Charles L. Penninger
Zimmer Holdings
AlgorithmMathematical optimizationTopologyEngineeringBone cellFinite element methodBiomedical engineeringSurgeryResorptionNeuroscienceBone remodelingTopology (electrical circuits)Topology optimizationMaterials scienceRange (mathematics)Process (anatomy)CrashworthinessFemurOrthodonticsBone adaptationTotal knee arthroplastyFemoral componentMathematicsEngineering design processCellular automatonKarush–Kuhn–Tucker conditionsComputational modelStructural engineeringBone resorptionMedicineMechanical engineeringAnisotropyCell biology
15Publications
6H-index
201Citations
Publications 15
Newest
#1Yifei Dai (Zimmer Holdings)H-Index: 7
#2Charles L. Penninger (Zimmer Holdings)H-Index: 6
Last. J. Bischoff (Zimmer Holdings)
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INTRODUCTION During total knee arthroplasty (TKA), the pursuit of accurate alignment, proper bone cuts, and good soft tissue balancing sometimes can result in the overhang of the femoral component, especially in smaller-sized Asian knees. As size and shape of the distal femur are highly variable, component designs that offer increased shape and size offerings may be desirable to fit the distal femur. This study tested the hypothesis that increased shape and size offerings in TKA femoral designs ...
#1Yifei Dai (Zimmer Holdings)H-Index: 7
#2Giles R. ScuderiH-Index: 56
Last. Aaron G. Rosenberg (Rush University Medical Center)H-Index: 67
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Purpose Contemporary total knee arthroplasty femoral component designs offer various degrees of fit amongst the global population. The purpose of this study was to assess component fit of contemporary femoral component design families against multiple ethnicities.
Source
#2Andres TovarH-Index: 19
Last. John E. RenaudH-Index: 38
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Source
Aug 12, 2012 in DAC (Design Automation Conference)
#1Charles L. Penninger (Zimmer Holdings)H-Index: 6
#2Neal M. PatelH-Index: 13
Last. Andres Tovar (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 19
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Each year, bone metabolic diseases affect millions of people of all ages, genders, and races. Common diseases such as osteopenia and osteoporosis result from the disruption of the bone remodeling process and can place an individual at a serious fracture risk. Bone remodeling is the complex process by which old bone is replaced with new tissue. This process occurs continuously in the body and is carried out by bone cells that are regulated by numerous metabolic and mechanical factors. The remodel...
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#1Lianshui Guo (Beihang University)H-Index: 2
#2Andres Tovar (ND: University of Notre Dame)H-Index: 19
Last. John E. Renaud (ND: University of Notre Dame)H-Index: 38
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Structural design for crashworthiness is a challenging area of research due to large plastic deformations and complex interactions among diverse components of the vehicle. Previous research in this field primarily focused on energy absorbing structures that utilise a desired amount of material. These structures have been shown to absorb a large amount of the kinetic energy generated during the crash event; however, the large plastic strains experienced can lead to material failure and loss of st...
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#1Charles L. Penninger (ND: University of Notre Dame)H-Index: 6
#2Andres Tovar (ND: University of Notre Dame)H-Index: 19
Last. John E. Renaud (ND: University of Notre Dame)H-Index: 38
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One of the most intriguing aspects of bone is its ability to grow, repair damage, adapt to mechanical loads, and maintain mineral homeostasis [1]. It is generally accepted that bone adaptation occurs in response to the mechanical demands of our daily activities; moreover, strain and microdamage have been implicated as potential stimuli that regulate bone remodeling [2]. Computational models have been used to simulate remodeling in an attempt to better understand the metabolic activities which po...
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#1Charles L. Penninger (ND: University of Notre Dame)H-Index: 6
#2Andres Tovar (ND: University of Notre Dame)H-Index: 19
Last. John E. Renaud (ND: University of Notre Dame)H-Index: 38
view all 4 authors...
The bone remodeling process provides for various functions such as mineral homeostasis, damage repair, and adaptation to mechanical loading. At present, a clear link between the mechanical stimulation of bones and the biochemical response is not fully understood. Computational simulations can provide a means to test hypotheses and gain insight into processes that are difficult to examine experimentally. The objective of this work is to predict the effect of damage and strain as the stimulus for ...
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#1Charles L. Penninger (ND: University of Notre Dame)H-Index: 6
#2Layne T. Watson (VT: Virginia Tech)H-Index: 65
Last. John E. Renaud (ND: University of Notre Dame)H-Index: 38
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The hybrid cellular automaton (HCA) algorithm was inspired by the structural adaptation of bones to their ever changing mechanical environment. This methodology has been shown to be an effective topology synthesis tool. In previous work, it has been observed that the convergence of the HCA methodology is affected by parameters of the algorithm. As a result, questions have been raised regarding the conditions by which HCA converges to an optimal design. The objective of this investigation is to e...
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#1Neal M. Patel (ND: University of Notre Dame)H-Index: 13
#2Charles L. Penninger (ND: University of Notre Dame)H-Index: 6
Last. John E. Renaud (ND: University of Notre Dame)H-Index: 38
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Many practical structural designs require that the structure is easily manufactured. Design concepts synthesized using conventional topology optimization methods are typically not easily manufactured, in that multiple finishing processes are required to construct the component. A manufacturing technique that requires only minimal effort is extrusion. Extrusion is a manufacturing process used to create objects of a fixed cross-sectional profile. The result of using this process is lower costs for...
Source
#1Charles L. Penninger (ND: University of Notre Dame)H-Index: 6
#2Andres Tovar (ND: University of Notre Dame)H-Index: 19
Last. John E. Renaud (ND: University of Notre Dame)H-Index: 38
view all 4 authors...
The hybrid cellular automaton (HCA) method is a biologically inspired algorithm capable of topology synthesis that was developed to simulate the behavior of the bone functional adaptation process. In this algorithm, the design domain is divided into cells with some communication property among neighbors. Local evolutionary rules, obtained from classical control theory, iteratively establish the value of the design variables in order to minimize the local error between a field variable and a corre...
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