Isabella Castellano
University of Turin
CancerInternal medicineRadiologyEndocrinologySurgeryPathologyOncologySentinel nodeImmunohistochemistryBiopsyCarcinomaMetastasisMalignancySentinel lymph nodeLymph nodeCancer researchBreast cancerMedicineEstrogen receptorBiology
Publications 144
#1Valeria Bitonto (UNITO: University of Turin)H-Index: 6
#2Maria Rosaria Ruggiero (UNITO: University of Turin)H-Index: 5
Last. Simonetta Geninatti Crich (UNITO: University of Turin)H-Index: 29
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As conserving surgery is routinely applied for the treatment of early-stage breast cancer, the need for new technology to improve intraoperative margin assessment has become increasingly important. In this study, the potential of fast field-cycling 1H-NMR relaxometry as a new diagnostic tool was evaluated. The technique allows the determination of the tissue proton relaxation rates (R1), as a function of the applied magnetic field, which are affected by the changes in the composition of the mamm...
#1Emad A. Rakha (NUH: Nottingham University Hospitals NHS Trust)H-Index: 75
#2Edi Brogi (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 61
Last. Cecily Quinn (UCD: University College Dublin)H-Index: 28
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Spindle cell lesions of the breast comprise a heterogeneous group of lesions, ranging from reactive and benign processes to aggressive malignant tumours. Despite their rarity, they attract the attention of breast pathologists due to their overlapping morphological features and diagnostic challenges, particularly on core needle biopsy (CNB) specimens. Pathologists should recognise the wide range of differential diagnoses and be familiar with the diverse morphological appearances of these lesions ...
#1Jasna Metovic (UNITO: University of Turin)H-Index: 7
#2Isabella Castellano (UNITO: University of Turin)H-Index: 27
Last. Mauro Papotti (UNITO: University of Turin)H-Index: 98
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According to the 2019 WHO classification of breast tumors, neuroendocrine neoplasms (NENs) are classified into well-differentiated NE tumors (NET) and poorly differentiated NE carcinomas (NEC), while other breast cancers (BCs) of special and no special type with neuroendocrine (NE) features are not incorporated in this scheme anymore. We aimed to assess whether INSM1, a novel NE marker, could have a role in breast NEN subtyping. We selected 63 BCs operated from 2003 to 2018, classified as BCs wi...
#1Bruno MeduriH-Index: 9
#2Fiorenza De RoseH-Index: 15
Last. A. CiabattoniH-Index: 8
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The multidisciplinary management represents a crucial part of the care for cancer patients, resulting in better clinical and process outcomes, with evidence of improved survival among different cancer primary sites, including breast. According with international recommendations established by the European Society of Breast Cancer Specialists (EUSOMA), all breast-cancer patients have to be evaluated by a multidisciplinary team including radiologist, pathologist, surgeon, medical oncologist and ra...
#1Jasna Metovic (UNITO: University of Turin)H-Index: 7
#2Simona Osella Abate (UNITO: University of Turin)H-Index: 4
Last. Isabella Castellano (UNITO: University of Turin)H-Index: 27
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Background Many oncologists debate if lobular neoplasia (LN) is a risk factor or an obligatory precursor of more aggressive disease. This study has three aims: (i) describe the different treatment options (surgical resection vs observation), (ii) investigate the upgrade rate in surgically treated patients, and (iii) evaluate the long-term occurrences of aggressive disease in both operated and unoperated patients. Methods A series of 122 patients with LN bioptic diagnosis and follow-up informatio...
#2Isabella CastellanoH-Index: 27
Last. Fabrizio MalanH-Index: 1
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#1Jasna Metovic (UNITO: University of Turin)H-Index: 7
#2Alberto Bragoni (UNITO: University of Turin)
Last. Isabella Castellano (UNITO: University of Turin)H-Index: 27
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Background: Tubular Carcinoma (TC) is a low proliferative grade 1 (G1) breast cancer (BC). Despite its favorable outcome and allegedly lower aggressiveness, patients are treated like other luminal G1 BC, with radiotherapy (RT) and hormonal therapy (HT). We performed: (1) a retrospective study comparing a TC cohort and a control series of luminal G1 BC; (2) a systematic review and meta-analysis focused on TC outcome. Materials and methods: We selected a series of 572 G1 luminal BC (111 TC, 350 no...
#1Tracy Ann Williams (LMU: Ludwig Maximilian University of Munich)H-Index: 38
#2Celso E. Gomez-Sanchez (UMMC: University of Mississippi Medical Center)H-Index: 79
Last. Martin Reincke (LMU: Ludwig Maximilian University of Munich)H-Index: 82
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OBJECTIVE Develop a consensus for the nomenclature and definition of adrenal histopathologic features in unilateral primary aldosteronism (PA). CONTEXT Unilateral PA is the most common surgically-treated form of hypertension. Morphologic examination combined with CYP11B2 (aldosterone synthase) immunostaining reveals diverse histopathologic features of lesions in the resected adrenals. PATIENTS AND METHODS Surgically removed adrenals (n= 37) from 90 patients operated from 2015 to 2018 in Munich, ...
15 CitationsSource
#1Simona Osella-Abate (UNITO: University of Turin)H-Index: 26
#2Chiara Vignale (UNITO: University of Turin)H-Index: 2
Last. Simone Ribero (UNITO: University of Turin)H-Index: 24
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Specific subsets of T-helper lymphocytes have been identified as associated with anergy and impairment of CD8+ immune response against cancer cells. In particular, the immune infiltrate of regressed melanoma has been proven to have lower counts of CD25+/CD4+, FOXP3+/CD4+ and PD1+/CD4+ lymphocytes compared to the non-regressed ones.
3 CitationsSource
#1Fulvio Borella (UNITO: University of Turin)H-Index: 7
#2Mario Preti (UNITO: University of Turin)H-Index: 20
Last. Leonardo Micheletti (UNITO: University of Turin)H-Index: 16
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Vulvar cancer (VC) is a rare neoplasm, usually arising in postmenopausal women, although human papilloma virus (HPV)-associated VC usually develop in younger women. Incidences of VCs are rising in many countries. Surgery is the cornerstone of early-stage VC management, whereas therapies for advanced VC are multimodal and not standardized, combining chemotherapy and radiotherapy to avoid exenterative surgery. Randomized controlled trials (RCTs) are scarce due to the rarity of the disease and prog...
3 CitationsSource