidemiological study was to determine the impact of some feto-maternal characteristics in occurrence of DS and to search the frequency of associated congeni...
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#1Meriem El Aloui (Carthage University)H-Index: 3
#2Kaouther Nasri (Carthage University)H-Index: 4
Last. Raja Marrakchi (Tunis University)H-Index: 18
view all 7 authors...
Abstract Background Despite the high risk of recurrence of congenital malformations, there are no well-accepted preventive measures in developing countries like Tunisia. It is recommended that thorough epidemiological studies of congenital anomalies in this country are needed. The aim of this study is to assess the frequency and types of congenital anomalies in Tunisia and research some risk factors associated with occurrence of these anomalies. Methods In this retrospective study, all the fetus...
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#1Kaouther Nasri (Tunis El Manar University)H-Index: 4
#2Mohamed Kacem Ben Fradj (Tunis El Manar University)H-Index: 9
Last. Soumeya Siala Gaigi (Tunis El Manar University)H-Index: 5
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Abstract Objective To determine whether low vitamin D levels in pregnant women are associated with the occurrence of neural tube defects (NTDs) in Tunisia. Methods In a prospective study, pregnant women were recruited at a center in Tunis between January 1, 2012, and December 30, 2013. Women carrying a fetus with a severe NTD were recruited before elective termination. Matched, healthy pregnancy women were enrolled into a control group. Plasma levels of 25-hydroxyvitamin D were measured by a com...
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#1Khouloud Hamdi (Tunis University)H-Index: 4
#2Jan BlancatoH-Index: 19
Last. Raja MarrakchiH-Index: 18
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: Recent discovery showing the presence of microRNAs (miRNAs) in the circulation sparked interest in their use as potential biomarkers. Our previous studies showed the diagnostic potential of miR-451 as a serological marker for inflammatory breast cancer (IBC), miR-337- 5p and miR-30b for non-inflammatory breast cancer (non-IBC). The aim of this study is to investigate the prognostic values of circulating miRNAs by comparing the amounts of 12 circulating miRNAs in the serum of IBC and non-IBC fr...
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#1Kaouther Nasri (Tunis University)H-Index: 4
#2Mohamed Kacem Ben Fradj (Tunis University)H-Index: 9
Last. Soumeya Siala Gaigi (Tunis University)H-Index: 5
view all 12 authors...
Background This study was conducted to determine whether low folate and vitamin B12 levels, as well as high homocysteine levels in pregnant women are associated with neural tube defects (NTDs) in Tunisia. Methods A total of 75 NTDs pregnancies and 75 matched controls were included in the study. Their vitamin B12, folate, and red blood cell folate concentrations were measured using a radio-immunoassay kit and total homocysteine concentrations were determined using a fluorescent polarization immun...
Source
#1Kaouther Nasri (Carthage University)H-Index: 4
#2Mohamed Kacem Ben Fradj (Tunis University)H-Index: 9
Last. Soumeya Siala Gaigi (Tunis University)H-Index: 5
view all 8 authors...
Abstract Background The term spina bifida refers to a group of neural tube defects that result in malformations of the spinal cord and the surrounding vertebrae. Though the etiologies of spina bifida remain largely unknown, several risk factors have been identified, including feto-maternal characteristics. Aim of the study To discover possible underlying reasons for the increase of spina bifida and identify intervention targets, an investigation was undertaken comparing spina bifida-affected pre...
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