Federica Palorini
Vita-Salute San Raffaele University
Internal medicineRadiologyUrologySurgeryOncologyProspective cohort studyCohort studyProstateFecal incontinenceProstate cancerPopulationUrinary symptomsToxicityRadical radiotherapyIn patientIncidence (epidemiology)Radiation therapyMedicineCohortUrinary system
58Publications
11H-index
222Citations
Publications 57
Newest
#1Alessandro Cicchetti (UNIPV: University of Pavia)H-Index: 7
#2Barbara AvuzziH-Index: 11
Last. Riccardo Valdagni (University of Milan)H-Index: 51
view all 13 authors...
Purpose This study aimed to validate a previously published predictive model for late fecal incontinence (FI) in a contemporary population of prostate cancer patients treated with radical radiation therapy. Methods and Materials The validation included patients treated with intensity-modulated radiation therapy (IMRT) (2010-2014). Prescribed dose range was 65-80 Gy, including conventional and moderate hypo-fractionated treatments. Rectal toxicity was scored using LENT/SOMA, a minimum 2-year foll...
7 CitationsSource
#1Elisa ScalcoH-Index: 11
#2Tiziana RancatiH-Index: 27
Last. Giovanna RizzoH-Index: 34
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PURPOSE: To investigate the potential of texture analysis applied on T2-w and postcontrast T1-w images acquired before radiotherapy for prostate cancer (PCa) and 12 months after its completion in quantitatively characterizing local radiation effect on the muscular component of internal obturators, as organs potentially involved in urinary toxicity. METHODS: T2-w and postcontrast T1-w MR images were acquired at 1.5 T before treatment (MRI1) and at 12 months of follow-up (MRI2) in 13 patients trea...
4 CitationsSource
#2Tiziana RancatiH-Index: 27
Last. R. ValdagniH-Index: 4
view all 16 authors...
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#1Federica PaloriniH-Index: 11
Last. C. FiorinoH-Index: 7
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61Background: Predictive models for late rectal bleeding (LRB) after radiotherapy (RT) for prostate cancer were established by several studies, with good performance on development population (POP). Nonetheless, they were found to be unsatisfactory in their generalization to independent validation cohorts. Aim of the study is to build a metamodel for grade 2-3 (G23) and grade 3 (G3) LRB (LENT/SOMA) starting from literature evidence and to validate it on a new POP. Methods: The metamodel was cons...
1 CitationsSource
#1N. BediniH-Index: 5
#2Alessandro Cicchetti (UNIPV: University of Pavia)H-Index: 7
Last. Riccardo Valdagni (University of Milan)H-Index: 51
view all 16 authors...
A recent “hot topic” in prostate cancer radiotherapy is the observed association between acute/late rectal toxicity and the presence of abdominal surgery before radiotherapy. The exact mechanism is unclear. Our working hypothesis was that a previous surgery may influence plasma level of inflammatory molecules and this might result in enhanced radiosensitivity. We here present results on the feasibility of monitoring the expression of inflammatory molecules during radiotherapy. Plasma levels of a...
7 CitationsSource
#2Tiziana RancatiH-Index: 27
Last. R. ValdagniH-Index: 4
view all 16 authors...
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#1Cesare CozzariniH-Index: 43
#2Tiziana RancatiH-Index: 27
Last. C. FiorinoH-Index: 7
view all 14 authors...
Abstract Background and purpose Urinary incontinence following radiotherapy (RT) for prostate cancer (PCa) has a relevant impact on patient’s quality of life. The aim of the study was to assess the unknown dose–effect relationship for late patient-reported urinary incontinence (LPRUI). Methods and materials Patients were enrolled within the multi-centric study DUE01. Clinical and dosimetry data including the prescribed 2 Gy equivalent dose (EQD2) were prospectively collected. LPRUI was evaluated...
12 CitationsSource