Lisa T. Eyler
University of California, San Diego
PsychiatryInternal medicineDevelopmental psychologyPsychologyHeritabilityTwin studyNeuroscienceCognitionAutismBipolar disorderDepression (differential diagnoses)Functional magnetic resonance imagingMoodCerebral cortexWhite matterBrain mappingAudiologyNeuroimagingClinical psychologyMedicineSchizophreniaBiology
282Publications
47H-index
9,805Citations
Publications 194
Newest
#1Michael V. Lombardo (IIT: Istituto Italiano di Tecnologia)H-Index: 55
#2Lisa T. Eyler (UCSD: University of California, San Diego)H-Index: 47
Last. Eric Courchesne (UCSD: University of California, San Diego)H-Index: 116
view all 16 authors...
Cortical regionalization develops via genomic patterning along anterior-posterior (A-P) and dorsal-ventral (D-V) gradients. Here we find that normative A-P and D-V genomic patterning of cortical surface area (SA) and thickness (CT) present in typically developing and autistic toddlers with good early language outcome, is absent in autistic toddlers with poor early language outcome. Autistic toddlers with poor early language outcome are instead specifically characterized by secondary and independ...
1 CitationsSource
#1Sean R. McWhinney (Dal: Dalhousie University)H-Index: 6
#2Christoph Abé (KI: Karolinska Institutet)H-Index: 18
Last. Tomas Hajek (Dal: Dalhousie University)H-Index: 37
view all 84 authors...
Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and 1601 control individuals from 17 independent research sites within the ENIGMA-BD Working Group. We jointly modeled the effects of BD and BMI on subcortical volumes using mixed-effects modeling and tes...
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#1Federica Klaus (UCSD: University of California, San Diego)
#1Federica Klaus (UCSD: University of California, San Diego)H-Index: 5
Last. Tanya T. Nguyen (UCSD: University of California, San Diego)H-Index: 16
view all 5 authors...
ABSTRACT Background Peripheral levels of pro-inflammatory biomarkers have been shown to be altered in schizophrenia (SZ) and associated with cognitive impairments, but their relevance to specific cognitive domains remains unclear. Methods Plasma levels of cytokines, chemokines, and vascular biomarkers were quantified and compared between SZ and healthy comparison (HC) groups. Cognition was assessed using the Delis-Kaplan Executive Function System Trail Making (TM) and Color Word Interference (CW...
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#1Federica Klaus (UCSD: University of California, San Diego)H-Index: 5
Last. Lisa T. EylerH-Index: 47
view all 7 authors...
Introduction The coronavirus pandemic and resulting restrictions of social activity have the potential to differentially affect older adults. People over 65 years old are at increased vulnerability to COVID-19 compared to younger adults, which may increase anxiety and efforts to socially isolate. In addition, older adults may be uniquely affected by smaller social networks or less access to technological substitutes for social interactions. While a recent study on mental well-being among older a...
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#1Krishna C. Vadodaria (Salk Institute for Biological Studies)H-Index: 19
#2Ana P.D. Mendes (Salk Institute for Biological Studies)H-Index: 6
Last. Fred H. Gage (Salk Institute for Biological Studies)H-Index: 233
view all 14 authors...
Summary Bipolar disorder (BD) is characterized by cyclical mood shifts. Studies indicate that BD patients have a peripheral pro-inflammatory state and alterations in glial populations in the brain. We utilized an in vitro model to study inflammation-related phenotypes of astrocytes derived from induced pluripotent stem cells (iPSCs) generated from BD patients and healthy controls. BD astrocytes showed changes in transcriptome and induced a reduction in neuronal activity when co-cultured with neu...
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#1Osvaldo P. Almeida (UWA: University of Western Australia)H-Index: 90
#2Esther Jiménez (University of Barcelona)H-Index: 20
Last. Annemiek Dols (PHRI: Public Health Research Institute)H-Index: 19
view all 6 authors...
The implementation of public health measures designed to limit the spread of coronavirus disease 2019 (COVID-19) have been applied particularly stringently to people at high risk of complications, such as individuals older than 70 years and people with concurrent health morbidities like chronic respiratory or cardiovascular diseases. Older adults suffering from mental disorders are an especially high-risk group not only because of their age, but also because the prevalence of chronic somatic con...
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#1Ayana Jordan (Yale University)H-Index: 4
#2Ruth S. Shim (UC Davis: University of California, Davis)H-Index: 17
Last. Christina Mangurian (UCSF: University of California, San Francisco)H-Index: 18
view all 9 authors...
Author(s): Jordan, Ayana; Shim, Ruth S; Rodriguez, Carolyn I; Bath, Eraka; Alves-Bradford, Jean-Marie; Eyler, Lisa; Trinh, Nhi-Ha; Hansen, Helena; Mangurian, Christina | Abstract: Dr. A, a Black woman researcher and clinician-educator in the Department of Psychiatry at a prestigious academic institution, was appointed chair of the Diversity, Equity, and Inclusion (DEI) committee in 2017, in the context of public complaints and media coverage concerning sexism and racism. Following recent high-pr...
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#1Jeremy A. Elman (UCSD: University of California, San Diego)H-Index: 15
#2Olivia K. Puckett (UCSD: University of California, San Diego)H-Index: 1
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 71
view all 30 authors...
INTRODUCTION The locus coeruleus (LC) undergoes extensive neurodegeneration in early Alzheimer's disease (AD). The LC is implicated in regulating the sleep-wake cycle, modulating cognitive function, and AD progression. METHODS Participants were 481 men (ages 62 to 71.7) from the Vietnam Era Twin Study of Aging. LC structural integrity was indexed by neuromelanin-sensitive magnetic resonance imaging (MRI) contrast-to-noise ratio (LCCNR ). We examined LCCNR , cognition, amnestic mild cognitive imp...
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#1Ellen Lee (UCSD: University of California, San Diego)
#1Ellen Lee (UCSD: University of California, San Diego)H-Index: 1
Last. Lisa T. Eyler (UCSD: University of California, San Diego)H-Index: 47
view all 9 authors...
Premature mortality and increased physical comorbidity associated with bipolar disorder (BD) may be related to accelerated biological aging. Sleep disturbances and inflammation may be key mechanisms underlying accelerated aging in adults with BD. To our knowledge, these relationships have not been examined rigorously. This cross-sectional study included 50 adults with BD and 73 age- and sex-comparable non-psychiatric comparison (NC) subjects, age 26-65 years. Participants were assessed with wris...
1 CitationsSource
#1Hillary L Ditmars (BU: Boston University)H-Index: 1
#2Mark W. Logue (BU: Boston University)H-Index: 33
Last. Michael J. Lyons (BU: Boston University)H-Index: 86
view all 27 authors...
Background Clarifying the relationship between depression symptoms and cardiometabolic and related health could clarify risk factors and treatment targets. The objective of this study was to assess whether depression symptoms in midlife are associated with the subsequent onset of cardiometabolic health problems. Methods The study sample comprised 787 male twin veterans with polygenic risk score data who participated in the Harvard Twin Study of Substance Abuse ('baseline') and the longitudinal V...
1 CitationsSource