Valeria Paradies
University of Bari
BioenergeticsInternal medicineEndocrinologyMitochondrial permeability transition poreRenal functionCardiologyElectron transport chainOxidative stressMelatoninHeart failureReperfusion injuryPercutaneous coronary interventionCardiolipinMitochondrionRespiratory chainMyocardial infarctionBiochemistryMedicineInner mitochondrial membraneBiologyCell biology
Publications 39
Abstract null null Coronary microvascular dysfunction is a highly prevalent condition of both structural and functional coronary disorders in patients with angina and nonobstructive coronary artery disease (ANOCA). Current diagnostic modalities to assess microvascular function are related to prognosis, but these modalities have several technical shortcomings and lack the opportunity to determine true coronary blood flow and microvascular resistance. Intracoronary continuous thermodilution assess...
#1Heerajnarain Bulluck (UEA: University of East Anglia)H-Index: 1
#2Valeria ParadiesH-Index: 6
Last. Derek J. Hausenloy (UCL: University College London)H-Index: 97
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A substantial number of chronic coronary syndrome (CCS) patients undergoing percutaneous coronary intervention (PCI) experience periprocedural myocardial injury or infarction. Accurate diagnosis of these PCI-related complications is required to guide further management given that their occurrence may be associated with increased risk of major adverse cardiac events (MACE). Due to lack of scientific data, the cut-off thresholds of post-PCI cardiac troponin (cTn) elevation used for defining peripr...
2 CitationsSource
#1Rosanne F. Vogel (UU: Utrecht University)H-Index: 2
#2Ronak Delewi (UvA: University of Amsterdam)H-Index: 24
Last. Valeria ParadiesH-Index: 15
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Abstract null null Objectives null This study sought to compare the pharmacodynamic effects of pre-hospitally administered P2Y12 inhibitor prasugrel in crushed versus integral tablet formulation in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI). null null null Background null Early dual antiplatelet therapy is recommended in STEMI patients. Yet, onset of oral P2Y12 inhibitor effect is delayed and varies according to f...
1 CitationsSource
#1Valeria ParadiesH-Index: 15
#2Christoph WaldeyerH-Index: 12
Last. Pieter C. SmitsH-Index: 44
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A significant proportion of patients presenting with acute coronary syndromes (ACS) have multivessel disease (MVD). Despite the abundance of clinical trials in this area, several questions regarding the procedure of complete coronary revascularisation remain unanswered. This state-of-the-art review summarises the latest evidence on complete revascularisation (CR) in this subset of patients and critically appraises clinical decision making based on non-culprit lesion (NCL) assessment. Future area...
#1C K Jaryl Ng (NUS: National University of Singapore)
#2Valeria ParadiesH-Index: 6
Last. Hui Ying Ang (NUS: National University of Singapore)H-Index: 6
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Provisional stenting is considered the gold standard approach for most bifurcation lesions, but the benefit of routine side branch (SB) strut dilatation has not been fully elucidated. A benchtop model was used to determine the benefits of routine side branch (SB) dilatation techniques on strut apposition, acute thrombogenicity, and flow disruption. Three different provisional bifurcation techniques were compared: no SB dilatation "keep it open" method (KIO), sequential balloon dilatation (SBD), ...
Thermodilution-derived measurement of absolute coronary flow and resistance has been recently validated by using a dedicated microcatheter and a pressure-temperature guidewire. The relationship between standard functional assessment and absolute flow and resistance has never been investigated. 30
Abstract Background Drug eluting stents with biodegradable polymers have been developed to address the risk of very late adverse events. Long-term comparison data between the biodegradable polymer-coated biolimus-eluting stent (BES; Nobori®) and the second-generation durable polymer-coated everolimus-eluting stent (EES; XIENCE V® or XIENCE PRIME® or PROMUS™) in diabetic patients are scarce. Methods The COMPARE II trial was an investigator-initiated, multicenter, open-label, randomized, all-comer...
7 CitationsSource