Olav B. Smeland
Oslo University Hospital
Genome-wide association studyPsychiatryPhenotypeBrain morphometrySingle-nucleotide polymorphismPsychologyHeritabilityNeuroscienceCognitionGenetic associationFalse discovery rateBipolar disorderLinkage disequilibriumGeneticsGenetic correlationComputational biologyMedicineSchizophreniaBiologyGenetic architecture
Publications 105
#1Florian Krull (University of Oslo)H-Index: 10
#2Ibrahim A Akkouh (Oslo University Hospital)H-Index: 3
Last. Nils Eiel Steen (Oslo University Hospital)H-Index: 22
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Lithium is the first-line treatment for bipolar disorder (BD), but there is a large variation in response rate and adverse effects. Although the molecular effects of lithium have been studied extensively, the specific mechanisms of action remain unclear. In particular, the molecular changes underlying lithium adverse effects are little known. Multiple linear regression analyses of lithium serum concentrations and global gene expression levels in whole blood were carried out using a large case-co...
#1Janos KalmanH-Index: 9
Last. Tim B. BigdeliH-Index: 25
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#1Linn Rødevand (Oslo University Hospital)H-Index: 6
#2Shahram Bahrami (Oslo University Hospital)H-Index: 9
Last. Srdjan Djurovic (University of Bergen)H-Index: 77
view all 14 authors...
Patients with bipolar disorder (BIP) have a high risk of cardiovascular disease (CVD), despite considerable individual variation. The mechanisms underlying comorbid CVD in BIP remain largely unknown. We investigated polygenic overlap between BIP and CVD phenotypes, including CVD risk factors and coronary artery disease (CAD). We analyzed large genome-wide association studies of BIP (n = 51,710) and CVD phenotypes (n = 159,208-795,640), using bivariate causal mixture model (MiXeR), which estimate...
#1Guy Hindley ('KCL': King's College London)H-Index: 4
#2Kevin O'Connell (Oslo University Hospital)H-Index: 12
Last. Aihua Lin (Oslo University Hospital)H-Index: 1
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Mood instability (MOOD) is a transdiagnostic phenomenon with a prominent neurobiological basis. Recent genome-wide association studies found significant positive genetic correlation between MOOD and major depression (DEP) and weak correlations with other psychiatric disorders. We investigated the polygenic overlap between MOOD and psychiatric disorders beyond genetic correlation to better characterize putative shared genetic determinants. Summary statistics for schizophrenia (SCZ, n=105,318), bi...
#1Shahram Bahrami (Oslo University Hospital)H-Index: 9
#2Guy Hindley (Oslo University Hospital)H-Index: 4
Last. Ketil Joachim Ødegaard (Haukeland University Hospital)H-Index: 3
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Migraine is three times more prevalent in people with bipolar disorder or depression. The relationship between schizophrenia and migraine is less certain although glutamatergic and serotonergic neurotransmission are implicated in both. A shared genetic basis to migraine and mental disorders has been suggested but previous studies have reported weak or non-significant genetic correlations and five shared risk loci. Using the largest samples to date and novel statistical tools, we aimed to determi...
#1Kevin O'Connell (Oslo University Hospital)H-Index: 12
#2Oleksandr Frei (Oslo University Hospital)H-Index: 19
Last. Alexey A. Shadrin (Oslo University Hospital)H-Index: 12
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ABSTRACT null null Background null A range of sleep disturbances are commonly experienced by patients with psychiatric disorders, and genome-wide genetic analyses have shown some significant genetic correlations between these traits. Here we applied novel statistical genetic methodologies to better characterize the potential shared genetic architecture between sleep-related phenotypes and psychiatric disorders. null null null Methods null Utilizing the MiXeR method, that can estimate polygenic o...
#1Monereo-Sánchez J (UM: Maastricht University)
#2Miranda T. Schram (UM: Maastricht University)H-Index: 40
Last. David Edmund Johannes Linden (UM: Maastricht University)H-Index: 79
view all 11 authors...
Background: Alzheimer's disease (AD) and depression are debilitating brain disorders that are often comorbid. Shared brain mechanisms have been implicated, yet findings are inconsistent, reflecting the complexity of the underlying pathophysiology. As both disorders are (partly) heritable, characterising their genetic overlap may provide aetiological clues. While previous studies have indicated negligible genetic correlations, this study aims to expose the genetic overlap that may remain hidden d...
#1Weiqiu Cheng (Oslo University Hospital)H-Index: 1
#2Oleksandr Frei (Oslo University Hospital)H-Index: 19
Last. Guy Hindley ('KCL': King's College London)H-Index: 4
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Importance null Schizophrenia is a complex heritable disorder associated with many genetic variants, each with a small effect. While cortical differences between patients with schizophrenia and healthy controls are consistently reported, the underlying molecular mechanisms remain elusive. null Objective null To investigate the extent of shared genetic architecture between schizophrenia and brain cortical surface area (SA) and thickness (TH) and to identify shared genomic loci. null Design, setti...
#1Kristin Torgersen (University of Oslo)
#2Shahram Bahrami (Oslo University Hospital)H-Index: 9
Last. Ole A. Andreassen (Oslo University Hospital)H-Index: 123
view all 10 authors...
Neuroticism is associated with poor health, cardiovascular disease (CVD) risk factors and coronary artery disease (CAD). The conditional/conjunctional false discovery rate method (cond/conjFDR) was applied to genome wide association study (GWAS) summary statistics on neuroticism (n = 432,109), CAD (n = 184,305) and 12 CVD risk factors (n = 188,577-339,224) to investigate genetic overlap between neuroticism and CAD and CVD risk factors. CondFDR analyses identified 729 genomic loci associated with...