Matteo Santoni
Marche Polytechnic University
CancerInternal medicineSurgeryPathologyOncologyImmunologyChemotherapyRenal cell carcinomaCarcinomaImmunotherapyMetastasisSunitinibProstate cancerNephrectomyBladder cancerPopulationIn patientCancer researchClinical trialMedicineBiologyImmune systemCancer cell
439Publications
44H-index
5,133Citations
Publications 417
Newest
#1Alessandro RizzoH-Index: 14
#2Matteo SantoniH-Index: 44
Last. Francesco MassariH-Index: 41
view all 6 authors...
Prostate cancer remains the most frequently diagnosed non-skin malignancy in male patients, still representing one of the main causes of cancer-related death worldwide. Evidence is mounting that suggests the putative role of microbiota in the carcinogenesis as well as in modulating the efficacy and activity of anticancer treatments (e.g., chemotherapy, immune checkpoint inhibitors, targeted therapies) in a large number of hematological and solid tumors. However, few data are available regarding ...
Source
#1Sara Elena RebuzziH-Index: 8
#2Alessio SignoriH-Index: 28
Last. Giacomo CartenìH-Index: 39
view all 20 authors...
Source
Background: With hormonal agents quickly expanding as novel therapeutic options in nonmetastatic castration-resistant prostate cancer (nmCRPC), the toxicity profile of enzalutamide, apalutamide, an...
Source
#1Matteo SantoniH-Index: 44
#2Roberto Iacovelli (Agostino Gemelli University Polyclinic)H-Index: 32
Last. Marianna Nuti (Sapienza University of Rome)H-Index: 24
view all 6 authors...
Introduction null Altered receptor tyrosine kinase (RTK) signaling contributes to tumorigenesis and suppression of immune-mediated destruction of cancer cells. Cabozantinib is an oral tyrosine kinase inhibitor that inhibits several RTKs involved in tumorigenesis, and is approved for the treatment of patients with progressive metastatic medullary thyroid cancer, advanced renal cell carcinoma, and hepatocellular carcinoma that has been previously treated with sorafenib. null Areas covered null We ...
Source
Introduction: In the evolving treatment scenario of metastatic renal cell carcinoma, cabozantinib is gaining increasing attention, presenting as a cornerstone therapy, both as a monotherapy and in combination with immune-checkpoint inhibitors.Areas covered: In this review, the authors explore the role of cabozantinib in the treatment of metastatic clear cell and non-clear cell renal cell carcinoma, presenting data from the most recent clinical trials and investigating ongoing studies. They, furt...
Source
#1Alessandro Rizzo (Casa Sollievo della Sofferenza)
#2Marco OderdaH-Index: 21
Last. Francesco MassariH-Index: 41
view all 10 authors...
Several novel androgen receptor (AR)-inhibitors have been introduced for nonmetastatic castration-resistant prostate cancer (nmCRPC) treatment, with the improvement of survival outcomes which need to be balanced against the risk of adverse events. We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) investigating enzalutamide, apalutamide and darolutamide in nmCRPC patients, to assess overall survival (OS), incidence and risk of adverse drug events, adverse-e...
Source
#1Giorgio Santoni (University of Camerino)H-Index: 41
#2Massimo Nabissi (University of Camerino)H-Index: 32
Last. Maria Beatrice Morelli (University of Camerino)H-Index: 26
view all 8 authors...
The identification of cancer stem cells in brain tumors paved the way for new therapeutic approaches. Recently, a role for the transcriptional factor Runx1/Aml1 and the downstream ion channel genes in brain cancer development and progression has been suggested. This study aimed to explore the expression and the role of Runx1/Aml1, its Aml1b and Aml1c splice variants and the downstream TRPA1 and TRPV1 ion channels in undifferentiated and day-14 differentiated neural stem cells (NSCs and D-NSCs) a...
Source
#1Matteo SantoniH-Index: 44
#2Francesco MassariH-Index: 41
Last. Roberto Iacovelli (Agostino Gemelli University Polyclinic)H-Index: 32
view all 21 authors...
BACKGROUND Renal cell carcinoma with sarcomatoid differentiation is a highly aggressive form of kidney cancer. OBJECTIVE We aimed to analyze the outcomes of patients treated with cabozantinib for metastatic renal cell carcinoma with sarcomatoid features. METHODS We retrospectively collected data from 16 worldwide centers. Overall survival and progression-free survival were analyzed using Kaplan-Meier curves. Cox proportional models were used for univariate and multivariate analyses. RESULTS We c...
Source
#1Giorgio Santoni (University of Camerino)H-Index: 41
#2Consuelo Amantini (University of Camerino)H-Index: 33
Last. Angela Santoni (Sapienza University of Rome)H-Index: 84
view all 6 authors...
Natural killer (NK) cells are a main subset of innate lymphocytes that contribute to host immune protection against viruses and tumors by mediating target cell killing and secreting a wide array of cytokines. Their functions are finely regulated by a balance between activating and inhibitory receptors and involve also adhesive interactions. Mechanotransduction is the process in which physical forces sensed by mechanosensors are translated into chemical signaling. Herein, we report findings on th...
Source
#1Veronica MollicaH-Index: 13
#2Stefano BrocchiH-Index: 7
Last. Francesco MassariH-Index: 41
view all 11 authors...
Treatment response is usually assessed by the response evaluation criteria in solid tumors (RECIST). These criteria may not be adequate to evaluate the response to immunotherapy, considering the peculiar patterns of response reported with this therapy. With the advent of immunotherapy these criteria have been modified to include the evaluation of the peculiar responses seen with this type of therapy (iRECIST criteria), including pseudoprogressions and hyperprogressions. Tumor growth rate (TGR) i...
Source