Lisa T. Eyler
University of California, San Diego
PsychiatryInternal medicineDevelopmental psychologyPsychologyHeritabilityTwin studyNeuroscienceCognitionAutismBipolar disorderDepression (differential diagnoses)Functional magnetic resonance imagingMoodWhite matterBrain mappingAudiologyNeuroimagingClinical psychologyMedicineSchizophreniaBiology
Publications 198
#1Christopher R.K. Ching (SC: University of Southern California)H-Index: 25
#2Derrek P Hibar (Genentech)H-Index: 9
Last. Ole A. Andreassen (University of Oslo)H-Index: 123
view all 116 authors...
MRI-derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis-driven studies of BD. Through this e...
4 CitationsSource
#1Julie Loebach Wetherell (UCSD: University of California, San Diego)H-Index: 55
#2Hayley S Ripperger (WashU: Washington University in St. Louis)
Last. Eric J. Lenze (WashU: Washington University in St. Louis)H-Index: 61
view all 28 authors...
BACKGROUND/AIMS Age-related cognitive decline is a pervasive problem in our aging population. To date, no pharmacological treatments to halt or reverse cognitive decline are available. Behavioral interventions, such as physical exercise and Mindfulness-Based Stress Reduction, may reduce or reverse cognitive decline, but rigorously designed randomized controlled trials are needed to test the efficacy of such interventions. METHODS Here, we describe the design of the Mindfulness, Education, and Ex...
#1Paul M. Thompson (SC: University of Southern California)H-Index: 201
#2Neda Jahanshad (SC: University of Southern California)H-Index: 57
Last. Vladimir Zelman (SC: University of Southern California)H-Index: 23
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This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in ...
93 CitationsSource
#1Jared W. Young (UCSD: University of California, San Diego)H-Index: 50
#2Mark A. Geyer (UCSD: University of California, San Diego)H-Index: 135
Last. Lisa T. Eyler (UCSD: University of California, San Diego)H-Index: 47
view all 8 authors...
OBJECTIVES: Bipolar disorder (BD) is a debilitating psychiatric illness affecting 2%-5% of the population. Although mania is the cardinal feature of BD, inattention and related cognitive dysfunction are observed across all stages. Since cognitive dysfunction confers poor functional outcome in patients, understanding the relevant neural mechanisms remains key to developing novel-targeted therapeutics. METHODS: The 5-choice continuous performance test (5C-CPT) is a mouse and fMRI-compatible human ...
9 CitationsSource
#1Awais Aftab (UCSD: University of California, San Diego)H-Index: 6
#2Colin A. Depp (UCSD: University of California, San Diego)H-Index: 59
Last. Lisa T. Eyler (UCSD: University of California, San Diego)H-Index: 47
view all 7 authors...
#1Laura Hein (UCSD: University of California, San Diego)
#2Annemiek Dols (VU: VU University Amsterdam)H-Index: 22
Last. Lisa T. Eyler (UCSD: University of California, San Diego)H-Index: 47
view all 3 authors...
Abstract Bipolar disorder (BD) is a serious mental illness affecting up to 1% of the elderly population. As the population ages and awareness surrounding BD increases, the prevalence of older-age bipolar disorder (OABD) is expected to rise. OABD is marked by high rates of functional impairment, physical comorbidity, cognitive deficits, and mortality, pointing to the need for an integrative biopsychosocial approach to care. Further research is needed to elucidate the etiology of early- versus lat...
#1Michael V. Lombardo (University of Cambridge)H-Index: 56
#2Lisa T. Eyler (UCSD: University of California, San Diego)H-Index: 47
Last. Karen Pierce (UCSD: University of California, San Diego)H-Index: 51
view all 8 authors...
Many parents of children with autism spectrum disorder (ASD) spot the first signs when their child is still a toddler, by noticing that their child is less interested than other toddlers in people and in social play. These early differences in behavior can have long-term implications for brain development. The brains of toddlers with little interest in social stimuli will receive less social input than those of other toddlers. This will make it even harder for the brain to develop the circuits r...
11 CitationsSource
#1Pauline Favre (Université Paris-Saclay)H-Index: 13
#2Melissa Pauling (French Institute of Health and Medical Research)H-Index: 3
Last. Josselin HouenouH-Index: 30
view all 59 authors...
Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies have reported heterogeneous results and it is not clear how the clinical heterogeneity is related to the observed differences. This study aimed to identify WM abnormalities that differentiate patients with BD from healthy controls (HC) in the largest DTI dataset of patients with BD to date, collected via the ENIGMA network....
34 CitationsSource
#1Martha Sajatovic (Case Western Reserve University)H-Index: 56
#2Lisa T. Eyler (UCSD: University of California, San Diego)H-Index: 47
Last. Annemiek Dols (PHRI: Public Health Research Institute)H-Index: 22
view all 14 authors...
Objective: There is a dearth of research about the aging process among individuals with bipolar disorder (BD). One potential strategy to overcome the challenge of interpreting findings from existing limited older-age bipolar disorder (OABD) research studies is to pool or integrate data, taking advantage of potential overlap or similarities in assessment methods and harmonizing or cross-walking measurements where different measurement tools are used to evaluate overlapping construct domains. This...
1 CitationsSource