Henry G. Skelton
Quest Diagnostics
CD34PathologyVirologyDermatologyStromal cellImmunologyImmunohistochemistryVirusBiopsyChemotherapyCarcinomaDermisSarcomaBasal cell carcinomaDiseaseImmunopathologyViral diseaseHistopathologyMedicineStainingBiology
173Publications
45H-index
4,613Citations
Publications 172
Newest
#1Kathleen J. Smith (Quest Diagnostics)H-Index: 34
#2Heather HaleyH-Index: 1
Last. Henry G. Skelton (Quest Diagnostics)H-Index: 45
view all 4 authors...
BACKGROUND Protein kinases (PKs) are indispensable for most cellular processes, and deregulation of PKs can lead to activation of oncogenic and anti-apoptotic pathways and immune dysregulation. OBJECTIVE To report the development of keratoacanthoma (KA)-type squamous cell carcinomas (SCCs) in patients treated with the multikinase inhibitor sorafenib for the treatment of solid tumors, to present the possible mechanisms for induction of these SCCs, and to discuss the implications for discontinuati...
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#1A. Hafeez Diwan (University of Texas MD Anderson Cancer Center)H-Index: 23
#2Henry G. Skelton (Quest Diagnostics)H-Index: 45
Last. Kathleen J. Smith (Quest Diagnostics)H-Index: 34
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According to most authors, dermatofibrosarcoma protuberans (DFSP) and giant cell fibroblastoma (GCF) represent the adult and juvenile forms, respectively, of the same disease entity, as evidenced by similar morphology, an identical chromosomal translocation, and CD34 positivity. It has been shown that DFSP and nuchal-type fibroma (NTF) (which is also CD34-positive) are related lesions, and that there might possibly be a continuum between the two. In addition, NTF exhibits CD99 positivity. It was...
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#1Henry G. Skelton (Quest Diagnostics)H-Index: 45
#2H. Edwards (Quest Diagnostics)
Last. Kathleen J. Smith (Quest Diagnostics)H-Index: 34
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Paecilomyces, a hyalohyphomycosis, is an uncommon cause of cutaneous and subcutaneous infections. Most cases reported have occurred in patients with impaired host defenses or following a surgical procedure, and have proven highly resistant to anti fungal therapies. A 60-year-old man presented with scattered non-healing verrucous lesions as well as ulcers and excoriations on the upper extremities and trunk. The lesion had begun shortly after the patient was scratched by prickly okra. The patient ...
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#1Henry G. Skelton (Quest Diagnostics)H-Index: 45
#2W. Sun (Quest Diagnostics)
Last. Kathleen J. Smith (Quest Diagnostics)H-Index: 34
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Genetic identity analysis is a procedure that may be done on paraffin blocks to determine genetic identity or non-identity of tissues. On occasion biopsy specimens from different patients are mixed up. This becomes a major problem if the subsequent diagnoses require further therapy or have other significant medical implications. We recently had such a case in which three biopsy specimens from a middle age man were possibly mixed up with that from a pre-teen age boy. The biopsy from the pre-teen ...
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#1Kathleen J. Smith (Quest Diagnostics)H-Index: 34
#2Sate Hamza (UM: University of Manitoba)H-Index: 9
Last. Henry G. Skelton (Quest Diagnostics)H-Index: 45
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BACKGROUNDImiquimod (IMI) 5% is believed by some to result in an improved cosmetic appearance of chronically ultraviolet radiation (UV)-damaged skin.OBJECTIVEThe objective was to determine what histologic and immunohistologic changes were present in actinically damaged skin after treatment with IMI.
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#1Kathleen J. Smith (Quest Diagnostics)H-Index: 34
#2Henry G. Skelton (Quest Diagnostics)H-Index: 45
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#1Kathleen J. Smith (Quest Diagnostics)H-Index: 34
#2Henry G. Skelton (Quest Diagnostics)H-Index: 45
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#1Elizabeth Leef Jacobson (UAB: University of Alabama at Birmingham)H-Index: 7
#2Catherine R. Toms (UAB: University of Alabama at Birmingham)H-Index: 1
Last. Kathleen J. Smith (UAB: University of Alabama at Birmingham)H-Index: 34
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Although patients with neurofibromatosis (NF) have an increased incidence of tumors, there is only one study that suggests that NF1 patients may have an increased risk for epithelial malignancies. We present a patient with known NF1 who had developed multiple epithelial tumors since early in his life. All but one of these tumors were morphologically most consistent with trichoepitheliomas. Loss of heterozygosity (LOH) for Patched 1 gene (PTCH) was demonstrated within two of the trichoepitheloma-...
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