Ana Tellechea
New York University
NeuropeptideEndocrinologyPathologyProinflammatory cytokineChemistryExtracellular matrixProgenitor cellImmunologySubstance PInflammationVascular endothelial growth factorDiabetic footDiabetic foot ulcerWound healingStem cellDegranulationDiabetes mellitusBioinformaticsMedicinePharmacology
22Publications
14H-index
792Citations
Publications 17
Newest
#1Georgios Theocharidis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 6
#2Dimitrios Baltzis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 6
Last. Aristidis Veves (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 76
view all 16 authors...
Non-healing diabetic foot ulceration (DFU) is characterized by low grade chronic inflammation, both locally and systemically. We prospectively followed a group of DFU patients who either healed or developed non-healing chronic DFU. Serum and forearm skin analysis, both at protein expression and transcriptomic level, indicated that increased expression of factors such as IFNγ, VEGF and sVCAM-1 were associated with DFU healing. Furthermore, foot skin single-cell RNA-seq analysis showed multiple fi...
5 CitationsSource
#1Ana Tellechea (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 14
#2Sha Bai (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 3
Last. Aristidis Veves (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 76
view all 20 authors...
ABSTRACT Impaired wound healing in the diabetic foot is a major problem often leading to amputation. Mast cells have been shown to regulate wound healing in diabetes. We developed an indole-carboxamide type mast cell stabilizer, MCS-01, which proved to be an effective mast cell degranulation inhibitor in vitro and can be delivered topically for prolonged periods through controlled release by specifically designed alginate bandages. In diabetic mice, both pre- and post-wounding, topical MCS-01 ap...
13 CitationsSource
#1Olga Kashpur (Tufts University)H-Index: 4
#2Avi Smith (Tufts University)H-Index: 10
Last. Jonathan A. Garlick (Tufts University)H-Index: 33
view all 13 authors...
Diabetic foot ulcers (DFUs) are a major complication of diabetes, and there is a critical need to develop novel cell- and tissue-based therapies to treat these chronic wounds. Induced pluripotent stem cells (iPSCs) offer a replenishing source of allogeneic and autologous cell types that may be beneficial to improve DFU wound-healing outcomes. However, the biologic potential of iPSC-derived cells to treat DFUs has not, to our knowledge, been investigated. Toward that goal, we have performed detai...
12 CitationsSource
#1Ana Tellechea (NYU: New York University)H-Index: 1
#1Ana Tellechea (NYU: New York University)H-Index: 14
Last. Aristidis Veves (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 76
view all 4 authors...
Diabetic peripheral neuropathy and vascular disease, along with trauma, have long been recognized as major risk factors for the development of diabetic foot ulcerations (DFUs). More recently, chronic inflammation, abnormal extracellular matrix (ECM) remodeling, and reduced wound neovascularization, as a result of dysregulated cell function with imbalanced secretion of cytokines, matrix metalloproteinases, and growth factors, have been implicated in DFU failure to heal. Therefore, researchers are...
Source
#1Ana Tellechea (UC: University of Coimbra)H-Index: 14
#2Ermelindo C. Leal (UC: University of Coimbra)H-Index: 22
Last. Aristidis Veves (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 76
view all 18 authors...
Diabetic foot ulceration is a severe complication of diabetes (DM) that lacks effective treatment. Mast cells (MCs) contribute to wound healing, but their role in DM skin is poorly understood. Here we show that the number of degranulated MCs is increased in unwounded forearm and foot skin of DM patients, and unwounded dorsal skin of DM mice (p
46 CitationsSource
#1Kyle P. Quinn (UA: University of Arkansas)H-Index: 24
#2Ermelindo C. Leal (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 22
Last. Irene Georgakoudi (Tufts University)H-Index: 44
view all 7 authors...
22 CitationsSource
#1Ana Tellechea (UC: University of Coimbra)H-Index: 14
#2Eduardo A. Silva (UC Davis: University of California, Davis)H-Index: 26
Last. Aristidis Veves (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 76
view all 9 authors...
Diabetic foot ulcers (DFU) represent a severe health problem and an unmet clinical challenge. In this study, we tested the efficacy of novel biomaterials in improving wound healing in mouse models of diabetes mellitus (DM). The biomaterials are composed of alginate- and deoxyribonucleic acid (DNA)-based gels that allow incorporation of effector cells, such as outgrowth endothelial cells (OEC), and provide sustained release of bioactive factors, such as neuropeptides and growth factors, which hav...
20 CitationsSource
#1Ermelindo C. Leal (UC: University of Coimbra)H-Index: 22
#2Eugénia Carvalho (UC: University of Coimbra)H-Index: 33
Last. Aristidis Veves (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 76
view all 13 authors...
Diabetic foot ulceration is a major complication of diabetes. Substance P (SP) is involved in wound healing, but its effect in diabetic skin wounds is unclear. We examined the effect of exogenous SP delivery on diabetic mouse and rabbit wounds. We also studied the impact of deficiency in SP or its receptor, neurokinin-1 receptor, on wound healing in mouse models. SP treatment improved wound healing in mice and rabbits, whereas the absence of SP or its receptor impaired wound progression in mice....
83 CitationsSource
#1Anna G. Maione (Tufts University)H-Index: 12
#2Yevgeny Brudno (Harvard University)H-Index: 15
Last. Jonathan A. Garlick (Tufts University)H-Index: 33
view all 12 authors...
Diabetic foot ulcers (DFU) are a major, debilitating complication of diabetes mellitus. Unfortunately, many DFUs are refractory to existing treatments and frequently lead to amputation. The development of more effective therapies has been hampered by the lack of predictive in vitro methods to investigate the mechanisms underlying impaired healing. To address this need for realistic wound-healing models, we established patient-derived fibroblasts from DFUs and site-matched controls and used them ...
39 CitationsSource
#2Thanh DinhH-Index: 19
Last. Aristidis VevesH-Index: 76
view all 14 authors...
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