Alistair Mathie
Medway School of Pharmacy
BiophysicsEndocrinologyPatch clampNeuroscienceReceptorMembrane potentialElectrophysiologyChemistryMuscarinic acetylcholine receptorVoltage-gated ion channelDepolarizationIon channelPotassiumCalciumBiochemistryMedicinePotassium channelBiologyCell biologyPharmacology
Publications 156
#1Alistair Mathie (Medway School of Pharmacy)H-Index: 43
#2Emma L. Veale (Medway School of Pharmacy)H-Index: 26
Last. Paul D. WrightH-Index: 6
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Two-pore domain potassium (K2P) channels stabilize the resting membrane potential of both excitable and nonexcitable cells and, as such, are important regulators of cell activity. There are many conditions where pharmacological regulation of K2P channel activity would be of therapeutic benefit, including, but not limited to, atrial fibrillation, respiratory depression, pulmonary hypertension, neuropathic pain, migraine, depression, and some forms of cancer. Up until now, few if any selective pha...
2 CitationsSource
#1Alistair Mathie (Medway School of Pharmacy)H-Index: 43
#2Emma L. Veale (Medway School of Pharmacy)H-Index: 26
Last. Robyn G. Holden (Medway School of Pharmacy)H-Index: 2
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#1Tatjana Lalic (University of Oxford)H-Index: 6
#2Aiste Steponenaite (Medway School of Pharmacy)H-Index: 1
Last. M. Zameel Cader (University of Oxford)H-Index: 15
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The suprachiasmatic nucleus (SCN) is a complex structure dependent upon multiple mechanisms to ensure rhythmic electrical activity that varies between day and night, to determine circadian adaptation and behaviours. SCN neurons are exposed to glutamate from multiple sources including from the retino-hypothalamic tract and from astrocytes. However, the mechanism preventing inappropriate post-synaptic glutamatergic effects is unexplored and unknown. Unexpectedly we discovered that TRESK, a calcium...
1 CitationsSource
#1Aiste Steponenaite (Medway School of Pharmacy)H-Index: 1
#2Tatjana Lalic (University of Oxford)H-Index: 6
Last. Gurprit S. Lall (UKC: University of Kent)H-Index: 15
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The suprachiasmatic nucleus (SCN), the mammalian circadian clock, is a heterogenous structure made of several neuron types that generate a circadian electrical activity profile. However, it is unclear how such regulation in endogenous neuronal excitability is maintained. Background two-pore domain potassium channels (K2P), such as TASK-3, play an important role in inhibiting neuronal activity. Here, we utilize a TASK-3 KO mouse model to unravel the role played by this channel in SCN circadian ne...
#1Vilius Savickas (Medway School of Pharmacy)H-Index: 3
#2Adrian J StewartH-Index: 2
Last. Emma L. Veale (Medway School of Pharmacy)H-Index: 26
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Background: Growing prevalence of atrial fibrillation (AF) in the ageing population, and its associated life-changing health and resource implications, have led to a need to improve its early detection. Primary care is an ideal place to screen for AF, however this is limited by shortages in general practitioner (GP) resources. Recent increases in the number of clinical pharmacists within primary care, makes them ideally placed to conduct AF screening. This study aimed to determine the feasibilit...
#1Vilius Savickas (Medway School of Pharmacy)H-Index: 3
#2Emma L. Veale (Medway School of Pharmacy)H-Index: 26
Last. Sarah A. Corlett (Medway School of Pharmacy)H-Index: 6
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Background Atrial fibrillation (AF) affects up to 10% of people aged ≥65 years, yet a third of all cases remain undetected. Practice-based pharmacists are in an ideal position to facilitate opportunistic AF screening, while increasing general practice capacity at a time of workforce crisis. Aim To explore the perspectives of three stakeholder groups involved in the ‘Pharmacists Detecting Atrial Fibrillation’ (PDAF) study to elucidate the facilitators and barriers to pharmacist-led AF screening i...
#1K P Cunningham (Medway School of Pharmacy)H-Index: 1
#1Kevin P. Cunningham (Medway School of Pharmacy)H-Index: 2
Last. Emma L. Veale (Medway School of Pharmacy)H-Index: 26
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AIMS The mode of action by which doxapram acts as a respiratory stimulant in humans is controversial. Studies in rodent models, have shown that doxapram is a more potent and selective inhibitor of TASK-1 and TASK-1/TASK-3 heterodimer channels, than TASK-3. Here we investigate the direct effect of doxapram and chirally separated, individual positive and negative enantiomers of the compound, on both human and mouse, homodimeric and heterodimeric variants of TASK-1 and TASK-3. METHODS Whole-cell pa...
6 CitationsSource
#2Eamonn KellyH-Index: 43
Last. Jamie A. DaviesH-Index: 54
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#1Stephen P.H. Alexander (University of Nottingham)H-Index: 56
#2John A. Cidlowski (NIH: National Institutes of Health)H-Index: 99
Last. Jamie A. Davies (Edin.: University of Edinburgh)H-Index: 54
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The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (, which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 ...
74 CitationsSource
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