Marcel Kool
German Cancer Research Center
GeneCancerInternal medicineWnt signaling pathwayPathologyOncologyMolecular biologyTranscriptomeGene expression profilingDNA methylationBrain tumorMedulloblastomaEpendymomaEpigeneticsCancer researchGeneticsCarcinogenesisBioinformaticsComputational biologyText miningMedicineBiology
Publications 477
#1Matthew D. Young (Wellcome Trust Sanger Institute)H-Index: 22
#2Thomas J. Mitchell (Wellcome Trust Sanger Institute)H-Index: 21
Last. Ronald R. de Krijger (UU: Utrecht University)H-Index: 52
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Tumor cells may share some patterns of gene expression with their cell of origin, providing clues into the differentiation state and origin of cancer. Here, we study the differentiation state and cellular origin of 1300 childhood and adult kidney tumors. Using single cell mRNA reference maps of normal tissues, we quantify reference "cellular signals" in each tumor. Quantifying global differentiation, we find that childhood tumors exhibit fetal cellular signals, replacing the presumption of "feta...
#1Felix Schmitt-Hoffner (Heidelberg University)
#2Sjoerd van Rijn (DKFZ: German Cancer Research Center)H-Index: 2
Last. Stefan M. Pfister (DKFZ: German Cancer Research Center)H-Index: 116
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PURPOSEClinical outcomes of patients with neuroblastoma range from spontaneous tumor regression to fatality. Hence, understanding the mechanisms that cause tumor progression is crucial for the trea...
#1Katja von Hoff (Charité)H-Index: 29
#2Christine Haberler (Medical University of Vienna)H-Index: 29
Last. Marcel KoolH-Index: 92
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BACKGROUND Only few data are available on treatment-associated behavior of distinct rare CNS-embryonal tumor entities previously treated as "CNS-primitive neuroectodermal tumors" (CNS-PNET). Respective data on specific entities, including CNS neuroblastoma, FOXR2 activated (CNS NB-FOXR2), and embryonal tumor with multi-layered rosettes (ETMR) are needed for development of differentiated treatment strategies. METHODS Within this retrospective, international study, tumor samples of clinically well...
#8Charlotte Gatzweiler (DKFZ: German Cancer Research Center)
#2Arash Nabbi (Princess Margaret Cancer Centre)H-Index: 2
#1Milena Simovic (DKFZ: German Cancer Research Center)H-Index: 2
#1Milena Simovic (DKFZ: German Cancer Research Center)H-Index: 1
Last. Aurélie Ernst (DKFZ: German Cancer Research Center)H-Index: 16
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BACKGROUND Medulloblastomas with chromothripsis developing in children with Li-Fraumeni Syndrome (germline TP53 mutations) are highly aggressive brain tumors with dismal prognosis. Conventional photon radiotherapy and DNA-damaging chemotherapy are not successful for these patients and raise the risk of secondary malignancies. We hypothesized that the pronounced homologous recombination deficiency in these tumors might offer vulnerabilities that can be therapeutically utilized in combination with...
#1Daniela Lötsch (Medical University of Vienna)H-Index: 16
#2Dominik Kirchhofer (Medical University of Vienna)H-Index: 4
Last. Johannes Gojo (Medical University of Vienna)H-Index: 13
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Ependymomas (EPN) are central nervous system tumors comprising both aggressive and more benign molecular subtypes. However, therapy of the high-risk subtypes posterior fossa group A (PF-A) and supratentorial RELA-fusion positive (ST-RELA) is limited to gross total resection and radiotherapy, as effective systemic treatment concepts are still lacking. We have recently described fibroblast growth factor receptors 1 and 3 (FGFR1/FGFR3) as oncogenic drivers of EPN. However, the underlying molecular ...