Andrew J. Schork
Mental Health Services
Genome-wide association studyPsychiatryInternal medicineSNPDemographySingle-nucleotide polymorphismPsychologyHeritabilityGenetic associationFalse discovery rateDiseasePopulationGeneticsBioinformaticsMedicineCohortSchizophreniaLocus (genetics)BiologyGenetic architecture
Publications 111
#1Xueping Liu (Centre for Mental Health)H-Index: 1
#2Ron Nudel (CMHS: Mental Health Services)H-Index: 3
Last. Michael E. Benros (Centre for Mental Health)H-Index: 32
view all 15 authors...
1 CitationsSource
#1Esben Agerbo (Lundbeck)H-Index: 66
#2Betina B. Trabjerg (Lundbeck)H-Index: 9
Last. Katherine L. Musliner (Lundbeck)H-Index: 13
view all 18 authors...
Importance Combining information on polygenic risk scores (PRSs) with other known risk factors could potentially improve the identification of risk of depression in the general population. However, to our knowledge, no study has estimated the association of PRS with the absolute risk of depression, and few have examined combinations of the PRS and other important risk factors, including parental history of psychiatric disorders and socioeconomic status (SES), in the identification of depression ...
1 CitationsSource
#1Lene Aarøe (AU: Aarhus University)H-Index: 13
#2Vivek AppaduraiH-Index: 11
Last. Michael Bang Petersen (AU: Aarhus University)H-Index: 33
view all 14 authors...
Although the genetic influence on voter turnout is substantial (typically 40–50%), the underlying mechanisms remain unclear. Across the social sciences, research suggests that ‘resources for politics’ (as indexed notably by educational attainment and intelligence test performance) constitute a central cluster of factors that predict electoral participation. Educational attainment and intelligence test performance are heritable. This suggests that the genotypes that enhance these phenotypes could...
1 CitationsSource
#1Xueping Liu (Centre for Mental Health)H-Index: 6
#2Ron Nudel (Lundbeck)H-Index: 3
Last. Michael E. Benros (Centre for Mental Health)H-Index: 32
view all 15 authors...
Abstract Background Previous studies have indicated the bidirectionality between autoimmune and mental disorders. However, genetic studies underpinning the co-occurrence of the two disorders have been lacking. In this study, we examined the potential genetic contribution to the association between autoimmune and mental disorders and investigated the genetic basis of overall autoimmune disease. Methods We used diagnostic information from patients with seven autoimmune diseases and six mental diso...
6 CitationsSource
#1Jonas Bybjerg-Grauholm (SSI: Statens Serum Institut)H-Index: 30
#2C. B. Pedersen (AU: Aarhus University)H-Index: 2
Last. Preben Bo Mortensen (AU: Aarhus University)H-Index: 133
view all 17 authors...
Abstract The Lundbeck Foundation Integrative Psychiatric Research (iPSYCH) consortium has almost doubled its Danish population-based Case–Cohort sample (iPSYCH2012). The newly updated cohort, named iPSYCH2015, expands the study base with 56,233 samples, to a combined total of 141,265 samples. The cohort is nested within the Danish population born between 1981 and 2008 and is a Case-Cohort design including 50,615 population controls. We added more cases to the existing phenotypes identified with,...
3 CitationsSource
#1Annette ErlangsenH-Index: 28
#2Vivek Appadurai (Lundbeck)H-Index: 11
Last. Esben Agerbo (Lundbeck)H-Index: 66
view all 17 authors...
Family studies have shown an aggregation of suicidal behavior in families. Yet, molecular studies are needed to identify loci accounting for genetic heritability. We conducted a genome-wide association study and estimated single nucleotide polymorphisms (SNP) heritability for a suicide attempt. In a case-cohort study, national data on all individuals born in Denmark after 1981 and diagnosed with severe mental disorders prior to 2013 (n = 57,377) and individuals from the general population (n = 3...
43 CitationsSource
#1Laura Goetz (TGen: Translational Genomics Research Institute)
Last. Nicholas J. SchorkH-Index: 135
view all 10 authors...
Background: Polygenic risk scores (PRS) have been developed to predict individual cancer risk and their potential clinical utility is receiving a great deal of attention. However, the degree to which the predictive utility of individual cancer-specific PRS may be augmented or refined by the incorporation of other cancer PRS, non-cancer disease PRS, or the protective effects of health and longevity-associated variants, is largely unexplored. Methods: We constructed PRS for different cancers from ...
#1Veera M. Rajagopal (AU: Aarhus University)H-Index: 10
#2Andrea Ganna (UH: University of Helsinki)H-Index: 36
Last. Ditte Demontis (AU: Aarhus University)H-Index: 32
view all 26 authors...
Individuals with psychiatric disorders perform differently in school compared to the general population. Genetic factors contribute substantially to such differences. It is however unclear if differential performance is seen across all cognitive domains such as math and language. Here we report a genome-wide association study (GWAS) of school grades in 30,982 individuals (18,495 with and 12,487 without one or more of six major psychiatric disorders) and a replication study in 4,547 individuals. ...
5 CitationsSource
#1Dennis van der Meer (UM: Maastricht University)H-Index: 20
#2Ida E Sønderby (University of Oslo)H-Index: 14
Last. Ole A. Andreassen (Oslo University Hospital)H-Index: 123
view all 132 authors...
Importance Recurrent microdeletions and duplications in the genomic region 15q11.2 between breakpoints 1 (BP1) and 2 (BP2) are associated with neurodevelopmental disorders. These structural variants are present in 0.5% to 1.0% of the population, making 15q11.2 BP1-BP2 the site of the most prevalent known pathogenic copy number variation (CNV). It is unknown to what extent this CNV influences brain structure and affects cognitive abilities. Objective To determine the association of the 15q11.2 BP...
24 CitationsSource
#1Ron Nudel (Lundbeck)H-Index: 9
#2Vivek Appadurai (Lundbeck)H-Index: 11
Last. Michael E. Benros (Lundbeck)H-Index: 32
view all 14 authors...
Gastrointestinal infections can be life threatening, but not much is known about the host’s genetic contribution to susceptibility to gastrointestinal infections or the latter’s association with psychiatric disorders. We utilized iPSYCH, a genotyped population-based sample of individuals born between 1981 and 2005 comprising 65,534 unrelated Danish individuals (45,889 diagnosed with mental disorders and 19,645 controls from a random population sample) in which all individuals were linked utilizi...
1 CitationsSource