David Kalfert
First Faculty of Medicine, Charles University in Prague
OtorhinolaryngologyCancerRadiologyEtiologySurgeryPathologyOncologyCellImmunohistochemistryFine-needle aspirationHead and neck cancerHead and neck squamous-cell carcinomaMiddle earParanasal sinusesMetastasisMalignancyParotid glandCancer researchThyroidMedicine
38Publications
8H-index
218Citations
Publications 38
Newest
#1Ivana KholováH-Index: 9
#2David Kalfert (First Faculty of Medicine, Charles University in Prague)H-Index: 8
Last. Marie Ludvíková (Charles University in Prague)H-Index: 15
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Follicular epithelial dysplasia (FED) is described as Hashimoto thyroiditis-related atypia and is thought to be a possible precancerous lesion. Dysplasia as an interface between normal state and carcinoma is described in a wide range of diseases and carcinogenesis chains. On the other hand, inflammation-related atypia and cancerogenesis is also widely studied. In this study, we retrospectively analyzed 91 specimens of thyroid gland surgical resections with FED during a 10-year-period at the univ...
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#1Anna Švejdová (Charles University in Prague)
#2David Kalfert (First Faculty of Medicine, Charles University in Prague)H-Index: 8
Last. Viktor Chrobok (Charles University in Prague)H-Index: 8
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OBJECTIVE Oncocytic papillary cystadenomas (OPCs) of the larynx are rare benign cystic lesions that usually present as supraglottic masses arising from the laryngeal ventricles. OPCs are found in patients older than 60 years, with a female predominance. Symptoms vary from asymptomatic to hoarseness, dyspnea, and dysphagia; often, they mimic a laryngocele. The treatment is surgical. Diagnosis is based on histopathologic examination. MATERIALS AND METHODS Surgical records for laryngeal masses diag...
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Background: Acute acoustic trauma (AAT) ranks, among others, as one common cause of inner ear function impairment, especially in terms of military personnel, who are at an increased exposure to impulse noises from firearms. Aim of this study: 1. We wanted to demonstrate whether early treatment of AAT means a higher chance for the patient to improve hearing after trauma. 2. We find the answer to the question of whether hyperbaric oxygen therapy (HBO2) has a positive effect in the treatment of AAT...
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#1Mikk Abram (UTA: University of Tampere)H-Index: 1
#2Roope Huhtamella (UTA: University of Tampere)H-Index: 1
Last. Ivana Kholová (UTA: University of Tampere)H-Index: 9
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INTRODUCTION Thyroid cytology is a widely accepted tool in the clinical triaging of nodular lesions. Cell blocks (CBs) can help in the diagnosis of atypical lesions, namely, thyroid Bethesda category of Atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS). METHODS In a series of 224 AUS/FLUS thyroid samples with CB, we studied CB cellularity and feasibility of 3 immunohistochemical markers (cytokeratin 19 [CK19], HBME-1, and galectin-3) apart and in combi...
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Fabry disease (FD) is a lysosomal storage disorder caused by pathogenic mutations in the alpha-galactosidase A (AGALA) encoding gene region. This rare disease affects several organs including the cochlea-vestibular system. Tinnitus and sensorineural hearing loss (SNHL) are reported among otoneurological symptoms. Early and correct diagnosis of FD is important with a view to available therapy. The aim of the study was to screen for alpha-galactosidase deficiency in men with tinnitus/SNHL. A prosp...
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Cancer-associated fibroblasts (CAFs) are one of the most abundant and critical components of the tumor stroma. CAFs can impact many important steps of cancerogenesis and may also influence treatment resistance. Some of these effects need the direct contact of CAFs and cancer cells, while some involve paracrine signals. In this study, we investigated the ability of head and neck squamous cell carcinomas (HNSCC) patient-derived CAFs to promote or inhibit the colony-forming ability of HNSCC cells. ...
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#1Jarkko LintusaariH-Index: 1
#2Eini VesaniemiH-Index: 1
Last. Ivana KholováH-Index: 9
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IgG4-positive plasma cells in Hashimoto thyroiditis: IgG4-related disease or inflammation-related IgG4-positivity? Despite the interest of researchers in IgG4-related disease (IgG4-RD), many questions still remain unanswered regarding the thyroid gland. We aimed to clarify the relationship between IgG4-positive plasma cells and the histopathological pattern in the Hashimoto thyroiditis (HT) in a Finnish series. HT specimens (n=280) were retrieved from the Department of Pathology, Fimlab Laborato...
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#1Lucie Dostalova (First Faculty of Medicine, Charles University in Prague)H-Index: 2
#2David Kalfert (First Faculty of Medicine, Charles University in Prague)H-Index: 8
Last. Jan Plzak (First Faculty of Medicine, Charles University in Prague)H-Index: 19
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#1David Kalfert (Charles University in Prague)H-Index: 8
#2Marie Ludvíková (Charles University in Prague)H-Index: 15
Last. Ivana KholováH-Index: 9
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MiR-34a belongs to the class of small non-coding regulatory RNAs and functions as a tumor suppressor. Under physiological conditions, miR-34a has an inhibitory effect on all processes related to cell proliferation by targeting many proto-oncogenes and silencing them on the post-transcriptional level. However, deregulation of miR-34a was shown to play important roles in tumorigenesis and processes associated with cancer progression, such as tumor-associated epithelial-mesenchymal transition, inva...
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#1Vladimir Koucky (First Faculty of Medicine, Charles University in Prague)H-Index: 2
#2David Kalfert (First Faculty of Medicine, Charles University in Prague)H-Index: 8
Last. Jan PlzakH-Index: 19
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Background: Low-grade fibromyxoid sarcoma (LGFMS) is a rare malignant tumor. Moreover, only 3 cases of LGFMS originating from the nasal cavity and/or paranasal sinuses have been published so far. Methods: Two patients with histologically confirmed LGFMS of the maxillary sinus were primarily treated by open and endoscopic surgery. In one case adjuvant radiotherapy was indicated because of the uncertainty of the surgical margins. Results: Both surgeries were technically demanding and accompanied b...
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