Alessandro Grattoni
Houston Methodist Hospital
Colloidal goldBiophysicsInternal medicineBiomedical engineeringControlled releaseNanotechnologyChemistryMaterials scienceIn vivoLewis lung carcinomaDrug deliveryDrugImplantTransplantationTenofovir alafenamideMembraneCancer researchSiliconMedicineCell biologyPharmacology
111Publications
24H-index
1,700Citations
Publications 114
Newest
#1Nicola Di Trani (CAS: Chinese Academy of Sciences)H-Index: 7
#2Hsuan-Chen Liu (Houston Methodist Hospital)
Last. Alessandro Grattoni (Houston Methodist Hospital)H-Index: 24
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Hypertension is a chronic condition that requires lifelong therapeutic management. Strict adherence to drug administration timing improves efficacy, while poor adherence leads to safety concerns. In light of these challenges, we present a nanofluidic technology that enables long-acting drug delivery with tunable timing of drug administration using buried gate electrodes in nanochannels. We developed a poly(ethylene glycol) methyl ether-block-poly(e-caprolactone) (PEG-PCL)-based micellar formulat...
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#1Hsuan Chen Liu (Houston Methodist Hospital)H-Index: 4
#2Dixita I. Viswanath (A&M: Texas A&M University)H-Index: 1
Last. Alessandro Grattoni (Houston Methodist Hospital)H-Index: 24
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Abstract Purpose Mounting evidence demonstrates that combining radiotherapy (RT) with immunotherapy can reduce tumor burden in a subset of patients. However, conventional systemic delivery of immunotherapeutics is often associated with significant adverse effects, which force treatment cessation. The aim of this study is to investigate a minimally invasive therapeutics delivery approach to improve clinical response while attenuating toxicity. Methods We utilized a nanofluidic drug-eluting seed (...
3 CitationsSource
#1Joseph W. RomanoH-Index: 20
#2Marc M. BaumH-Index: 23
Last. Doris ZaneH-Index: 4
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The ability to successfully develop a safe and effective vaccine for the prevention of HIV infection has proven challenging. Consequently, alternative approaches to HIV infection prevention have been pursued, and there have been a number of successes with differing levels of efficacy. Currently, only two oral pre-exposure prophylaxis (PrEP) products are available, Truvada and Descovy. Descovy is a newer product not yet indicated in individuals at risk of HIV-1 infection from receptive vaginal se...
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#1Fernanda P. Pons-Faudoa (Tec: Monterrey Institute of Technology and Higher Education)H-Index: 4
#2Antons Sizovs (Houston Methodist Hospital)H-Index: 12
Last. Sandra Demaria (Cornell University)H-Index: 67
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Pre-exposure prophylaxis (PrEP) using antiretroviral oral drugs is effective at preventing HIV transmission when individuals adhere to the dosing regimen. Tenofovir alafenamide (TAF) is a potent antiretroviral drug, with numerous long-acting (LA) delivery systems under development to improve PrEP adherence. However, none has undergone preventive efficacy assessment. Here we show that LA TAF using a novel subcutaneous nanofluidic implant (nTAF) confers partial protection from HIV transmission. We...
2 CitationsSource
#2Antons SizovsH-Index: 12
Last. Alessandro GrattoniH-Index: 24
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#1Corrine Ying Xuan Chua (Houston Methodist Hospital)H-Index: 12
#2Hsuan-Chen Liu (Houston Methodist Hospital)
Last. Alessandro Grattoni (Houston Methodist Hospital)H-Index: 24
view all 14 authors...
Abstract Carbon fibers reinforced polymers (CFRPs) are prolifically finding applications in the medical field, moving beyond the aerospace and automotive industries. Owing to its high strength-to-weight ratio, lightness and radiolucency, CFRP-based materials are emerging to replace traditional metal-based medical implants. Numerous types of polymers matrices can be incorporated with carbon fiber using various manufacturing methods, creating composites with distinct properties. Thus, prior to bio...
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#1Rossana Terracciano (Polytechnic University of Turin)H-Index: 3
#2Aobo Zhang (Rice University)H-Index: 2
Last. Carly S. Filgueira (Houston Methodist Hospital)H-Index: 11
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The heterogeneous distribution of delivery or treatment modalities within the tumor mass is a crucial limiting factor for a vast range of theranostic applications. Understanding the interactions between a nanomaterial and the tumor microenvironment will help to overcome challenges associated with tumor heterogeneity, as well as the clinical translation of nanotheranostic materials. This study aims to evaluate the influence of protein surface adsorption on gold nanoparticle (GNP) biodistribution ...
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#2E. Brian ButlerH-Index: 49
Last. Carly S. FilgueiraH-Index: 11
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#1Hsuan-Chen Liu (Houston Methodist Hospital)
#2Dixita I. Viswanath (Houston Methodist Hospital)H-Index: 1
Last. Alessandro Grattoni (Houston Methodist Hospital)H-Index: 24
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Background Pancreatic adenocarcinoma (PDAC) is associated with extremely poor prognosis and a 5-year survival rate of 10% and remains a lethal malignancy. Surgical resection and combination with chemoradiotherapy are the current standard-of-care options, may improve long-term survival in localized disease; however, the majority of patients are diagnosed at advanced stage. The incorporation of immunotherapy in the treatment algorithm convenes a new era for PDAC treatment. Several immunotherapy ap...
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#1Rossana Terracciano (Houston Methodist Hospital)H-Index: 3
#2Sara Ricchetti (Houston Methodist Hospital)H-Index: 1
Last. Carly S. Filgueira (Houston Methodist Hospital)H-Index: 11
view all 6 authors...
Lung cancer produces the highest number of cancer-related deaths worldwide. Currently, Non-Small Cell Lung Cancer (NSCLC) accounts for more than 85% of those cases. To date, achieving an early and precise diagnosis of NSCLC remains challenging due to extensive intratumor heterogeneity, which concerns not only to tumor epithelial cells but also the diverse microenvironment with which the tumor cells interact. In addition, genetic and phenotypic tumor heterogeneity and consequent non-uniform spati...
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