Timothy M. Olson
Mayo Clinic
GeneInternal medicineEndocrinologyPathologyCardiologyExome sequencingNatriuretic peptideDilated cardiomyopathyAtrial natriuretic peptideHeart failureCardiomyopathyAtrial fibrillationHypoplastic left heart syndromeHeart diseasePopulationMutationGeneticsGenetic heterogeneityMedicineMissense mutationBiology
125Publications
31H-index
4,620Citations
Publications 123
Newest
#1Tamiel N. Turley (Mayo Clinic)H-Index: 3
#2Matthew L. Kosel (Mayo Clinic)H-Index: 22
Last. Timothy M. Olson (Mayo Clinic)H-Index: 31
view all 7 authors...
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#7Wei Guo (UW: University of Wyoming)
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#1Maengjo Kim (Mayo Clinic)H-Index: 11
#2Linghui Lu (Mayo Clinic)
Last. Xiaolei Xu (Mayo Clinic)H-Index: 25
view all 9 authors...
A de novo missense variant in Rag GTPase protein C (RagCS75Y) was recently identified in a syndromic dilated cardiomyopathy (DCM) patient. However, its pathogenicity and the related therapeutic strategy remain unclear. We generated a zebrafish RragcS56Y (corresponding to human RagCS75Y) knock-in (KI) line via TALEN technology. The KI fish manifested cardiomyopathy-like phenotypes and poor survival. Overexpression of RagCS75Y via adenovirus infection also led to increased cell size and fetal gene...
1 CitationsSource
#1Talha NiazH-Index: 8
#2Jonathan N. Johnson (Mayo Clinic)H-Index: 30
Last. Donald J. Hagler (Mayo Clinic)H-Index: 88
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1. Talha Niaz, MBBS* 2. Jonathan N. Johnson, MD*,† 3. Frank Cetta, MD*,† 4. Timothy M. Olson, MD*,† 5. Donald J. Hagler, MD*,† 1. *Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, and 2. †Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN * Abbreviations: AHA : : American Heart Association BAV : : bicuspid aortic valve TTE : : transthoracic echocardiography Bicuspid aortic valve is the most common congenital heart defect in children, adolescents, ...
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#2Joseph A. Dearani (UR: University of Rochester)H-Index: 95
#5Bryan C. Cannon (UR: University of Rochester)H-Index: 29
Last. Karen Cavanaugh (Mayo Clinic)H-Index: 2
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Abstract Background The objective of this study is to assess the safety and early impact of intramyocardial delivery of autologous bone marrow-derived mononuclear cells (BM-MNC) at time of surgical Ebstein repair. Methods Patients with EA (ages 6 months to 30 years) scheduled to undergo repair of the TV were eligible to participate in this open label, non-randomized Phase I clinical trial. BM-MNC target dose was 1-3 million cells/kg. Ten patients have undergone surgical intervention and cell del...
2 CitationsSource
#1Jeanne L. Theis (Mayo Clinic)H-Index: 11
#2Jessie J. Hu (Mayo Clinic)H-Index: 1
Last. Timothy M. Olson (Mayo Clinic)H-Index: 31
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BACKGROUND Hypoplastic left heart syndrome (HLHS) with risk of poor outcome has been linked to MYH6 variants, implicating overlap in genetic etiologies of structural and myopathic heart disease. METHODS Whole genome sequencing was performed in 197 probands with HLHS, 43 family members, and 813 controls. Data were filtered for rare, segregating variants in 3 index families comprised of an HLHS proband and relative(s) with cardiomyopathy. Whole genome sequencing data from cases and controls were c...
3 CitationsSource
#7Wei Guo (UW: University of Wyoming)
Ribonucleoprotein (RNP) granules are biomolecular condensates-liquid-liquid phase-separated droplets that organize and manage messenger RNA metabolism, cell signaling, biopolymer assembly, biochemical reactions and stress granule responses to cellular adversity. Dysregulated RNP granules drive neuromuscular degenerative disease but have not previously been linked to heart failure. By exploring the molecular basis of congenital dilated cardiomyopathy (DCM) in genome-edited pigs homozygous for an ...
11 CitationsSource
#1Jeanne L. Theis (UR: University of Rochester)H-Index: 1
#2Georg Vogler (DI: Discovery Institute)H-Index: 12
Last. Rolf Bodmer (DI: Discovery Institute)H-Index: 67
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Congenital heart diseases (CHDs), including hypoplastic left heart syndrome (HLHS), are genetically complex and poorly understood. Here, a multi-disciplinary platform was established to functionally evaluate novel CHD gene candidates, based on whole genome and iPSC RNA sequencing of a HLHS family-trio. Filtering for rare variants and altered expression in proband iPSCs prioritized 10 candidates. siRNA/RNAi-mediated knockdown in generic human iPSC-derived cardiomyocytes (hiPSC-CM) and in developi...
8 CitationsSource
#1Jeanne L. Theis (UR: University of Rochester)H-Index: 1
#2Georg Vogler (DI: Discovery Institute)H-Index: 12
Last. Rolf Bodmer (DI: Discovery Institute)H-Index: 67
view all 21 authors...
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#1Tamiel N. Turley (Mayo Clinic)H-Index: 3
#2Megan M. O’Byrne (Mayo Clinic)H-Index: 29
Last. Timothy M. Olson (Mayo Clinic)H-Index: 31
view all 8 authors...
Importance Spontaneous coronary artery dissection (SCAD), an idiopathic disorder that predominantly affects young to middle-aged women, has emerged as an important cause of acute coronary syndrome, myocardial infarction, and sudden cardiac death. Objective To identify common single-nucleotide variants (SNVs) associated with SCAD susceptibility. Design, Setting, and Participants This single-center genome-wide association study examined approximately 5 million genotyped and imputed SNVs and subseq...
14 CitationsSource