Fieke E.M. Froeling
University of Glasgow
Lymph node stromal cellInternal medicinePhenotypeCell migrationPathologyOncologyStromal cellHepatic stellate cellChemistryIntegrinImmunologyChemotherapyDiseaseRhoCPancreatic cancerGemcitabineRetinoic acidAdenocarcinomaPhases of clinical researchCancer researchStromaClinical trialMedicineCell cultureBiologyCell biologyCancer cell
41Publications
15H-index
1,161Citations
Publications 23
Newest
#1Hemant M. KocherH-Index: 41
#2Bristi BasuH-Index: 19
Last. David PropperH-Index: 27
view all 21 authors...
Source
#1Hemant M. Kocher (QMUL: Queen Mary University of London)H-Index: 41
#2Bristi Basu (Cambridge University Hospitals NHS Foundation Trust)H-Index: 19
Last. David Propper (QMUL: Queen Mary University of London)H-Index: 27
view all 21 authors...
Pre-clinical models have shown that targeting pancreatic stellate cells with all-trans-retinoic-acid (ATRA) reprograms pancreatic stroma to suppress pancreatic ductal adenocarcinoma (PDAC) growth. Here, in a phase Ib, dose escalation and expansion, trial for patients with advanced, unresectable PDAC (n = 27), ATRA is re-purposed as a stromal-targeting agent in combination with gemcitabine-nab-paclitaxel chemotherapy using a two-step adaptive continual re-assessment method trial design. The maxim...
21 CitationsSource
#1Fieke E.M. FroelingH-Index: 15
#2Dennis PlenkerH-Index: 6
Last. David A. TuvesonH-Index: 92
view all 13 authors...
Source
#1Michelle Chan-Seng-Yue (OICR: Ontario Institute for Cancer Research)H-Index: 18
#2J. Kim (OICR: Ontario Institute for Cancer Research)H-Index: 5
Last. Faiyaz Notta (OICR: Ontario Institute for Cancer Research)H-Index: 22
view all 40 authors...
2 CitationsSource
#1Michelle Chan-Seng-Yue (OICR: Ontario Institute for Cancer Research)H-Index: 18
#2J. Kim (OICR: Ontario Institute for Cancer Research)H-Index: 5
Last. Faiyaz Notta (OICR: Ontario Institute for Cancer Research)H-Index: 22
view all 41 authors...
Pancreatic adenocarcinoma presents as a spectrum of a highly aggressive disease in patients. The basis of this disease heterogeneity has proved difficult to resolve due to poor tumor cellularity and extensive genomic instability. To address this, a dataset of whole genomes and transcriptomes was generated from purified epithelium of primary and metastatic tumors. Transcriptome analysis demonstrated that molecular subtypes are a product of a gene expression continuum driven by a mixture of intrat...
99 CitationsSource
#1Hemant M. Kocher (QMUL: Queen Mary University of London)H-Index: 41
#2Bristi Basu (Cambridge University Hospitals NHS Foundation Trust)H-Index: 19
Last. D. Propper (Barts Health NHS Trust)H-Index: 1
view all 18 authors...
Abstract Background Preclinical data demonstrated that we can effectively target pancreatic stellate cells, with measurement of subsequent changes within the stroma, using all trans retinoic acid (ATRA). In a phase I trial we have repurposed ATRA as a stromal targeting agent in combination with gemcitabine and nab-paclitaxel (G-nP). Methods Patients with locally advanced or metastatic pancreatic cancer, who had not received prior systemic therapy for their disease, were eligible. The primary obj...
1 CitationsSource
#1Fieke E.M. FroelingH-Index: 15
#2Nicolas RobineH-Index: 27
Last. David A. TuvesonH-Index: 92
view all 8 authors...
Background and aims Recent advances in DNA sequencing technologies have revolutionized approaches to the prevention, risk assessment, early detection, diagnosis, and treatment of cancers. However, many ethnic groups, especially non-European populations, have been significantly under-represented in cancer research, including clinical trials, and have not received equal benefits in clinical practice. As a result, our current knowledge about tumor biology, cancer risk, and response to treatment has...
Source
#1Hemant M. Kocher (QMUL: Queen Mary University of London)H-Index: 41
#2David Propper (QMUL: Queen Mary University of London)H-Index: 27
Last. Peter Sasieni (QMUL: Queen Mary University of London)H-Index: 77
view all 16 authors...
3 CitationsSource
#1Fieke E.M. Froeling (Imperial College London)H-Index: 15
#2Hemant M. Kocher (QMUL: Queen Mary University of London)H-Index: 41
17 CitationsSource
#1Fieke E.M. Froeling (Imperial College London)H-Index: 15
#2Justin Stebbing (Imperial College London)H-Index: 77
1 CitationsSource